In vitro antiplasmodial, antitrypanosomal and antileishmanial activities of selected medicinal plants from Ugandan flora: Refocusing into multi-component potentials

Obbo, C.J.D.; Kariuki, S. T.; Gathirwa, Jeremiah; Olaho-Mukani, W.; Cheplogoi, Peter K.; Mwangi, Eric

doi:10.1016/j.jep.2018.09.029

Cited by 25 publications

(17 citation statements)

References 78 publications

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“…Some studies have been performed on antiplasmodial/antimalarial activities of some of the herbal plants used in Uganda to treat malaria by using various strains of malarial parasites to confirm effectiveness as malaria treatment [26, 28]. Furthermore, a broad range of phytochemicals responsible for biological activities in some of the antimalarial herbs have been isolated and identified [23].…”

Section: Antimalarial Activities and Toxicity Of Herbs Used In Ugamentioning

confidence: 99%

Exploring Antimalarial Herbal Plants across Communities in Uganda Based on Electronic Data

Okello

Kang

2019

Evidence-Based Complementary and Alternative Medicine

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Malaria is one of the most rampant diseases today not only in Uganda but also throughout Africa. Hence, it needs very close attention as it can be severe, causing many deaths, especially due to the rising prevalence of pathogenic resistance to current antimalarial drugs. The majority of the Ugandan population relies on traditional herbal medicines for various health issues. Thus, herein, we review various plant resources used to treat malaria across communities in Uganda so as to provide comprehensive and valuable ethnobotanical data about these plants. Approximately 182 plant species from 63 different plant families are used for malaria treatment across several communities in Uganda, of which 112 plant species have been investigated for antimalarial activities and 96% of the plant species showing positive results. Some plants showed very strong antimalarial activities and could be investigated further for the identification and validation of potentially therapeutic antimalarial compounds. There is no record of an investigation of antimalarial activity for approximately 39% of the plant species used for malaria treatment, yet these plants could be potential sources for potent antimalarial remedies. Thus, the review provides guidance for areas of further research on potential plant resources that could be sources of compounds with therapeutic properties for the treatment of malaria. Some of the plants were investigated for antimalarial activities, and their efficacy, toxicity, and safety aspects still need to be studied.

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Section: Antimalarial Activities and Toxicity Of Herbs Used In Ugamentioning

confidence: 99%

Exploring Antimalarial Herbal Plants across Communities in Uganda Based on Electronic Data

Okello

Kang

2019

Evidence-Based Complementary and Alternative Medicine

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“…[35][36][37] For this reason, several research groups from medicinal chemistry, pharmacy, and infection biology focus on the search of new effective agents for the treatment of tropical infectious diseases. In the recent years, intense phytochemical studies on African plants have led to the discovery of terpenoids, alkaloids, avonoids, quinones, lignans, coumarins, and many other natural products displaying excellent antiprotozoal activities, [38][39][40][41][42][43][44][45] thus providing templates and new scaffolds for the development of a new generation of more potent drugs. Most promising sources for such lead compounds are Ancistrocladus species from Central Africa.…”

Section: View Article Onlinementioning

confidence: 99%

Antiprotozoal dimeric naphthylisoquinolines, mbandakamines B₃ and B₄, and related 5,8′-coupled monomeric alkaloids, ikelacongolines A–D, from a Congolese Ancistrocladus liana

et al. 2019

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“…ex Walp.) Isawumi Backbone pain Leaves, roots and stems Ethiopia and South Africa [20][21][22] Diabetes Leaves Eswatini [23] Ear infections Leaves Uganda [15,24,25] Evil eye Roots mixed with those of Capparis tomentosa Lam., Carissa spinarum L., Croton macrostachyus Hochst. ex Delile and Pterolobium stellatum (Forssk.)…”

Section: Introductionmentioning

confidence: 99%

“…ex Delile and Pterolobium stellatum (Forssk.) Brenan Ethiopia [13] Eye problems Leaves and roots Kenya [24] Fever and febrile complaints Leaves South Africa and Tanzania [18,21,25,[27][28][29][30] Gall-bladder problems Leaves South Africa [20,21,31] Gangrene Roots Ethiopia [13] Gastritis Roots Mali [10][11][12]18,19,[32][33][34][35][36][37][38][39][40] Gastro-intestinal problems (appetizer, diarrhoea, digestive problems, indigestion and stomach problems) Flowers, leaves and roots Eswatini, Nigeria, South Africa, Tanzania, Uganda and Zimbabwe [15,18,20,21,[23][24][25]31,41,61,68] Snake and scorpion bites Leaves and roots Ethiopia [13,18,22,69,70] Ulcers Roots Cameroon and Mali [10][11][12]…”

Section: Introductionmentioning

confidence: 99%

Review of Pharmacological Properties, Phytochemistry and Medicinal Uses of Baccharoides adoensis

Maroyi

2020

J. Pharm. Nutr. Sci.

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Baccharoides adoensis is a shrub widely used as traditional medicine throughout its distributional range in tropical Africa. This study is aimed at providing a critical review of the pharmacological properties, phytochemistry, and medicinal uses of B. adoensis. Documented information on the pharmacological properties, phytochemistry, and medicinal uses of B. adoensis was collected from several online sources which included Scopus, Google Scholar, PubMed and Science Direct. Additional information on the pharmacological properties, phytochemistry, and medicinal uses of B. adoensis was gathered from pre-electronic sources such as book chapters, books, journal articles, and scientific publications sourced from the university library. The articles published between 1962 and 2020 were used in this study. This study showed that the roots, flowers, stems, and leaves of B adoensis are widely used as ethnoveterinary medicine and traditional medicines for backbone pain, reproductive problems, kidney diseases, fever and febrile complaints, wounds, ulcers, sexually transmitted infections, skin complaints, malaria, gastro-intestinal problems and respiratory problems. Phytochemical compounds identified from the species include alkaloids, carbohydrates, chondrillasterol, flavonoids, free sugars, glaucolides, glycosides, phenols, proanthocyanidin, saponins, steroids, tannins and terpenoids. Pharmacological research revealed that B. adoensis extracts and compounds isolated from the species have antimicrobial, antimycobacterial, anti-inflammatory, antioxidant, antiplasmodial, anti-pyretic, antitrypanosomal, antileishmanial, anti-ulcer and gastroprotective, immunomodulating, inhibition of Helicobacter pylori adhesion, larvicidal, cytotoxicity and toxicity activities. Baccharoides adoensis should be subjected to detailed phytochemical, pharmacological, and toxicological evaluations aimed at correlating its medicinal uses with its phytochemistry and pharmacological activities.

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In vitro antiplasmodial, antitrypanosomal and antileishmanial activities of selected medicinal plants from Ugandan flora: Refocusing into multi-component potentials

Cited by 25 publications

References 78 publications

Exploring Antimalarial Herbal Plants across Communities in Uganda Based on Electronic Data

Exploring Antimalarial Herbal Plants across Communities in Uganda Based on Electronic Data

Antiprotozoal dimeric naphthylisoquinolines, mbandakamines B₃ and B₄, and related 5,8′-coupled monomeric alkaloids, ikelacongolines A–D, from a Congolese Ancistrocladus liana

Review of Pharmacological Properties, Phytochemistry and Medicinal Uses of Baccharoides adoensis

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In vitro antiplasmodial, antitrypanosomal and antileishmanial activities of selected medicinal plants from Ugandan flora: Refocusing into multi-component potentials

Cited by 25 publications

References 78 publications

Exploring Antimalarial Herbal Plants across Communities in Uganda Based on Electronic Data

Exploring Antimalarial Herbal Plants across Communities in Uganda Based on Electronic Data

Antiprotozoal dimeric naphthylisoquinolines, mbandakamines B3 and B4, and related 5,8′-coupled monomeric alkaloids, ikelacongolines A–D, from a Congolese Ancistrocladus liana

Review of Pharmacological Properties, Phytochemistry and Medicinal Uses of Baccharoides adoensis

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Antiprotozoal dimeric naphthylisoquinolines, mbandakamines B₃ and B₄, and related 5,8′-coupled monomeric alkaloids, ikelacongolines A–D, from a Congolese Ancistrocladus liana