In vitro bioactivity of a biocomposite fabricated from HA and Ti powders by powder metallurgy method

Ning, Congqin; Zhou, Yu

doi:10.1016/s0142-9612(01)00419-7

Cited by 216 publications

(139 citation statements)

References 35 publications

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“…Such effect has been detected by energy-dispersive X-ray spectroscopy in HA/TiO 2 biocomposite particles with partial formation of calcium titanates; this process was found to be favorable to enhancing the cohesive strength of particles in the composite coating [817]. A similar high-temperature interaction between HA and zirconia [743,768], as well as between HA and Ti [554,840,[842][843][844], was also detected. Besides, partial decomposition of HA and formation of different calcium aluminates were detected in HA/Al 2 O 3 biocomposites after sintering at 1200-1300°C [795,801,802].…”

Section: Biosensorsmentioning

confidence: 89%

“…Besides, calcium orthophosphates/Ti biocomposites might be prepared by powder metallurgy processing [842][843][844]. At high temperatures, the presence of Ti metal phase was found to promote dehydration and decomposition of HA into b-TCP and TTCP [840,842] or partial formation of b-TCP and calcium titanate instead of HA [554,843,844]. Comparing with pure HA bioceramics manufactured under the same conditions, the HA/Ti biocomposites possessed a higher fracture toughness, bending strength, work of fracture, porosity, and lower elastic modulus, which is more suitable for biomedical applications.…”

Section: Biocomposites With Glasses Inorganic Materials and Metalsmentioning

confidence: 99%

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Calcium orthophosphate-based biocomposites and hybrid biomaterials

Dorozhkin¹

2009

J Mater Sci

283

146

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Section: Biosensorsmentioning

confidence: 89%

Section: Biocomposites With Glasses Inorganic Materials and Metalsmentioning

confidence: 99%

Calcium orthophosphate-based biocomposites and hybrid biomaterials

Dorozhkin¹

2009

J Mater Sci

283

146

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“…This combination can be achieved by a powder metallurgy technique using appropriate mixtures of titanium and calcium phosphate powders. Many titanium composites containing hidroxiapatite, calcium phosphates or a mixture of varying contents of calcium and phosphorous compounds were synthesized through powder metallurgy under different processing conditions [9][10][11][12][13][14][15][16][17][18][19] . Although reporting densification and microstructure of biomaterials fabricated with various parameters, these investigations still cover a limited number of conditions such as raw materials, processing methods, particles size and their chemical and morphologic characteristics, which can lead to different results.…”

Section: Introductionmentioning

confidence: 99%

Microstructure development on sintered Ti/HA biocomposites produced by powder metallurgy

et al. 2011

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Titanium-based composites with in-situ calcium and phosphor phases were prepared by powder metallurgy processing with titanium and hydroxyapatite (HA) powders. The mixtures were performed in a friction mill with alcohol for 5 hours, dried in a rotating evaporator, pressed at 600 MPa and sintered at 1200 °C for 2 hours in argon atmosphere. Crystal phases of the as-fabricated composite are found to be, α-Ti, CaTiO 3 , Ca 3 (PO 4 ) 2 and Ti x P y phase(s). The analyses revealed that titanium particles were covered with a compact layer of Ti x P y and CaTiO 3 phases, which resulted from the decomposition of HA into CaTiO 3 and β-Ca 3 (PO 4 ) 2 at approximately 1025 °C. Then the reactions were followed by the decomposition of β-Ca 3 (PO 4 ) 2 , resulting in the growth of CaTiO 3 layer and in the nucleation and growth of Ti x P y phase(s).

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“…[36][37][38] The apatite FE-SEM morphology of the investigated samples after immersion in the simulated physiological solution for seven days is exhibited in Fig. 6.…”

Section: Resultsmentioning

confidence: 99%

Electrochemical Behavior in Simulated Physiological Solution of Ti-Nb-Zr-Calcium Pyrophosphate Composite with Enhanced Bioactivity by Spark Plasma Sintering

Zhang

Zhao

Tan

et al. 2018

J. Electrochem. Soc.

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The potential biomedical application near β-type Ti-35Nb-7Zr alloy with different CPP ceramic additions were evaluated in vitro using electrochemical method and osteoblasts co-cultured. A small amount addition of calcium pyrophosphate (CPP) ceramic induced the formation of oxide film on the surface of the composites that can withstand passive layer breakdown and the onset of localized forms of corrosion. But localized breakdown of the oxide layer occurred on composites as the CPP exceeded 20 wt%. Ti-35Nb-7Zr-10CPP exhibits a wide passive range in the polarization curve and gets a higher potential for inducing growth of bone-like apatite and proliferation of osteoblasts on its surface compared to that of the Ti-35Nb-7Zr, CP Ti and Ti6Al4V (TC4) alloys. The favorable cell viability and growth inside the pores of the composites arise from the rough micro-porous surface and the release of bioactive metal-ceramic phase ions into the physiological environment. Novel near β-type Ti-Nb-based alloys have attracted considerable attention for human bone implants due to their good mechanical properties, high corrosion resistance and low toxicity.1-3 Based on the Ti-Nb binary system, several near β-type Ti alloy containing nontoxic elements (Ta, Zr, Mo and Sn) have recently been developed for biomaterials. [4][5][6][7] Among them, Zr received renewed attention for surgical implants because it shows acceptable mechanical strength, satisfactory biocompatibility and corrosion resistance. In addition, Zr is a neutral element when dissolved in Ti and it can improve the strength. Zr-containing Ti alloys have been developed for commercial biomaterials. [8][9][10][11][12] It is reported that the elastic modulus of a near β-type Ti-Nb-Zr alloy at room temperature are about 40-55 GPa if the alloy composition and heat-treatment conditions are optimized. 10,13,14 This value is close to the elastic modulus of human bones (10-30 GPa) and it is conducive to reducing the stress shielding between natural bones and implants.15 Thus, β-type Ti-Nb-Zr alloys are considered to be one of the most promising alloys for biomedical applications. However, the osseointegration property of Ti-Nb-Zr alloys, which is necessary to promote bone tissue compatibility, is poorer than bio-ceramic materials because they are bio-inert. [15][16][17] Calcium pyrophosphate (Ca 2 P 2 O 7 , CPP) 18,19 is a bioactive ceramic material that has recently attracted wide attention in clinical orthopedic and bone repaired implants due to its similar chemical and crystallographic structure to natural bone apatite mineral. Maeda et al. 20 fabricated a CPP-Nb glass-ceramic, which mainly consisted of α-Ca 2 P 2 O 7 , β-Ca 2 P 2 O 7 and Nb 2 O 5 phases. In vitro tests revealed that CPP ceramic could significantly induce the formation and growth of bone-like apatite on the surface of the material. According to a research work from Lin et al., 21 a porous CPP-5 wt% Na 4 P 2 O 7 •10H 2 O ceramic was fabricated by powder sintering, and was implanted into New Zealand Rabbits. The vivo ...

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In vitro bioactivity of a biocomposite fabricated from HA and Ti powders by powder metallurgy method

Cited by 216 publications

References 35 publications

Calcium orthophosphate-based biocomposites and hybrid biomaterials

Calcium orthophosphate-based biocomposites and hybrid biomaterials

Microstructure development on sintered Ti/HA biocomposites produced by powder metallurgy

Electrochemical Behavior in Simulated Physiological Solution of Ti-Nb-Zr-Calcium Pyrophosphate Composite with Enhanced Bioactivity by Spark Plasma Sintering

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