In Vitro Bile Acid Binding Capacity of Wheat Bran with Different Particle Sizes

Li, Chunyan; Mense, Andrew L.; Brewer, Lauren R.; Lau, Chuan; Shi, Yong‐Cheng

doi:10.1094/cchem-08-16-0211-r

Cited by 8 publications

(10 citation statements)

References 33 publications

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“…For both protein sources, three diets were formulated with increasing inclusion level of an NSP‐rich ingredient mixture (Table ). Some NSP can sequester bile acids (Li, Mense, Brewer, Lau, & Shi, ), and increasing the dietary NSP level aimed at enhancing faecal bile acid loss. Enhanced faecal bile acid loss was hypothesized to reduce the amount of bile acids available for micelle formation, resulting in a reduction of fat ADC.…”

Section: Discussionmentioning

confidence: 99%

The effect of dietary protein source (fishmeal vs. plant protein) and non‐starch polysaccharide level on fat digestibility and faecal bile acid loss in rainbow trout (Oncorhynchus mykiss)

et al. 2019

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This study investigated in rainbow trout (Oncorhynchus mykiss) if diet composition and feeding level affect faecal bile acid loss, and whether this reflects on the apparent digestibility coefficient (ADC) of fat. Six diets were formulated with either fishmeal or plant protein as main protein source. This created a contrast in the supply of bile acids, the bile acid precursor cholesterol, taurine and the taurine precursors (methionine + cysteine) involved in bile acid conjugation. For both protein sources, three diets were formulated with increasing inclusion of a non-starch polysaccharide (NSP)-rich ingredient mixture (0.0, 82.0 and 164.2 g/kg diet). This aimed at enhancing faecal bile acid loss. Fish were fed both restrictively (1.2% BW/day) and to satiation.A similar fat ADC was found when substituting fishmeal with a plant protein mixture, suggesting that the lower content of bile acids, cholesterol, taurine, methionine and cysteine in the plant-based diets did not limit fat digestion. Faecal bile acid loss increased alongside dietary NSP level, however, only during satiation feeding and most strongly for fish fed the fishmeal-based diets. Enhanced faecal bile acid loss was not caused by NSP-bile acid binding/entrapment, but by an increase in faeces production. During satiation feeding, fat ADC negatively correlated with faecal bile acid loss.From this it is concluded that bile acid availability/synthesis can become limiting for fat digestion in rainbow trout under conditions that enhance faecal bile acid loss (i.e. dietary NSP level and feeding level). K E Y W O R D Sbile acids, cholesterol, fat digestibility, non-starch polysaccharides, Oncorhynchus mykiss, taurine | 1171 STAESSEN ET Al.

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Section: Discussionmentioning

confidence: 99%

The effect of dietary protein source (fishmeal vs. plant protein) and non‐starch polysaccharide level on fat digestibility and faecal bile acid loss in rainbow trout (Oncorhynchus mykiss)

et al. 2019

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“…A case study approach was used to ascertain the consequences of this uniqueness. Searches in individual and combinations of databases were used to determine the number of peer‐reviewed articles published on the “in vitro bile acid binding properties of dietary fibers.” This topic is of general interest with regard to the use of dietary fibers as functional food components; bile acid binding is a putative mechanism by which dietary fiber consumption effects cholesterol metabolism (Gunness & Gidley, ; Kahlon, ; Li, Mense, Brewer, Lau, & Shi, ; Liu et al., ). The topic is also appropriate for this study because it is sufficiently refined so as to yield manageable numbers of publications in database searches.…”

Section: Resultsmentioning

confidence: 99%

Information Retrieval in Food Science Research: A Bibliographic Database Analysis

Urhan

Rempel

Meunier-Goddik

et al. 2018

Journal of Food Science

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The aim of the present research was to ascertain the importance of electronic bibliographic database selection and multiple database usage during the information retrieval phase of research in the food sciences. Six commonly recommended databases were compared with respect to overall journal coverage and journal overlap. Databases were also evaluated with respect to coverage of food science-based journals and the extent of article coverage therein. A case study approach, focused on bile acid/dietary fiber interactions, was used to illustrate the ramifications of database selection/usage when dealing with specific research topics. Databases differed with respect to the breadth of disciplines covered, the total number of journals indexed, the number of food science discipline-specific journals indexed, and the number of articles included per indexed journal. All of the databases contained citations that were unique to the given database. The data resulting from the case study provide an example of the extent to which relevant information may be missed if pertinent databases are not mined. In the present case, over half of the articles retrieved on the focus research topic were unique to a single database. The combined data from this study point to the importance of thoughtful database selection and multiple database usage when comprehensively assessing knowledge in the food sciences.Practical Application: This paper provides insights into article database usage for food science-relevant information retrieval. Online information retrieval is an efficient way to assess current knowledge in any of the food science disciplines. Acquired knowledge in turn is the underpinning of effective problem solving; whether it be private sectoror academic/government-based research.

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“…The DFs can be further categorized on the basis of their solubilities in water, like soluble DF (SDF) and insoluble DF (IDF). This is a key component in understanding their mechanism for hindering enterohepatic circulation; soluble DFs increase the viscosity of chyme by binding to water molecules, leading to a lower diffusion rate of bile acids, whereas insoluble DFs are often associated with adsorbing bile acids. − The use of such DFs as potential BASs and the lowering of cholesterol has been studied since the 1980s. We will discuss and highlight several examples of the BA capabilities of several DFs conducted in vivo as listed in Table .…”

Section: Dietary Fibers and Lignin Complexes As Bile Acid Sequestrantsmentioning

confidence: 99%

Bile Acid Sequestrants for Hypercholesterolemia Treatment Using Sustainable Biopolymers: Recent Advances and Future Perspectives

et al. 2022

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Bile acids, the endogenous steroid nucleus containing signaling molecules, are responsible for the regulation of multiple metabolic processes, including lipoprotein and glucose metabolism to maintain homeostasis. Within our body, they are directly produced from their immediate precursors, cholesterol C (low-density lipoprotein C, LDL-C), through the enzymatic catabolic process mediated by 7-α-hydroxylase (CYP7A1). Bile acid sequestrants (BASs) or amphiphilic resins that are nonabsorbable to the human body (being complex high molecular weight polymers/electrolytes) are one of the classes of drugs used to treat hypercholesterolemia (a high plasma cholesterol level) or dyslipidemia (lipid abnormalities in the body); thus, they have been used clinically for more than 50 years with strong safety profiles as demonstrated by the Lipid Research Council–Cardiovascular Primary Prevention Trial (LRC–CPPT). They reduce plasma LDL-C and can slightly increase high-density lipoprotein C (HDL-C) levels, whereas many of the recent clinical studies have demonstrated that they can reduce glucose levels in patients with type 2 diabetes mellitus (T2DM). However, due to higher daily dosage requirements, lower efficacy in LDL-C reduction, and concomitant drug malabsorption, research to develop an “ideal” BAS from sustainable or natural sources with better LDL-C lowering efficacy and glucose regulations and lower side effects is being pursued. This Review discusses some recent developments and their corresponding efficacies as bile removal or LDL-C reduction of natural biopolymer (polysaccharide)-based compounds.

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In Vitro Bile Acid Binding Capacity of Wheat Bran with Different Particle Sizes

Abstract: Cereal Chem. 94(4):654-658

Cited by 8 publications

References 33 publications

The effect of dietary protein source (fishmeal vs. plant protein) and non‐starch polysaccharide level on fat digestibility and faecal bile acid loss in rainbow trout (Oncorhynchus mykiss)

The effect of dietary protein source (fishmeal vs. plant protein) and non‐starch polysaccharide level on fat digestibility and faecal bile acid loss in rainbow trout (Oncorhynchus mykiss)

Information Retrieval in Food Science Research: A Bibliographic Database Analysis

Bile Acid Sequestrants for Hypercholesterolemia Treatment Using Sustainable Biopolymers: Recent Advances and Future Perspectives

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