In vitro bactericidal activity of antimicrobial agents against enterohaemorrhagic Escherichia coli

Abstract

Norfloxacin had marked bactericidal effects on enterohaemorrhagic E. coli. This information could be of value in planning randomized clinical trials of antimicrobial agents as treatment for enterohaemorrhagic E. coli infection.

Characterization of antimicrobial resistance patterns and class 1 integrons in Escherichia coli O26 isolated from humans and animals

“…Initially, fosfomycin resistance was not reported in STEC O26 strains; however; in more recent studies, a high resistance to fosfomycin was found in E. coli O26 clinical isolates [6,10]. Approximately 23% of E. coli O26 isolates in this study were resistant to fosfomycin.…”

“…The most common resistances observed were to aztreonam, ampicillin, tetracycline and streptomycin. Previous studies [4,6,[8][9][10][11]23] demonstrated multiple antimicrobial resistances in different STEC serotypes from a variety of sources. Humans and animals may acquire drugresistant E. coli O26 strains through many routes, such as selection pressure from antimicrobial therapy, use of drug supplements in food or contamination from workers.…”

“…The role of antimicrobial agents in the management of enterohaemorrhagic E. coli infection remains debatable [6]. However, antimicrobial administration has been used as one of the major treatments for eradication of STEC from the gastrointestinal tract of humans and animals and their use has been associated with development of antimicrobial resistance [7].…”

“…The impact of antimicrobial-resistant bacteria on treatment options and outcomes in human medicine has become both a national and international concern. Recently, antimicrobial susceptibility profiles of E. coli isolates of different serotypes from non-hospital sources, especially animals [3,4,8,9] and 0924-8579/$ -see front matter doi:10.1016/j.ijantimicag.2006.08.040 humans [6,10,11], have been studied. However, reports on antimicrobial resistance profiles and the presence of class 1 integrons in E. coli O26 isolates of human and animal origin are scarce.…”

Survival and replication of Escherichia coli O157:H7 inside the mice peritoneal macrophages

“…Antibiotics and bacteriophages which destroy the bacteria were used to eliminate the extracellular bacteria (20). Elsinghorst (4) reported that gentamicin, could kill the extracellular bacteria without affecting the intracellular ones; but recently Oyha et al .…”