In-Vitro Application of a Qatari Burkholderia cepacia strain (QBC03) in the Biocontrol of Mycotoxigenic Fungi and in the Reduction of Ochratoxin A biosynthesis by Aspergillus carbonarius

Zeidan, Randa; Hassan, Zahoor Ul; Al‐Thani, Roda; Migheli, Quirico; Jaoua, Samir

doi:10.3390/toxins11120700

Cited by 20 publications

(19 citation statements)

References 34 publications

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“…In addition, GC×GC-TOFMS results show that the production of fatty acids such as linoleic, Fungal melanin has attracted interest due to its potential usage in many industries including nanotechnology, biomedicine, dermo-cosmetics, and materials science [56]. However, Aspergillus carbonarius is also known as a producer of ochratoxin A (OTA) [74]. For this reason, further research on melanin production, OTA level and physical OTA removal methods such as filtration and pressure needs to be undertaken.…”

Section: Characterization Of Fungal Biomassmentioning

confidence: 99%

Production of Bio-Based Pigments from Food Processing Industry By-Products (Apple, Pomegranate, Black Carrot, Red Beet Pulps) Using Aspergillus carbonarius

Arikan

Canlı

Caro³

et al. 2020

JoF

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Food processing industry by-products (apple, pomegranate, black carrot, and red beet pulps) were evaluated as raw materials in pigment production by the filamentous fungi Aspergillus carbonarius. The effect of fermentation conditions (solid and submerged-state), incubation period (3, 6, 9, 12, and 15 d), initial substrate pH (4.5, 5.5, 6.5, 7.5, and 8.5), and pulp particle size (<1.4, 1.4–2.0, 2–4, and >4 mm) on fungal pigment production were tested to optimize the conditions. Pigment extraction analysis carried out under solid-state fermentation conditions showed that the maximum pigment production was determined as 9.21 ± 0.59 absorbance unit at the corresponding wavelength per gram (AU/g) dry fermented mass (dfm) for pomegranate pulp (PP) by A. carbonarius for 5 d. Moreover, the highest pigment production was obtained as 61.84 ± 2.16 AU/g dfm as yellowish brown at initial pH 6.5 with < 1.4 mm of substrate particle size for 15-d incubation period. GC×GC-TOFMS results indicate that melanin could be one of the main products as a pigment. SEM images showed that melanin could localize on the conidia of A. carbonarius.

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Section: Characterization Of Fungal Biomassmentioning

confidence: 99%

Production of Bio-Based Pigments from Food Processing Industry By-Products (Apple, Pomegranate, Black Carrot, Red Beet Pulps) Using Aspergillus carbonarius

Arikan

Canlı

Caro³

et al. 2020

JoF

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“…The results indicated that QBC03 culture supernatant acted inhibitory to the growth of Aspergillus carbonarius , Fusarium culmorum , and P. verrucosum . Synthesis of ochratoxin A by A. carbonarius was also reduced [ 168 ]. De Melo Nazareth et al reported that Lactobacillus plantarum CECT 749 CFS showed a high antifungal effect against A. flavus and F. verticillioides on corn kernels and corn ears, and FB1 and AFB1 levels were significantly reduced [ 169 ].…”

Section: Bio-acceptable Solutions For Fungal Control and Detoxification Of Mycotoxinsmentioning

confidence: 99%

“…Bacteria [162][163][164][165][166][167][168][169][170][171] Yeast [172][173][174][175][176][177][178] Fungi [1,163,179,180] Commercial agents [181] Preharvest agronomical strategies Agro-technical measures…”

Section: Microbiological Approach Microorganismsmentioning

confidence: 99%

Mycotoxins Biocontrol Methods for Healthier Crops and Stored Products

Habschied

Krstanović

Babić

et al. 2021

JoF

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Contamination of crops with phytopathogenic genera such as Fusarium, Aspergillus, Alternaria, and Penicillium usually results in mycotoxins in the stored crops or the final products (bread, beer, etc.). To reduce the damage and suppress the fungal growth, it is common to add antifungal substances during growth in the field or storage. Many of these antifungal substances are also harmful to human health and the reduction of their concentration would be of immense importance to food safety. Many eminent researchers are seeking a way to reduce the use of synthetic antifungal compounds and to implement more eco-friendly and healthier bioweapons against fungal proliferation and mycotoxin synthesis. This paper aims to address the recent advances in the effectiveness of biological antifungal compounds application against the aforementioned fungal genera and their species to enhance the protection of ecological and environmental systems involved in crop growing (water, soil, air) and to reduce fungicide contamination of food derived from these commodities.

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“…Biotechnological strategies are widely used in eliminating OTA because it is environmentally friendly and effective. Several biocontrol strains like Burkholderia cepacia , Brevibacterium casei , Aspergillus niger , and Alcaligenes faecalis were researched and evaluated with varying degrees of success [ 20 , 21 , 22 , 23 , 24 ]. The direct degradation of OTA to a less toxic substance ochratoxin α (OTα) is the most significant mechanism [ 22 ], but some microorganisms can also have antifungal properties and inhibit OTA production [ 25 , 26 ].…”

Section: Introductionmentioning

confidence: 99%

Bacillus subtilis ANSB168 Producing d-alanyl-d-alanine Carboxypeptidase Could Alleviate the Immune Injury and Inflammation Induced by Ochratoxin A

Qing

Huo

Huang

et al. 2021

IJMS

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Ochratoxin A (OTA) is toxic to animals and threatens food safety through residues in animal tissues. A novel degrading strain Bacillus subtilis ANSB168 was isolated and further investigated. We cloned d-alanyl-d-alanine carboxypeptidase DacA and DacB from ANSB168 and over-expressed them in Escherichia coli Rosetta (DE3). Then, we characterized the OTA degradation mechanism of DacA and DacB, which was degrading OTA into OTα. A total of 45 laying hens were divided into three equal groups. The control group was fed basal feed, and other groups were administered with OTA (250 μg/kg of feed). A freeze-dried culture powder of ANSB168 (3 × 107 CFU/g, 2 kg/T of feed) was added to one of the OTA-fed groups for 28 days from day one of the experiment. We found that OTA significantly damaged the kidney and liver, inducing inflammation and activating the humoral immune system, causing oxidative stress in the layers. The ANSB168 bioproduct was able to alleviate OTA-induced kidney and liver damage, relieving OTA-induced inflammation and oxidative stress. Overall, DacA and DacB derived from ANSB168 degraded OTA into OTα, while the ANSB168 bioproduct was able to alleviate damages induced by OTA in laying hens.

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In-Vitro Application of a Qatari Burkholderia cepacia strain (QBC03) in the Biocontrol of Mycotoxigenic Fungi and in the Reduction of Ochratoxin A biosynthesis by Aspergillus carbonarius

Cited by 20 publications

References 34 publications

Production of Bio-Based Pigments from Food Processing Industry By-Products (Apple, Pomegranate, Black Carrot, Red Beet Pulps) Using Aspergillus carbonarius

Production of Bio-Based Pigments from Food Processing Industry By-Products (Apple, Pomegranate, Black Carrot, Red Beet Pulps) Using Aspergillus carbonarius

Mycotoxins Biocontrol Methods for Healthier Crops and Stored Products

Bacillus subtilis ANSB168 Producing d-alanyl-d-alanine Carboxypeptidase Could Alleviate the Immune Injury and Inflammation Induced by Ochratoxin A

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