In vitro assessment of anticholinesterase and NADH oxidase inhibitory activities of an edible fern, <i>Diplazium esculentum</i>

Roy, Swarnendu; Dutta, S.; Chaudhuri, Tapas Kumar

doi:10.1515/jbcpp-2014-0100

Cited by 9 publications

(6 citation statements)

References 24 publications

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“…Various pharmacological properties of D. esculentum were previously reported [ 29 ]; however, none concentrated on BACE-1 inhibition. Nevertheless, its aqueous leaf extract significantly elevated locomotor activity and stimulated the central nervous system (CNS) in mice [ 30 ], while a 70% ( v / v ) methanolic extract inhibited AChE with an IC 50 value of 0.27 mg/mL [ 31 ], suggesting its potential as a source of anti-AD agents.…”

Section: Discussionmentioning

confidence: 99%

Impact of Drying Processes on Phenolics and In Vitro Health-Related Activities of Indigenous Plants in Thailand

Sirichai

Kittibunchakul

Thangsiri

et al. 2022

Plants

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Thailand has vast areas of tropical forests with many indigenous plants, but limited information is available on their phytochemical profile and in vitro inhibitions of enzymatic and nonenzymatic reactions. This study investigated phenolic profiles using liquid chromatography–electrospray ionization tandem mass spectrometry (LC–ESI-MS/MS), antioxidant activities, and in vitro inhibitory activities of 10 indigenous plants on key enzymes related to obesity (lipase), diabetes (α-amylase and α-glucosidase), and Alzheimer’s disease (cholinesterases and β-secretase). The nonenzymatic anti-glycation reaction was also investigated. The 10 indigenous plants were Albizia lebbeck (L.) Benth, Alpinia malaccensis (Burm.) Roscoe, Careya arborea Roxb., Diplazium esculentum (Retz.) Swartz, Kaempferia roscoeana Wall., Millettia brandisiana Kurz., Momordica charantia, Phyllanthus emblica L., Zingiber cassumunar Roxb, and Zingiber citriodorum J. Mood & T. Theleide. Preparations were made by either freeze-drying or oven-drying processes. Results suggested that the drying processes had a minor impact on in vitro inhibitions of enzymatic and nonenzymatic reactions (<4-fold difference). P. emblica was the most potent antioxidant provider with high anti-glycation activity (>80% inhibition using the extract concentration of ≤6 mg/mL), while D. esculentum effectively inhibited β-secretase activity (>80% inhibition using the extract concentration of 10 mg/mL). C. arborea exhibited the highest inhibitory activities against lipase (47–51% inhibition using the extract concentration of 1 mg/mL) and cholinesterases (>60% inhibition using the extract concentration of 2 mg/mL), while Mi. brandisiana dominantly provided α-amylase and α-glucosidase inhibitors (>80% inhibition using the extract concentration of ≤2 mg/mL). Information obtained from this research may support usage of the oven-drying method due to its lower cost and easier preparation step for these studied plant species and plant parts. Furthermore, the information on in vitro inhibitions of enzymatic and nonenzymatic reactions could be used as fundamental knowledge for further investigations into other biological activities such as cell culture or in vivo experiments of these health-beneficial plants.

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Section: Discussionmentioning

confidence: 99%

Impact of Drying Processes on Phenolics and In Vitro Health-Related Activities of Indigenous Plants in Thailand

Sirichai

Kittibunchakul

Thangsiri

et al. 2022

Plants

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“…The outcome of the study indicated that "pucukpaku" showed protective effects (62.9%) against cognitive decline. The anticholinesterase and NADH oxidase inhibitory activities of a methanolic extract of D. esculentum have been evaluated [83]. Recently, most of the studies reported that the inhibition of anticholinesterase has been shown to be a strategy for the treatment of neurodegenerative disorders.…”

Section: Oxidative Medicine and Cellular Longevitymentioning

confidence: 99%

Diplazium esculentum (Retz.) Sw.: Ethnomedicinal, Phytochemical, and Pharmacological Overview of the Himalayan Ferns

Semwal

Painuli

et al. 2021

Oxidative Medicine and Cellular Longevity

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The genus Diplazium (family: Athyriaceae) comprises approximately 350 species of pteridophytes. Diplazium esculentum (Retz.) Sw. is an important member of this genus and commonly known as a wild vegetable in the Himalayan and sub-Himalayan communities. According to the literature analysis, D. esculentum was traditionally used for the prevention or treatment of several diseases such as diabetes, smallpox, asthma, diarrhea, rheumatism, dysentery, headache, fever, wounds, pain, measles, hypertension, constipation, oligospermia, bone fracture, and glandular swellings. Various extracts of D. esculentum were evaluated to elucidate their phytochemical and pharmacological activities. A wide array of pharmacological properties such as antioxidant, antimicrobial, antidiabetic, immunomodulatory, CNS stimulant, and antianaphylactic activities have been recognized in different parts of D. esculentum. The review covers a systematic examination of pharmacognosy, phytochemistry, and pharmacological applications of D. esculentum, but scientifically, it is not fully assessed regarding complete therapeutic effects, toxicity, and safety in the human body. The published literature on D. esculentum and its therapeutic properties were collected from different search engines including Wiley online, PubMed, Springer Link, Scopus, Science Direct, Web of Science, Google Scholar, and ACS publications by using specific terms such as “Diplazium esculentum, bioactive compounds, biological activities and health benefits” from 1984 to 2021 (March). Therefore, further studies are required to identify the detailed action mechanism of D. esculentum in vitro/in vivo, and also, more studies should focus on conservation, cultivation, and sustainable utilization of the species.

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“… Relanodi Herb Leaves, stem Vertigo Antipsychotic properties [ 101 , 139 ] Athyriaceae Diplazium esculentum (Retz.) Sw Dhekishak Fern Leaves Headache, epilepsy, paralysis Cholinesterase and NADH oxidase inhibition [ 106 , 118 , 140 ] Begoniaceae Begonia silhetensis (A.DC.) C.B.Clarke Goni kanti Herb Leaves Headache NRE [ 89 ] Bignoniaceae Campsis radicans (L.) Seem Egro (Ma) Vine Leaves Headache (Ma) NRE [ 99 ] Crescentia cujete L. Jummu makal Tree Bark, fruit Brain disorder (Mental disorder) CNS depressant [ 141 , 142 ] Oroxylum indicum (L.) Benth.…”

Section: Introductionmentioning

confidence: 99%

Traditional Herbal Medicines Against CNS Disorders from Bangladesh

Uddin

Zidorn

2020

Nat. Prod. Bioprospect.

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The majority of the population in Bangladesh uses traditional plant-based medicines to manage various ailments, including central nervous system (CNS) disorders. This review presents ethnobotanical information and relevant scientific studies on plants used in traditional healthcare for the management of various CNS disorders in Bangladesh. The information on the medicinal plants of Bangladesh effective against CNS disorders published in scientific journals, books, and reports was compiled from different electronic databases using specific key words. The present article provides comprehensive information on a total of 224 medicinal plant species belonging to 81 families used for the treatment of CNS disorders by the various peoples of Bangladesh. In total, we reviewed more than 290 relevant papers. In this study, leaves were found as the most often used plant organ, followed by roots, fruits, whole plants, barks, seeds, stems, rhizomes, and flowers. The Fabaceae family contributes the highest number of used species, followed by Rubiaceae, Lamiaceae, Cucurbitaceae, Vitaceae, Euphorbiaceae, Malvaceae, and Zingiberaceae. The most frequently used species (in decreasing order) are Asparagus racemosus, Centella asiatica, Stephania japonica, Aegle marmelos, Coccinia grandis, Tabernaemontana divaricata, Bacopa monnieri, Abroma augusta, and Scoparia dulcis. This review may serve as a starting point for a rational search for neuroactive natural products against CNS disorders within the Flora of Bangladesh. Graphic Abstract

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In vitro assessment of anticholinesterase and NADH oxidase inhibitory activities of an edible fern, Diplazium esculentum

Cited by 9 publications

References 24 publications

Impact of Drying Processes on Phenolics and In Vitro Health-Related Activities of Indigenous Plants in Thailand

Impact of Drying Processes on Phenolics and In Vitro Health-Related Activities of Indigenous Plants in Thailand

Diplazium esculentum (Retz.) Sw.: Ethnomedicinal, Phytochemical, and Pharmacological Overview of the Himalayan Ferns

Traditional Herbal Medicines Against CNS Disorders from Bangladesh

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