In vitro bioactivity of chitosan/poly (d,l-lactide-co-glycolide) composites

Martel-Estrada, Santos-Adriana; Martínez-Pérez, Carlos A.; Chacón-Nava, J.G.; García-Casillas, Perla E.; Olivas–Armendáriz, I.

doi:10.1016/j.matlet.2010.09.022

Cited by 25 publications

(11 citation statements)

References 15 publications

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“…Typical peaks of AST at 1651, 1552, 976 and 960 cm −1 were assigned to the C-O, C=C, and C-H stretching vibration peaks of the molecular skeleton, respectively. Compared with AST, the appearance of the vibration bands in H-ADC and J-ADC at 1086 and 1228 cm −1 for the symmetric and asymmetric stretching of the PO 2 group, as well as the N-H bending vibration of the chitosan band at 1524 cm −1 well illustrated that H-ADC and J-ADC were constructed based on the non-covalent interactions among chitosan, DNA and AST [34]. Moreover, ADC nanoparticles showed considerably decreased peak intensities at 1651, 976 and 960 cm −1 relative to AST, accompanied with the disappearance of the C=C stretching vibration peak at 1552 cm −1 , further indicating the embedment of AST in the inner-core of the DNA-chitosan nanocarriers due to the polar interactions between the host and guest molecules [35].…”

Section: Preparation and Characterization Of Astaxanthin Aggregate-emmentioning

confidence: 93%

The Astaxanthin Aggregation Pattern Greatly Influences Its Antioxidant Activity: A Comparative Study in Caco-2 Cells

Dai

Yang

et al. 2020

Antioxidants

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Astaxanthin is an excellent antioxidant that can form unstable aggregates in biological or artificial systems. The changes of astaxanthin properties caused by molecular aggregation have gained much attention recently. Here, water-dispersible astaxanthin H- and J-aggregates were fabricated and stabilized by a natural DNA/chitosan nanocomplex (respectively noted as H-ADC and J-ADC), as evidenced by ultraviolet and visible spectrophotometry, Fourier transform infrared spectroscopy, and Raman spectroscopy. Compared with J-ADC, H-ADC with equivalent astaxanthin loading capacity and encapsulation efficiency showed smaller particle size and similar zeta potential. To explore the antioxidant differences between astaxanthin H- and J-aggregates, H-ADC and J-ADC were subjected to H2O2-pretreated Caco-2 cells. Compared with astaxanthin monomers and J-aggregates, H-aggregates showed a better cytoprotective effect by promoting scavenging of intracellular reactive oxygen species. Furthermore, in vitro 1,1-diphenyl-2-picrylhydrazyl and hydroxyl free radical scavenging studies confirmed a higher efficiency of H-aggregates than J-aggregates or astaxanthin monomers. These findings give inspiration to the precise design of carotenoid aggregates for efficient utilization.

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Section: Preparation and Characterization Of Astaxanthin Aggregate-emmentioning

confidence: 93%

The Astaxanthin Aggregation Pattern Greatly Influences Its Antioxidant Activity: A Comparative Study in Caco-2 Cells

Dai

Yang

et al. 2020

Antioxidants

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“…[44] Sr-containing nanosized bioactive glass particles PO 4 ] and HA dispersed solution containing Ca and P ions as electrolyte. The bonding strength between the TiO 2 layer and substrate was calculated by a universal testing machine.…”

Section: Materials or Coatings Methodsmentioning

confidence: 99%

Review of the biocompatibility of micro-arc oxidation coated titanium alloys

et al. 2015

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“…However, the acid degradation products and poor cells affinities limit the scope in tissue engineering applications 67 . In contrast, chitosan exhibits good cytocompatibility 68 and antimicrobial property but low mechanical strength as a biodegradable natural basic polysaccharide, which has been commonly used to complex with polylacitide for improving the cytocompatibility and neutralizing the acid degradation products of polylactides in biomedical application 69 , 70 . In previous work, chitosan nanofibers (CSNFs) 71 mimicking the ECM collagen structure with a diameter range of 50–500 nm have been first engineered via a new developed solid–liquid TIPS, 72 which provides the possibility to fabricate a new biomimetic composite nanofibrous scaffold taking advantage of the good mechanical property of PLLA and the excellent cytocompatibility of chitosan by introducing CSNFs network into the macropores of nanofibrous PLLA scaffold (NF‐PLLA) via a dual TIPS technique.…”

Section: Main Types Of Nano‐scaffolds Materials For Bone Tissue Enginmentioning

confidence: 99%

Nanostructured scaffolds for bone tissue engineering

Wang

Fan

et al. 2013

J Biomedical Materials Res

292

218

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It has been demonstrated that nanostructured materials, compared with conventional materials, may promote greater amounts of specific protein interactions, thereby more efficiently stimulating new bone formation. It has also been indicated that, when features or ingredients of scaffolds are nanoscaled, a variety of interactions can be stimulated at the cellular level. Some of those interactions induce favorable cellular functions while others may leads to toxicity. This review presents the mechanism of interactions between nanoscaled materials and cells and focuses on the current research status of nanostructured scaffolds for bone tissue engineering. Firstly, the main requirements for bone tissue engineering scaffolds were discussed. Then, the mechanism by which nanoscaled materials promote new bone formation was explained, following which the current research status of main types of nanostructured scaffolds for bone tissue engineering was reviewed and discussed.

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In vitro bioactivity of chitosan/poly (d,l-lactide-co-glycolide) composites

Cited by 25 publications

References 15 publications

The Astaxanthin Aggregation Pattern Greatly Influences Its Antioxidant Activity: A Comparative Study in Caco-2 Cells

The Astaxanthin Aggregation Pattern Greatly Influences Its Antioxidant Activity: A Comparative Study in Caco-2 Cells

Review of the biocompatibility of micro-arc oxidation coated titanium alloys

Nanostructured scaffolds for bone tissue engineering

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