In vitro antiproliferative/cytotoxic activity of 2,3ʹ-biindole againstvarious cancer cell lines

Ökten, Salih; Erenler, Ram­azan; Köprülü, Tuğba Kul; Teki̇n, Şaban

doi:10.3906/biy-1402-60

Cited by 16 publications

(10 citation statements)

References 48 publications

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“…Human topoisomerase I is an essential enzyme that plays an important role in DNA replication and transcription and has been identified as the potential target of several anticancer drugs. [29] During transcription and replication, Topo I unravels twist in order for DNA metabolic processes. Some agents, called topoisomerase inhibitors, have been identified to work by inhibiting the activity of topoisomerase.…”

Section: Topoisomerase I Inhibitionmentioning

confidence: 99%

Biological evaluation of some quinoline derivatives with different functional groups as anticancer agents

Köprülü

Ökten

Teki̇n³

et al. 2018

J Biochem & Molecular Tox

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Due to a great deal of biological activities, quinoline derivatives have drawn attention for synthesis and biological activities in the search for new anticancer drug development. In this work, a variety of substituted (phenyl, nitro, cyano, N‐oxide, and methoxy) quinoline derivatives (3‐13) were tested in vitro for their biological activity against cancer cell lines, including rat glioblastoma (C6), human cervical cancer cells (HeLa), and human adenocarcinoma (HT29). 6‐Bromo‐5‐nitroquinoline (4), and 6,8‐diphenylquinoline (compound 13) showed the greatest antiproliferative activity as compared with the reference drug, 5‐fluorouracil (5‐FU), while the other compounds showed low antiproliferative activity. 6‐Bromo‐5‐nitroquinoline (4) possesses lower cytotoxic activity than 5‐FU in HT29 cell line. Due to its the apoptotic activity 6‐Bromo‐5‐nitroquinoline (4) has the potential to cause cancer cell death.

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Section: Topoisomerase I Inhibitionmentioning

confidence: 99%

Biological evaluation of some quinoline derivatives with different functional groups as anticancer agents

Köprülü

Ökten

Teki̇n³

et al. 2018

J Biochem & Molecular Tox

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“…The mechanism suggested for sanguinarine-induced apoptosis is based on the activation of caspases regulated by different proteins, including members of the Bcl-2 family (Lee et al, 2012). However, the mechanism of antiproliferative action of various anticancer compounds may or may not involve apoptosis (Ökten et al, 2015;Vejselova and Kutlu, 2015).…”

Section: Introductionmentioning

confidence: 99%

The cytotoxic activity of sanguinarine in C32 human amelanotic melanoma cells

Cojocaru¹,

Stan²,

Anton³

et al. 2016

Turk J Biol

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Sanguinarine, an alkaloid present in various medicinal plants, has been associated with detrimental effects on different types of cancer cells. The aim of our study was to analyze the cytotoxic effects of sanguinarine on C32 human amelanotic melanoma cells. The cells were exposed to various concentrations of sanguinarine (0.5, 1, and 2 µM) for 24 h and displayed a dose-dependent decrease in cell viability; the sanguinarine-induced oxidative stress in C32 cells affected the activity of antioxidant enzymes and generated lipid peroxidation. Moreover, we observed an enhanced expression of heat shock proteins 60, 70, and 90 in response to the stress exerted by this alkaloid. The increased p53 protein expression and Bax/Bcl-2 ratio revealed the susceptibility of C32 cells to apoptosis. Our study demonstrated that sanguinarine induced cytotoxicity in melanoma cells that ultimately resulted in cell death. These results emphasize the antigrowth efficiency of sanguinarine against amelanotic melanoma cells, but further research is needed in order to obtain more potent antitumor effects of this alkaloid.

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“…Nearly 5 × 10 3 cells in 100 µL were placed into microtiter plates and reacted with diverse concentrations of C. fracta extracts. LDH activity was detected at 492 -630 nm using a microplate reader [14]. The cytotoxicity results were calculated by Eq 2.…”

Section: Evaluation Of Cytotoxic Activitymentioning

confidence: 99%

Fatty acid constituents and anticancer activity of <i>Cladophora fracta</i> (OF Müller ex Vahl) Kützing

Karan¹,

Erenler²

2019

Trop. J. Pharm Res

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Purpose: To determine the fatty acid constituents and anticancer effect of Cladohora fracta Methods: Cladophora fracta (O.F. Müller ex Vahl) Kützing was collected from natural ponds in Tokat, Turkey. Antiproliferative and cytotoxic effects of methanol and hexane extracts of C. fracta were investigated on human colon carcinoma (HT29) and non-tumorigenic African green monkey kidney (Vero) cell lines using BrdU cell proliferation enzyme-linked Immunosorbent assay (ELISA) and lactate dehydrogenase (LDH) test, respectively. The fatty acid composition of hexane extract was analyzed by gas chromatography-mass spectrometry (GC-MS). Results: Oleic acid, palmitic acid, gamma-linoleic acid and linoleic acid were the main constituents of C. fracta. The methanol extract exhibited strong antiproliferative activity on HT29 and Vero cell lines (p < 0.05). The hexane extract revealed its good antiproliferative activity at high concentrations on both cell lines. Cytotoxicity results showed that both methanol and hexane extract had low effect on HT29 cell at low concentrations. Conclusion: Due to the strong antiproliferative effect of C. fracta methanol extract on HT29 and Vero cell lines, it has potential anticancer properties and recommended for further development as such.

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In vitro antiproliferative/cytotoxic activity of 2,3ʹ-biindole againstvarious cancer cell lines

Cited by 16 publications

References 48 publications

Biological evaluation of some quinoline derivatives with different functional groups as anticancer agents

Biological evaluation of some quinoline derivatives with different functional groups as anticancer agents

The cytotoxic activity of sanguinarine in C32 human amelanotic melanoma cells

Fatty acid constituents and anticancer activity of <i>Cladophora fracta</i> (OF Müller ex Vahl) Kützing

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