2002
DOI: 10.1128/cdli.9.4.919-920.2002
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In Vitro Assessment of Antiborrelial Activity of OspA Vaccine Sera

Abstract: Prevention of Lyme disease by the recombinant OspA-based vaccine reportedly works by preventing transmission of spirochetes from ticks to humans. We report on an in vitro microculture assay, which can be used to provide an indicator of the need for booster doses of vaccine.To date, there is no commercially available assay for assessing whether a recipient of the recombinant OspA-based vaccine for Lyme disease possesses adequate antiborrelial activity to prevent transmission of Borrelia burgdorferi from ticks (… Show more

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