In Vitro Assessment of Charcoal and Resin Hemoadsorbents

Falkenhagen, D; Gottschall, S.; Esther, G.; Courtney, J. M.; Klinkmann, H

doi:10.1159/000406175

Cited by 16 publications

(9 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[23] HP also nonselectively adsorbs platelets, white blood cells, calcium, and glucose. [24] Further, a charcoal cartridge costs ten times more than a high-efficiency dialyzer, does not bind all poisons (e.g., alcohols and certain metals), and needs to be replaced every 2 h because of cartridge saturation, which decreases poison clearance. [25]…”

Section: Continuous Renal Replacement Therapy/sustained Low-efficiencmentioning

confidence: 99%

Extracorporeal treatment in the management of acute poisoning: What an intensivist should know?

Jha¹,

Padmaprakash²

2018

Indian Journal of Critical Care Medicine

View full text Add to dashboard Cite

Extracorporeal treatment (ECTR) represents a treatment modality promoting removal of endogenous or exogenous poisons and supporting or temporarily replacing a vital organ. This article aims to provide a brief overview of the technical aspects and the potential indications and limitations of the different ECTRs, highlighting the important characteristics of poison amenable to ECTR and the most appropriate prescriptions used in the setting of acute poisoning. The various principles that govern poison elimination by ECTR (diffusion, convection, adsorption, and centrifugation) and how components of the ECTR can be adjusted to maximize clearance have also being discussed.

show abstract

Section: Continuous Renal Replacement Therapy/sustained Low-efficiencmentioning

confidence: 99%

Extracorporeal treatment in the management of acute poisoning: What an intensivist should know?

Jha¹,

Padmaprakash²

2018

Indian Journal of Critical Care Medicine

View full text Add to dashboard Cite

show abstract

“…Coating reduces embolization of the particles and improves the biocompatibility of charcoal columns . However, coating can also reduce the in vitro clearance of several poisons, especially larger molecular weight compounds (>5000 Da) , although this has not been consistently observed in animal and human reports . In some publications, poison clearance using coated columns has even surpassed uncoated cartridges , although this could reflect other factors such as the structure of column.…”

Section: Charcoalmentioning

confidence: 99%

“…The more commonly reported adverse reactions are thrombocytopenia, leucopenia, hypocalcemia, hypophosphatemia, hypoglycemia, and a decrease in fibrinogen. On average, the platelet count will decrease 20–50% from its baseline value with any adsorption column . Fortunately, this decrease in platelet count is usually temporary and rarely contributes to bleeding complications, although these have been reported in large cohorts .…”

Section: Adverse Reactions To Hemoperfusionmentioning

confidence: 99%

“…Fortunately, this decrease in platelet count is usually temporary and rarely contributes to bleeding complications, although these have been reported in large cohorts . The decrease in white blood cell count is variable: it has been reported as high as 50% in some studies, and altogether absent in others . Electrolyte and glucose concentrations vary unpredictably during HP , but clinically significant hypoglycemia and life‐threatening arrhythmias are extremely rare.…”

Section: Adverse Reactions To Hemoperfusionmentioning

confidence: 99%

See 1 more Smart Citation

Hemoperfusion for the Treatment of Poisoning: Technology, Determinants of Poison Clearance, and Application in Clinical Practice

Ghannoum

Bouchard

Nolin

et al. 2014

Seminars in Dialysis

View full text Add to dashboard Cite

Hemoperfusion is an extracorporeal treatment based on adsorption, historically reserved for the treatment of acute poisonings. Its use was popularized in the 1970s after several in vitro and animal experiments had demonstrated its efficacy, and was even preferred over hemodialysis in the management of overdosed patients. With the advent of new and more efficient dialytic modalities, hemoperfusion is now less frequently performed in the Western world. However, hemoperfusion still remains popular in developing countries. The present article reviews the technique of hemoperfusion, the factors influencing poison clearance through adsorption and its current applications.

show abstract

“…35 HP also nonselectively adsorbs platelets, white blood cells, calcium, and glucose. 36,37 Further, a charcoal cartridge costs 10 times more than a high-efficiency dialyzer, 20 does not bind all poisons (e.g., alcohols and certain metals), 38 and needs to be replaced every 2 hours because of cartridge saturation, which decreases poison clearance. 39,40 Hemofiltration.…”

Section: Characteristics Of Poisons Amenable To Ectrmentioning

confidence: 99%