In vitro assessment of the relationship between acoustic properties and bone mass density of the calcaneus by comparison of ultrasound parametric imaging and quantitative computed tomography

Laugier, Pascal; Droin, P.; Laval-Jeantet, A. M.; Berger, G.

doi:10.1016/s8756-3282(96)00347-x

Cited by 165 publications

(82 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A scan of 60 ϫ 60 mm in steps of 1 mm is performed to obtain an image. 25,26 The measurements were performed underwater at a stable temperature of 30°C. A solution for reducing air bubbles and foaming reactions in the water, delivered by the manufacturer, was added.…”

Section: Ultrasound Measurementsmentioning

confidence: 99%

Speed of sound reflects Young’s modulus as assessed by microstructural finite element analysis

Bergh

Lenthe²,

Hermus

et al. 2000

Bone

View full text Add to dashboard Cite

We analyzed the ability of the quantitative ultrasound (QUS) parameter, speed of sound (SOS), and bone mineral density (BMD), as measured by dual-energy X-ray absorptiometry (DXA), to predict Young's modulus, as assessed by microstructural finite element analysis (FEA) from microcomputed tomography (CT) reconstructions. With FEA simulation, all bone elements in the model can be assigned the same isotropic Young's modulus; therefore, in contrast to mechanical tests, only the trabecular structure plays a role in the determination of the elastic properties of the specimen.

show abstract

Section: Ultrasound Measurementsmentioning

confidence: 99%

Speed of sound reflects Young’s modulus as assessed by microstructural finite element analysis

Bergh

Lenthe²,

Hermus

et al. 2000

Bone

View full text Add to dashboard Cite

show abstract

“…1-7 ͑Normalized broadband attenuation or nBUA is the slope of a line fit to the measured attenuation coefficient plotted as a function of frequency, a quantity sometimes referred to as the slope of attenuation.͒ Phase cancellation effects result in the overestimation of BUA, a quantity that has been shown to correlate with bone mineral density 1, [8][9][10][11][12][13][14] and therefore osteoporotic fracture risk. [15][16][17][18][19][20][21][22] Measurements of bone are complicated by many factors associated with their inhomogeneous character and irregular shapes, making it difficult to sort out potential physical mechanisms underlying phase aberration artifacts.…”

Section: Introductionmentioning

confidence: 99%

Bone sonometry: Reducing phase aberration to improve estimates of broadband ultrasonic attenuation

Bauer

Anderson

Holland

et al. 2009

The Journal of the Acoustical Society of America

View full text Add to dashboard Cite

Previous studies suggest that phase cancellation at the receiving transducer can result in the overestimation of the frequency dependent ultrasonic attenuation of bone, a quantity that has been shown to correlate with bone mineral density and ultimately with osteoporotic fracture risk. Evidence supporting this interpretation is provided by phase insensitive processing of the data, which appear to reduce the apparent overestimates of attenuation. The present study was designed to clarify the components underlying phase aberration artifacts in such through-transmission measurements by conducting systematic studies of the simplest possible test objects capable of introducing phase aberration. Experimental results are presented for a Lexan phantom over the frequency range 300-700 kHz and a Plexiglas phantom over the 3 -7 MHz range. Both phantoms were flat and parallel plates featuring a step discontinuity milled into one of their initially flat sides. The through-transmitted signals were received by a 0.6 mm diameter membrane hydrophone that was raster scanned over a grid coaxial with the transmitting transducer. Signals received by the pseudoarray were processed offline to emulate phase sensitive and phase insensitive receivers with different aperture diameters. The data processed phase sensitively were focused to demonstrate the results of planar, geometrical, and correlation-based aberration correction methods. Results are presented illustrating the relative roles of interference in the ultrasonic field and phase cancellation at the receiving transducer in producing phase aberration artifacts. It was found that artifacts due to phase cancellation or interference can only be minimized with phase insensitive summation techniques by choosing an appropriately large receiving aperture. Data also suggest the potentially confounding role of time-and frequency-domain artifacts on ultrasonic measurements and illustrate the advantages of two-dimensional receiving arrays in determining the slope of attenuation ͑nBUA͒ for the clinical assessment of osteoporosis.

show abstract

“…This extended analysis is already in widespread use in devices used in the investigation of different skeletal sites, notably the phalanges and, more recently, the calcaneus [3, 12, 13]. Figure 2 shows some of the parameters that can usually be derived from a graphic trace in clinical ultrasound studies of the phalanges.…”

Section: Second-generation Systemsmentioning

confidence: 99%

Assessment of Bone Architecture with Ultrasonometry: Experimental and Clinical Experience

et al. 2000

View full text Add to dashboard Cite

Over the last decade, ultrasound technology has been introduced as a method of analysing bone tissue in clinical practice, and several studies have compared various ultrasound devices with dual-energy X-ray absorptiometry (DXA). Unlike DXA, the ultrasound technique is not limited to the measurement of bone density – it also has the potential to provide information on the mechanical and architectural characteristics of bone. The first generation of ultrasound devices used the speed of sound and attenuation of the ultrasound signal to obtain information on bone mineral content. Second generation ultrasound devices, which analyse the ultrasound signal received, permit the study of bone structure and elasticity, in addition to its mineral content, in both experimental studies and clinical practice. This is accomplished by signal processing analysis, the study of backscattering and the application of Biot’s theory. This approach to the study of bone tissue represents the future for the development of ultrasound technology for use in clinical practice.

show abstract

In vitro assessment of the relationship between acoustic properties and bone mass density of the calcaneus by comparison of ultrasound parametric imaging and quantitative computed tomography

Cited by 165 publications

References 48 publications

Speed of sound reflects Young’s modulus as assessed by microstructural finite element analysis

Speed of sound reflects Young’s modulus as assessed by microstructural finite element analysis

Bone sonometry: Reducing phase aberration to improve estimates of broadband ultrasonic attenuation

Assessment of Bone Architecture with Ultrasonometry: Experimental and Clinical Experience

Contact Info

Product

Resources

About