In vitro assessment of hypocholesterolemic activity of Lactococcus lactis subsp. lactis

Shehata, Mohamed G.; El-Sahn, Malak A.; El-Sohaimy, Sobhy A.; Youssef, Mohamed M.

doi:10.1186/s42269-019-0090-1

Cited by 10 publications

(6 citation statements)

References 30 publications

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“…The high serum cholesterol level can be considerably managed through cholesterol lowering drugs but ends with side effects. The mechanisms behind cholesterol reduction by probiotic bacteria are as follows: (i) assimilation of cholesterol by growing bacterial cells, (ii) deconjugation of bile salts by bile salt hydrolase, (iii) precipitation of cholesterol with de-conjugated bile and (iv) binding of cholesterol to cells [114]. Very limited researches has been conducted on cholesterol lowering properties but in recent studies aiming at lowering blood cholesterol level through EPS of probiotic origin gained significant attention.…”

Section: Hypocholestrolemic and Antidiabetic Activitymentioning

confidence: 99%

Exopolysaccharides from probiotic bacteria and their health potential

Angelin

Kavitha

2020

International Journal of Biological Macromolecules

315

225

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Exopolysaccharides (EPS) are extracellular macromolecules excreted as tightly bound capsule or loosely attached slime layer in microorganisms. They play most prominent role against desiccation, phagocytosis, cell recognition, phage attack, antibiotics or toxic compounds and osmotic stress. In the last few decades, natural polymers have gained much attention among scientific communities owing to their therapeutic potential. In particular the EPS retrieved from probiotic bacteria with varied carbohydrate compositions possess a plenty of beneficial properties. Different probiotic microbes have unique behavior in expressing their capability to display significant health promoting characteristics in the form of polysaccharides. In this new era of alternative medicines, these polysaccharides are considered as substitutes for synthetic drugs. The EPS finds applications in various fields like textiles, cosmetics, bioremediation, food and therapeutics. The present review is focused on sources, chemical composition, biosynthetic pathways of EPS and their biological potential. More attention has been given to the scientific investigations on antimicrobial, antitumor, anti-biofilm, antiviral, anti-inflammatory and immunomodulatory activities.

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Section: Hypocholestrolemic and Antidiabetic Activitymentioning

confidence: 99%

Exopolysaccharides from probiotic bacteria and their health potential

Angelin

Kavitha

2020

International Journal of Biological Macromolecules

315

225

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“…Thus, these strains were able to remove cholesterol by inhibiting micelle formation [ 109 ]. Another mechanism whereby probiotics reduce cholesterolemia is the incorporation of cholesterol into bacterial cellular membranes [ 110 , 111 ]. Cholesterol assimilation was significantly higher in growing cells than resting and dead cells.…”

Section: Cholesterol-lowering Agentsmentioning

confidence: 99%

“…Both live and heat-killed Lactococcus lactis subsp. lactis N7 cells were able to remove cholesterol from growth media [ 111 ]. Subsequently, the gut microbiota plays a role on cholesterol conversion into coprostanol making it easily eliminable with defection and reducing its absorption [ 4 ].…”

Section: Cholesterol-lowering Agentsmentioning

confidence: 99%

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The Role of Gut Microbiota on Cholesterol Metabolism in Atherosclerosis

Vourakis

Mayer

Rousseau

2021

IJMS

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Hypercholesterolemia plays a causal role in the development of atherosclerosis and is one of the main risk factors for cardiovascular disease (CVD), the leading cause of death worldwide especially in developed countries. Current data show that the role of microbiota extends beyond digestion by being implicated in several metabolic and inflammatory processes linked to several diseases including CVD. Studies have reported associations between bacterial metabolites and hypercholesterolemia. However, such associations remain poorly investigated and characterized. In this review, the mechanisms of microbial derived metabolites such as primary and secondary bile acids (BAs), trimethylamine N-oxide (TMAO), and short-chain fatty acids (SCFAs) will be explored in the context of cholesterol metabolism. These metabolites play critical roles in maintaining cardiovascular health and if dysregulated can potentially contribute to CVD. They can be modulated via nutritional and pharmacological interventions such as statins, prebiotics, and probiotics. However, the mechanisms behind these interactions also remain unclear, and mechanistic insights into their impact will be provided. Therefore, the objectives of this paper are to present current knowledge on potential mechanisms whereby microbial metabolites regulate cholesterol homeostasis and to discuss the feasibility of modulating intestinal microbes and metabolites as a novel therapeutic for hypercholesterolemia.

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“…Furthermore, Baccouri et al [ 30 ] explained that the peptidoglycan cell wall of probiotic bacteria binds the cholesterol even to dead bacteria to decrease the levels. Moreover, Shehata et al [ 31 ] describe the cholesterol-binding mechanism related to exopolysaccharide activity in the media and the gut. In addition, Palaniyandi et al [ 22 ] enlighted the effect of hypercholesterolemia from L. fermentum MJM60397 related to bile acid deconjugation activity that led to decreasing bile acid absorption and increasing bile acid on feces, which makes the L. fermentum MJM60397 capable of being developed into a potential anti-hypercholesterol serum.…”

Section: Resultsmentioning

confidence: 99%

Effect of fermented milk Pediococcus acidilactici BK01 on cholesterol and microbiota in Wistar mice intestine

Melia¹,

Juliyarsi²,

Kurnia³

et al. 2023

J Adv Vet Anim Res

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Objective: This study examines the effect of fermented milk containing the probiotic Pediococcus acidilactici BK01 on cholesterol and intestinal microbiota. Materials and Methods: 24 male rats weighing an average of 200 gm each spent 1 week in a cage adapting to their new environment. They were fed standard feed daily and were allowed to drink ad libitum. For 3 weeks, rats were divided into four groups (doses of fermented milk): M+ (control), M1 (0.35 ml), M2 (0.70 ml), and M3 (1.05 ml). The analysis includes bodyweight deter¬mination, serum biochemical analysis, and intestine microbiota analysis. Results: The results indicated that while P. acidilactici BK01 fermented milk did not affect body weight or high-density lipoprotein, it did have a beneficial effect on total serum cholesterol and triglyceride levels. Additionally, treatment of fermented milk with P. acidilactici BK01 has been shown to increase the total lactic acid bacteria (LAB) in the intestine, as indicated by changes in the intestinal villi. Conclusion: Administering fermented milk (P. acidilactici BK01, 1.05 ml) can reduce total serum cholesterol and increase the number of LAB in intestinal villi in experimental animals, so it has the potential to be a probiotic.

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In vitro assessment of hypocholesterolemic activity of Lactococcus lactis subsp. lactis

Cited by 10 publications

References 30 publications

Exopolysaccharides from probiotic bacteria and their health potential

Exopolysaccharides from probiotic bacteria and their health potential

The Role of Gut Microbiota on Cholesterol Metabolism in Atherosclerosis

Effect of fermented milk Pediococcus acidilactici BK01 on cholesterol and microbiota in Wistar mice intestine

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