In vitro behavior of silk fibroin-based composite resorbable bone fixation devices

Heimbach, Bryant; Yu, Le; Wei, Mei

doi:10.1016/j.mtla.2020.100587

Cited by 5 publications

(4 citation statements)

References 40 publications

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“…As one can picture the strength of spider webs seen in daily life, silk fibroin is a natural protein with outstanding mechanical properties. As a result, it has been popularly used in load-bearing scenarios such as bioresorbable bone fixation devices [148,149], load-bearing scaffolds for dermal tissue regeneration [150] and bone regeneration [151]. In addition, due to its excellent biocompatibility, superb flexural strength, and good elasticity, numerous of SF-based NGCs have been developed and encouraging outcomes have been achieved [54,[152][153][154].…”

Section: Proteinsmentioning

confidence: 99%

Scaffold design considerations for peripheral nerve regeneration

Yu,

Bennett,

Lin

et al. 2024

J. Neural Eng.

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Peripheral nerve injury (PNI) represents a serious clinical and public health problem due to its high incurrence and poor spontaneous recovery. Compared to autograft, which is still the best current practice for long-gap peripheral nerve defects in clinics, the use of polymer-based biodegradable nerve guidance conduits (NGCs) has been gaining momentum as an alternative to guide the repair of severe PNI without the need of secondary surgery and donor nerve tissue. However, simple hollow cylindrical tubes can barely outperform autograft in terms of the regenerative efficiency especially in critical sized PNI. With the rapid development of tissue engineering technology and materials science, various functionalized NGCs have emerged to enhance nerve regeneration over the past decades. From the aspect of scaffold design considerations, with a specific focus on biodegradable polymers, this review aims to summarize the recent advances in NGCs by addressing the onerous demands of biomaterial selections, structural designs, and manufacturing techniques that contributes to the biocompatibility, degradation rate, mechanical properties, drug encapsulation and release efficiency, immunomodulation, angiogenesis, and the overall nerve regeneration potential of NGCs. In addition, several commercially available NGCs along with their regulation pathways and clinical applications are compared and discussed. Lastly, we discuss the current challenges and future directions attempting to provide inspiration for the future design of ideal NGCs that can completely cure long-gap peripheral nerve defects.

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Section: Proteinsmentioning

confidence: 99%

Scaffold design considerations for peripheral nerve regeneration

Yu,

Bennett,

Lin

et al. 2024

J. Neural Eng.

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“…Silk fibroin (SF) is a common natural polymer with excellent mechanical properties. [24][25][26][27] Moreover, better mechanical characteristics can be achieved by editing SF with spider silk genes. [28][29][30][31] In addition, SF can hardly cause immune rejection due to its outstanding biocompatibility.…”

Section: Introductionmentioning

confidence: 99%

Personalized and Programmable Microneedle Dressing for Promoting Wound Healing

Wang

Guo

et al. 2021

Adv Healthcare Materials

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Microneedle (MN) dressings, with the ability of transdermal drug delivery, have played an essential role in the field of wound healing. However, patients may still feel uncomfortable when sensitive unhealing wounds are pieced by strong needles. Here, inspired by the structure of mosquito mouthparts, which possess a fixation part and a liquid-transferring part, we present a novel MN wound dressing with superfine needle tips, personalized pattern design, programmable needle length, and multiple mechanical strengths for intelligent and painless drug delivery. By simply stretching the silicone rubber (Ecoflex) molds before engraving, superfine MNs can be formed in the restored molds. Meanwhile, by utilizing intelligent image recognition, precise treatment for irregular wounds is achieved. Notably, combined with temperature-responsive N-isopropylacrylamide (NIPAM) hydrogel and inverse opal (IO) photonic crystals (PCs), a controllable drug release system has been achieved on MN dressings. Moreover, the performance of the MN dressing in facilitating wound recovery has been demonstrated by full-thickness skin wounds of a mouse model. These results indicate that novel personalized and programmable MN wound dressings are of considerable value in the field of wound management.

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“…Compared to other natural polymers, fibroin has better mechanical properties. 23 Fibroin with excellent toughness and ductility is often used as a tissue engineering and biomedical material. 24,25 At the same time, silk fibroin has good biocompatibility 26 and good tolerance and biodegradability in vivo.…”

Section: Introductionmentioning

confidence: 99%

“…Silk protein fibroin is a common natural polymer. Compared to other natural polymers, fibroin has better mechanical properties . Fibroin with excellent toughness and ductility is often used as a tissue engineering and biomedical material. , At the same time, silk fibroin has good biocompatibility and good tolerance and biodegradability in vivo . , This material hardly ever causes immune rejection. , The versatility of silk fibroin makes it widely used for drug delivery .…”

Section: Introductionmentioning

confidence: 99%

Combined Silk Fibroin Microneedles for Insulin Delivery

Zhu

Liu

Jiang

et al. 2020

ACS Biomater. Sci. Eng.

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To reduce the pain caused by subcutaneous injections, microneedle patches as the new transdermal drug delivery method are gaining increased attention. In this study, we fabricated a composite insulin-loaded microneedle patch. Silk fibroin, a natural polymer material, was used as the raw material. The tip of the microneedle had good dissolving property and was able to dissolve rapidly to promote the release of insulin. The pedestal had the property of swelling without dissolving and was carrying insulin as a drug store. The insulin carried by the pedestal could release continuously through the micropore channels created by the microneedles. This kind of microneedle could achieve a sustained release effect. It was observed that the insulin had good storage stability in this kind of microneedle, and it maintained more than 90% of its biological activity after 30 days. The results of transdermal delivery to diabetic rats showed that the microneedle patches displayed an apparent hypoglycemic effect and indicated a sustained release effect. These drug-loaded silk microneedle patches may act as potential delivery systems for the treatment of diabetes.

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In vitro behavior of silk fibroin-based composite resorbable bone fixation devices

Cited by 5 publications

References 40 publications

Scaffold design considerations for peripheral nerve regeneration

Scaffold design considerations for peripheral nerve regeneration

Personalized and Programmable Microneedle Dressing for Promoting Wound Healing

Combined Silk Fibroin Microneedles for Insulin Delivery

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