In vitro antiplasmodial, molecular docking and pharmacokinetics studies of specialized metabolites from Tetrapleura tetraptera (Fabaceae)

Sikam, Klev Gaïtan; Happi, Gervais Mouthé; Ahmed, Sikiru Akinyeye; Wakeu, Brussine Nadege Kweka; Meikeu, Livine Zemo; Salau, Shina; Wansi, Jean Duplex

doi:10.1016/j.sajb.2022.11.021

Cited by 10 publications

(7 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Its use in malaria treatment is no exception, as it possesses antiplasmodial activity [ 18 ]. [ 56 , 57 ] reported the use of T. tetraptera extract in treating malaria in Gabon and Cameroon ([ 56 , 57 ]. Methanolic extract of the bark and roots of T. tetraptera inhibited the growth of Plasmodium falciparum 3D7 at 83.6 and 76.3% respectively [ 57 ].…”

Section: Resultsmentioning

confidence: 99%

“…[ 56 , 57 ] reported the use of T. tetraptera extract in treating malaria in Gabon and Cameroon ([ 56 , 57 ]. Methanolic extract of the bark and roots of T. tetraptera inhibited the growth of Plasmodium falciparum 3D7 at 83.6 and 76.3% respectively [ 57 ]. Different groups of phytoconstituents are known to possess antimalarial properties.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Nutritive value, biological properties, health benefits and applications of Tetrapleura tetraptera: An updated comprehensive review

Mensah,

Adusei,

Azupio

et al. 2024

Heliyon

View full text Add to dashboard Cite

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Nutritive value, biological properties, health benefits and applications of Tetrapleura tetraptera: An updated comprehensive review

Mensah,

Adusei,

Azupio

et al. 2024

Heliyon

View full text Add to dashboard Cite

“…The second triterpene ursolic acid ( 4 ) was obtained from the active fraction with a yield of 0.1% and a potency in terms of IC 50 equal to 11.8 ± 3.2 μ g/mL and the lowest SI of 0.2. Our recent report on the investigations of Cameroonian medicinal plants for their antiplasmodial metabolites indicated that ursolic acid ( 4 ) possessed a weak antiplasmodial potency and inhibited the Plasmodium parasite through interactions with Plasmodium dihydroorotate dehydrogenase indicating important residue-hydrogen bond interactions with ASN274 (3.07), CYS276 (3.00), and GLY277 (2.32) [ 7 ].…”

Section: Resultsmentioning

confidence: 99%

“…The antiplasmodial evaluation of the fractions and pure compounds has been done following the protocol described in our recent publication [ 7 ].…”

Section: Methodsmentioning

confidence: 99%

Bioassay‐Guided Isolation of Antiplasmodial Compounds from Hypericum lanceolatum Lam. (Hypericaceae) and Their Cytotoxicity and Molecular Docking

Happi

Ahmed

Kemayou

et al. 2023

BioMed Research International

Self Cite

View full text Add to dashboard Cite

In Cameroon, malaria is still the cause of several deaths yearly and leading to the continued search for new potent leads to fight against Plasmodium falciparum. Medicinal plants like Hypericum lanceolatum Lam. are introduced in local preparations for the treatment of affected people. The bioassay-guided fractionation of the crude extract of the twigs and stem bark of H. lanceolatum Lam. led to the identification of the dichloromethane-soluble fraction as the most active (with 32.6% of the parasite P. falciparum 3D7 survival) which was further purified by successive column chromatography to obtain four compounds identified by their spectrometric data as two xanthones 1,6-dihydroxyxanthone (1) and norathyriol (2) and two triterpenes betulinic acid (3) and ursolic acid (4). In the antiplasmodial assay against P. falciparum 3D7, the triterpenoids 3 and 4 displayed the most significant potencies with IC50 values of 2.8 ± 0.8 μg/mL and 11.8 ± 3.2 μg/mL, respectively. Furthermore, both compounds were also the most cytotoxic against P388 cell lines with IC50 values of 6.8 ± 2.2 μg/mL and 2.5 ± 0.6 μg/mL, respectively. Further insights on the inhibition method of the bioactive compounds and their drug-likeness were obtained from their molecular docking and ADMET studies. The results obtained help in identifying additional antiplasmodial agents from H. lanceolatum and support its use in folk medicine for the treatment of malaria. The plant might be considered as a promising source of new antiplasmodial candidates in new drug discovery.

show abstract

“…The structural elucidation of the isolated compounds has been done with the aid of their spectrometric data including 1D-, 2D-NMR and MS, as well as by their comparison with those found in the literature (Supplementary information is given in Appendix A). This exercise allowed us to identify the isolates as one triterpenoid called aridanin (1) (Sikam et al, 2022).…”

Section: Phytochemical Studymentioning

confidence: 99%

Chemical constituents of Citrus grandis (L.) Osbeck (Rutaceae) and their α-glucosidase inhibitory activity

Ngolong,

Tabekoueng,

Mouthé Happi

et al. 2024

NRFHH

Self Cite

View full text Add to dashboard Cite

The chemical investigation of the methanolic bark extract of Citrus grandis (L.) Osbeck (Rutaceae) led to the isolation of one saponin named aridanin (1) isolated for the first time in the genus Citrus, together with seventeen known compounds including eight acridone-type alkaloids, two limonoids, two coumarins, one sugar, one lactam derivative, and three common steroids. Their structures were conclusively established using 1D- and 2D-NMR spectral data. The isolated compounds 1-9 were tested for their α-glucosidase inhibitory activity and the results showed that they all have potency higher than the reference acarbose (IC50 = 218.2 ± 2.8 μM) and aridanin was the strongest one which could be due to its sugar unit as usually observed for triterpene saponins. Furthermore, the structure-activity relationship of the tested compounds has been discussed as well as the chemotaxonomic significance of the study. The present study enriches the chemistry of Citrus with three additional compounds (1, 14, 15) and classifies the plant C. grandis as a good source of leads for the development of anti-diabetic drugs.

show abstract

In vitro antiplasmodial, molecular docking and pharmacokinetics studies of specialized metabolites from Tetrapleura tetraptera (Fabaceae)

Cited by 10 publications

References 35 publications

Nutritive value, biological properties, health benefits and applications of Tetrapleura tetraptera: An updated comprehensive review

Nutritive value, biological properties, health benefits and applications of Tetrapleura tetraptera: An updated comprehensive review

Bioassay‐Guided Isolation of Antiplasmodial Compounds from Hypericum lanceolatum Lam. (Hypericaceae) and Their Cytotoxicity and Molecular Docking

Chemical constituents of <i>Citrus grandis</i> (L.) Osbeck (Rutaceae) and their α-glucosidase inhibitory activity

Contact Info

Product

Resources

About