In vitro apatite formation on polyamide containing carboxyl groups modified with silanol groups

Kawai, Takeshi; Ohtsuki, Chikara; Kamitakahara, Masanobu; Hosoya, Kayo; Tanihara, Masao; Miyazaki, Toshiki; Sakaguchi, Yoshimitsu; Konagaya, Shigeji

doi:10.1007/s10856-006-0081-2

Cited by 30 publications

(25 citation statements)

References 14 publications

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“…Therefore, it is concluded that in addition to providing additional oxygen atoms, which reduce the N c , the −OH groups play a far more significant role in terms of the bioactivity even at relatively low concentrations. This is in agreement with studies of apatite deposition on titanium that has been modified to have high concentrations of Ti-OH [44] at the surface and polymers with high concentrations of surface −COOH groups [45].…”

Section: (C) Atomic Structure Of Sol-gel-derived Bioactive Glasssupporting

confidence: 91%

Characterizing the hierarchical structures of bioactive sol–gel silicate glass and hybrid scaffolds for bone regeneration

Martin

Sheng

Hanna

et al. 2012

Phil. Trans. R. Soc. A.

122

106

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Bone is the second most widely transplanted tissue after blood. Synthetic alternatives are needed that can reduce the need for transplants and regenerate bone by acting as active temporary templates for bone growth. Bioactive glasses are one of the most promising bone replacement/regeneration materials because they bond to existing bone, are degradable and stimulate new bone growth by the action of their dissolution products on cells. Sol-gel-derived bioactive glasses can be foamed to produce interconnected macropores suitable for tissue ingrowth, particularly cell migration and vascularization and cell penetration. The scaffolds fulfil many of the criteria of an ideal synthetic bone graft, but are not suitable for all bone defect sites because they are brittle. One strategy for improving toughness of the scaffolds without losing their other beneficial properties is to synthesize inorganic/organic hybrids. These hybrids have polymers introduced into the sol-gel process so that the organic and inorganic components interact at the molecular level, providing control over mechanical properties and degradation rates. However, a full understanding of how each feature or property of the glass and hybrid scaffolds affects cellular response is needed to optimize the materials and ensure long-term success and clinical products. This review focuses on the techniques that have been developed for characterizing the hierarchical structures of sol-gel glasses and hybrids, from atomicscale amorphous networks, through the covalent bonding between components in hybrids and nanoporosity, to quantifying open macroporous networks of the scaffolds. Methods for non-destructive in situ monitoring of degradation and bioactivity mechanisms of the materials are also included.

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Section: (C) Atomic Structure Of Sol-gel-derived Bioactive Glasssupporting

confidence: 91%

Characterizing the hierarchical structures of bioactive sol–gel silicate glass and hybrid scaffolds for bone regeneration

Martin

Sheng

Hanna

et al. 2012

Phil. Trans. R. Soc. A.

122

106

View full text Add to dashboard Cite

show abstract

“…One method is to functionalize the biomaterial surface with reactive groups like Si-OH [29], Ti-OH [30], COO- [31], -SO 3 H [32] that would provide nucleation sites for apatite formation. In this regard, some functional groups might be more potent than others in their ability to nucleate apatite crystals.…”

Section: Discussionmentioning

confidence: 99%

Multiple factor interactions in biomimetic mineralization of electrospun scaffolds

et al. 2009

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“…Therefore, surface engineering of polymers is an interesting way to modify the material and biological responses [12]. There have been several ways to improve the bioactivity of PA for bone repair, such as compounding with bioactive inorganic particles [8,13], grafting with bioactive groups [14] and forming bioactive coatings [5,15]. Compared with the first two methods, bioactive coating is a relatively facile and low-cost technique.…”

Section: Introductionmentioning

confidence: 99%

Interfacial and biological properties of the gradient coating on polyamide substrate for bone substitute

Huang

Niu

Wei

et al. 2014

J. R. Soc. Interface.

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Fabrication of bioactive and mechanical matched bone substitutes is crucial for clinical application in bone defects repair. In this study, nano-hydroxyapatite/ polyamide (nHA/PA) composite was coated on injection-moulded PA by a chemical corrosion and phase-inversion technique. The shear strength, gradient composition and pore structure of the bioactive coating were characterized. Osteoblast-like MG63 cells were cultured on pure PA and composite-coated PA samples. The cells' adhesion, spread and proliferation were determined using MTT assay and microscopy. The results confirm that the samples with the nHA/PA composite coating have better cytocompatibility and have no negative effects on cells. To investigate the in vivo biocompatibility, both pure PA and composite-coated PA cylinders were implanted in the trochlea of rabbit femurs and studied histologically, and the bonding ability with bone were determined using push-out tests. The results show that composite-coated implants exhibit better biocompatibility and the shear strength of the composite-coated implants with host bone at 12 weeks can reach 3.49 + 0.42 MPa, which is significantly higher than that of pure PA implants. These results indicate that composite-coated PA implants have excellent biocompatibility and bonding abilities with host bone and they have the potential to be applied in repair of bone defects.

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In vitro apatite formation on polyamide containing carboxyl groups modified with silanol groups

Cited by 30 publications

References 14 publications

Characterizing the hierarchical structures of bioactive sol–gel silicate glass and hybrid scaffolds for bone regeneration

Characterizing the hierarchical structures of bioactive sol–gel silicate glass and hybrid scaffolds for bone regeneration

Multiple factor interactions in biomimetic mineralization of electrospun scaffolds

Interfacial and biological properties of the gradient coating on polyamide substrate for bone substitute

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