In Vitro Autoradiographic Localization of 125I-Secretin Receptor Binding Sites in Rat Brain

Nozaki, Satoshi; Nakata, Rika; Mizuma, Hiroshi; Nishimura, Nobuhiro; Watanabe, Yumiko; Kohashi, Ryuichiro; Watanabe, Yasuyoshi

doi:10.1006/bbrc.2002.6640

Cited by 35 publications

(23 citation statements)

References 10 publications

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“…Another gene secretin (SCT), located only 14 kb proximal to DRD4 (NCBI contig NT_008953), is a member of the VIP/glucagon family of neuropeptides. Its receptors have been found in the pituitary, hippocampus CA1 region, the pineal gland, and the cerebellum [Hannibal et al, 1995;Nussdorfer et al, 2000;Yung et al, 2001;Nozaki et al, 2002]. Secretin has been described anecdotally to improve symptoms of autism, but this effect was not replicated in randomized control trials [Sandler et al, 1999;Dunn-Geier et al, 2000].…”

Section: Discussionmentioning

confidence: 99%

A dyslexia susceptibility locus (DYX7) linked to dopamine D4 receptor (DRD4) region on chromosome 11p15.5

Hsiung

Kaplan

Petryshen

et al. 2003

American J of Med Genetics Pt B

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Dyslexia is a disability in acquiring reading and spelling skills that is independent of general intelligence and educational opportunity, and is highly heritable. It is known that dyslexia often co-occurs with attention deficit hyperactivity disorder (ADHD), and the 7-repeat allele of the 48-bp tandem repeat in exon 3 of the dopamine D4 receptor (DRD4) has been implicated in ADHD. We, therefore, investigated DRD4 as a candidate gene for dyslexia by testing for linkage and association with 14 markers at and around the DRD4 locus on chromosome 11p15.5. Using 100 families having at least two siblings affected with dyslexia, model-free linkage analysis revealed evidence for linkage to the DRD4-exon 3 repeat (two-point MFLOD = 2.27, P = 0.001) and to HRAS located just proximal to DRD4 (two-point MFLOD = 2.68, P = 0.0004). Evidence for linkage was maximal between DRD4 and HRAS (three-point MFLOD = 3.57, P = 0.00005). However, linkage disequilibrium analysis showed no significant evidence for association between dyslexia and DRD4 or HRAS. In particular, dyslexic subjects showed no significant increase of the DRD4 7-repeat allele associated with ADHD. It is possible that other DRD4 variants, not in strong linkage disequilibrium with the exon 3 repeat polymorphism, or alternatively, another gene very closely linked to DRD4, may influence susceptibility to dyslexia.

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Section: Discussionmentioning

confidence: 99%

A dyslexia susceptibility locus (DYX7) linked to dopamine D4 receptor (DRD4) region on chromosome 11p15.5

Hsiung

Kaplan

Petryshen

et al. 2003

American J of Med Genetics Pt B

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“…Most of the peptides in this group have been detected both peripherally and centrally, thereby reflecting their known hormonal role within the gastrointestinal system, and suggesting that they may also play a role in neuronal function. Furthermore, secretin receptors have been shown to be expressed in mammalian brain tissues, including the cerebellum (Fremeau et al, 1983;Nozaki et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Secretin induces neurite outgrowth of PC12 through cAMP-mitogen-activated protein kinase pathway

Kim

Yumkham²,

Kim

et al. 2006

Exp Mol Med

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The gastrointestinal functions of secretin have been fairly well established. However, its function and mode of action within the nervous system remain largely unclear. To gain insight into this area, we have attempted to determine the effects of secretin on neuronal differentiation. Here, we report that secretin induces the generation of neurite outgrowth in pheochromocytoma PC12 cells. The expressions of Tau and beta-tubulin, neuronal differentiation markers, are increased upon secretin stimulation. In addition, secretin induces sustained mitogen-activated protein kinase (MAPK) activation and also stimulates the cAMP secretion. Moreover, the neurite outgrowth elicited by secretin is suppressed to a marked degree in the presence of either PD98059, a specific MAPK/ERK kinase (MEK) inhibitor, or H89, a specific protein kinase A (PKA) inhibitor. Taken together, these observations demonstrate that secretin induces neurite outgrowth of PC12 cells through cAMP-MAPK pathway, and provide a novel insight into the manner in which secretin participates in neuritogenesis.

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“…Studies have shown that, not only is secretin located peripherally (in the gastrointestinal tract), but secretin and secretin receptors are also located centrally [Charlton et al, 1983;Yung et al, 2001;Koves et al, 2002;Nozaki et al, 2002;Welch et al, 2003;Kern et al, 2004;Welch et al, 2004;Yang et al, 2004]. Kern described secretin's potential role as a neuropeptide, with stimulation of receptors in the amygdala.…”

Section: Secretinmentioning

confidence: 99%

Novel treatments for autistic spectrum disorders

Levy

Hyman

2005

Ment. Retard. Dev. Disabil. Res. Rev.

144

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In no area of developmental pediatric practice is there more controversy regarding the choice of treatment than related to children with autistic spectrum disorders (ASD). Complementary and alternative medical therapies (CAM) are often elected because they are perceived as treating the cause of symptoms rather than the symptoms themselves. CAM used for autism can be divided by proposed mechanism: immune modulation, gastrointestinal, supplements that affect neurotransmitter function, and nonbiologic intervention. Secretin as a therapy for autism is discussed as an example of how a clinical observation rapidly grew to a widespread treatment before well-designed studies demonstrated absence of effect. The plausibility for behavioral effect was not substantiated by clinical studies. CAM used for treatment of autism is examined in terms of rationale, evidence of efficacy, side effects, and additional commentary. Families and clinicians need access to well-designed clinical evidence to assist them in choice of therapies.

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In Vitro Autoradiographic Localization of 125I-Secretin Receptor Binding Sites in Rat Brain

Cited by 35 publications

References 10 publications

A dyslexia susceptibility locus (DYX7) linked to dopamine D4 receptor (DRD4) region on chromosome 11p15.5

A dyslexia susceptibility locus (DYX7) linked to dopamine D4 receptor (DRD4) region on chromosome 11p15.5

Secretin induces neurite outgrowth of PC12 through cAMP-mitogen-activated protein kinase pathway

Novel treatments for autistic spectrum disorders

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