In vitro antiproliferative evaluation of underground organs essential oil and fractions of Aldama arenaria Baker

Oliveira, Adriana Passos; Rehder, Vera Lúcia Garcia; Ruiz, Ana Lúcia T. G.; Longato, Giovanna Barbarini; Carvalho, JE de; Oliveira, Tatiana de Paula; Glória, Beatriz Appezzato da; Imamura, Paulo M.

doi:10.1055/s-0034-1395010

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Figure No 1 Structures Of Ent-pimara-8(14)15-dien-19-oic Acid (1) and Ent-8(14)15-pimaradien-3β-ol (2)1

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2021

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“…Research has also shown the antiprotozoal activities of three entpimarane compounds isolated from Aldama discolor (Nogueira et al, 2016). Recent work by our research group has revealed the potential in vitro antiproliferative activity of this species (Oliveira et al, 2013;Oliveira et al, 2014).…”

Section: Figure No 1 Structures Of Ent-pimara-8(14)15-dien-19-oic Acid (1) and Ent-8(14)15-pimaradien-3β-ol (2)mentioning

confidence: 97%

Antiproliferative activity from Aldama arenaria (Baker) E. E. Schill. & Panero

Oliveira¹,

Imamura²,

Ruiz³

et al. 2021

BLACPMA

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Chloroform extract (CE) and fractions obtained from Aldama arenariaroots were evaluated for their in vitroantiproliferative activity against 10 human tumor cell lines [leukemia (K-562), breast (MCF-7), ovary expressing a multidrug-resistant phenotype (NCI/ADR-RES), melanoma (UACC-62), lung (NCI-H460), prostate (PC-3), colon (HT29), ovary (OVCAR-3), glioma (U251), and kidney (786-0)]. CE presented weak to moderate antiproliferative activity (mean log GI501.07), whereas fractions 3 and 4, enriched with pimarane-type diterpenes [ent-pimara-8(14),15-dien-19-oic acid and ent-8(14),15-pimaradien-3β-ol], presented moderate to potent activity for most cell lines, with mean log GI50of 0.62 and 0.59, respectively. The results showed promising in vitroantiproliferative action of the samples obtained from A. arenaria, with the best results for NCI/ADR-RES, HT29, and OVCAR-3, and TGI values ranging from 5.95 to 28.71 μg.mL-1, demonstrating that compounds of this class may be potential prototypes for the discovery of new therapeutic agents.

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Section: Figure No 1 Structures Of Ent-pimara-8(14)15-dien-19-oic Acid (1) and Ent-8(14)15-pimaradien-3β-ol (2)mentioning

confidence: 97%