In vitro bioactivity and biocompatibility of calcium phosphate cements using Hydroxy-propyl-methyl-Cellulose (HPMC)

Jyoti, Md. Anirban; Thai, Van Viet; Min, Young Ki; Lee, Byong‐Taek; Song, Ho‐Yeon

doi:10.1016/j.apsusc.2010.08.091

Cited by 24 publications

(19 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Specifically, polysaccharides [97,108,[335][336][337][338], gelatin [278,[339][340][341][342][343][344][345] and polyacrylic acid [346][347][348] are of an interest due to their biocompatibility and good rheological properties. Only small amounts (a few weight %) are needed to dramatically increase the viscosity of the cement pastes.…”

Section: Properties Improvingmentioning

confidence: 99%

“…In order to maintain a good cohesion and reduce filter pressing, calcium orthophosphate cements need to be more viscous (hence, less injectable) [197,198]. For example, calcium orthophosphate cements might be modified by addition of polysaccharides [97,108,[335][336][337][338] and/or gelatin [278,[339][340][341][342][343][344].…”

Section: Brief Conclusion On the Medical Applicationsmentioning

confidence: 99%

See 1 more Smart Citation

Self-Setting Calcium Orthophosphate Formulations: Cements, Concretes, Pastes and Putties

Dorozhkin¹

2012

IJMC

View full text Add to dashboard Cite

In early 1980s, researchers discovered self-setting calcium orthophosphate cements, which are a bioactive and biodegradable grafting material in the form of a powder and a liquid. Both phases after mixing form a viscous paste that after being implanted sets and hardens within the body as either a non-stoichiometric calcium deficient hydroxyapatite (CDHA) or brushite, sometimes blended with un-reacted particles and other phases. As both CDHA and brushite are remarkably biocompartible and bioresorbable (therefore, in vivo they can be replaced with a newly forming bone), self-setting calcium orthophosphate cements represent a good correction technique of non-weight-bearing bone fractures or defects and appear to be very promising materials for bone grafting applications. Besides, these cements possess an excellent osteoconductivity, molding capabilities, and easy manipulation. Nearly perfect adaptation to the tissue surfaces in bone defects and a gradual bioresorption followed by new bone formation are additional distinctive advantages of calcium orthophosphate cements. Besides, reinforced formulations are available; those are described as calcium orthophosphate concretes. Furthermore, formulations with high viscosity, such as pastes and putties are also known. The discovery of self-setting formulations has opened up a new era in the medical application of calcium orthophosphates; several commercial compositions have already been introduced as a result. Many more formulations are in experimental stages. In this review, an insight into the self-setting calcium orthophosphate formulations, as excellent biomaterials suitable for both dental and bone grafting applications, has been provided.

show abstract

Section: Properties Improvingmentioning

confidence: 99%

Section: Brief Conclusion On the Medical Applicationsmentioning

confidence: 99%

Self-Setting Calcium Orthophosphate Formulations: Cements, Concretes, Pastes and Putties

Dorozhkin¹

2012

IJMC

View full text Add to dashboard Cite

show abstract

“…[5][6][7] But they have poor mechanical properties like low fracture toughness, which creates space to find alternative bioceramics. 8,9 Thus, wollastonite is considered an ideal candidate for artificial bone implants in hard tissue regeneration and bone tissue engineering 10,11 and is also widely used in drug delivery applications. 12 The formation rate of hydroxyapatite on the surface of the wollastonite proved to be faster than that of any other biocompatible glasses, glass ceramics, and calcium phosphates due to the presence of silicate group which actively takes part in the metabolic processes during bone formation.…”

Section: Introductionmentioning

confidence: 99%

Influence of needle-like morphology on the bioactivity of nanocrystalline wollastonite – an in vitro study

Lakshmi¹,

Swamiappan²

2015

IJN

View full text Add to dashboard Cite

In the past 2 decades, wollastonite has been studied thoroughly for its application as a bone implant material due to its biocompatibility, high mechanical strength, and excellent bioactivity when compared to calcium phosphates bioceramics. Wollastonite was prepared through the low-temperature sol-gel combustion method using urea as the fuel, nitrate ions and nitric acid as the oxidizer. Calcium nitrate and tetraethyl orthosilicate were taken as the source of calcium and silica. The synthesized wollastonite were characterized by Fourier transform infrared spectroscopy for the identification of characteristic functional group and powder X-ray diffraction for the phase identification. Employing urea as a fuel resulted in needle-like morphology of the particles, which was confirmed by scanning electron microscopy and transmission electron microscopy. It was observed that the needle-like morphology enhances the mechanical properties such as elasticity and compressive strength and also increases the surface area of the material, which could help in a rapid deposition of hydroxyapatite layer. These properties of wollastonite warrant its application as a new artificial bone material in the field of hard tissue engineering.

show abstract

“…Specifically, polysaccharides [120,132,[380][381][382][383], gelatin [317,[384][385][386][387][388][389][390] and polyacrylic acid [391][392][393] are of an interest due to their biocompatibility and good rheological properties. Only small amounts (a few weight %) are needed to dramatically increase the viscosity of the pastes.…”

Section: Properties Improvingmentioning

confidence: 99%

“…In order to maintain a good cohesion and reduce filter pressing, the calcium orthophosphate formulations need to be more viscous (hence, less injectable) [4,5]. For example, they might be modified by addition of polysaccharides [120,132,[380][381][382][383] and/or gelatin [317,[384][385][386][387][388][389].…”

Section: Brief Conclusion On the Biomedical Applicationsmentioning

confidence: 99%

Self-Setting Calcium Orthophosphate Formulations

Dorozhkin¹

2012

Calcium Orthophosphates

View full text Add to dashboard Cite

Abstract:In early 1980s, researchers discovered self-setting calcium orthophosphate cements, which are bioactive and biodegradable grafting bioceramics in the form of a powder and a liquid. After mixing, both phases form pastes, which set and harden forming either a non-stoichiometric calcium deficient hydroxyapatite or brushite. Since both of them are remarkably biocompartible, bioresorbable and osteoconductive, self-setting calcium orthophosphate formulations appear to be promising bioceramics for bone grafting. Furthermore, such formulations possess excellent molding capabilities, easy manipulation and nearly perfect adaptation to the complex shapes of bone defects, followed by gradual bioresorption and new bone formation. In addition, reinforced formulations have been introduced, which might be described as calcium orthophosphate concretes. The discovery of self-setting properties opened up a new era in the medical application of calcium orthophosphates and many commercial trademarks have been introduced as a result. Currently such formulations are widely used as synthetic bone grafts, with several advantages, such as pourability and injectability. Moreover, their low-temperature setting reactions and intrinsic porosity allow loading by drugs, biomolecules and even cells for tissue engineering purposes. In this review, an insight into the self-setting calcium orthophosphate formulations, as excellent bioceramics suitable for both dental and bone grafting applications, has been provided.

show abstract

In vitro bioactivity and biocompatibility of calcium phosphate cements using Hydroxy-propyl-methyl-Cellulose (HPMC)

Cited by 24 publications

References 30 publications

Self-Setting Calcium Orthophosphate Formulations: Cements, Concretes, Pastes and Putties

Self-Setting Calcium Orthophosphate Formulations: Cements, Concretes, Pastes and Putties

Influence of needle-like morphology on the bioactivity of nanocrystalline wollastonite – an in vitro study

Self-Setting Calcium Orthophosphate Formulations

Contact Info

Product

Resources

About

In vitro bioactivity and biocompatibility of calcium phosphate cements using Hydroxy-propyl-methyl-Cellulose (HPMC)

Cited by 24 publications

References 30 publications

Self-Setting Calcium Orthophosphate Formulations: Cements, Concretes, Pastes and Putties

Self-Setting Calcium Orthophosphate Formulations: Cements, Concretes, Pastes and Putties

Influence of needle-like morphology on the bioactivity of nanocrystalline wollastonite &ndash; an in vitro study

Self-Setting Calcium Orthophosphate Formulations

Contact Info

Product

Resources

About

Influence of needle-like morphology on the bioactivity of nanocrystalline wollastonite – an in vitro study