In vitro assessment of Schistosoma mansoni cercaricidal activities of Solanum nigrum and Callistemon citrinius leaves extracts and cercarial genetic changes by RAPD-PCR

Abstract

RAPD technique developed by Williams et al., [14] was successfully used for fast and simple detection of genomic variations among parasites [15] , and the genetic polymorphisms involved in the mechanism of drug resistance [16,17]. Also, it provides a screening method to identify regions of genomic amplification, deletion, or rearrangement referred to genetic damage [18] .