In vitro antiplasmodial activity of selected Luo and Kuria medicinal plants

Owuor, Bethwell O.; Ochanda, James O.; Kokwaro, J.O.; Cheruiyot, Agnes C.; Yeda, Redemptah; Okudo, Charles; Akala, Hoseah M.

doi:10.1016/j.jep.2012.09.045

Cited by 38 publications

(26 citation statements)

References 16 publications

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“…These plants were administered orally in the form of concoctions, mostly in combination with other plants. The infusion of the roots, stem bark and fruits, of one of the active plants, Carissa spinarum were administered orally to the livestock, in combination with decoction of other plants such as Albizia coriaria (Johns et al, 1990, Owuor et al, 2012). The juice from the berries of Solanum aculeastrum, which showed interesting antimicrobial activities, was usually instilled into the cattle, goat or sheep's nostrils (Owuor et al, 2012).…”

Section: Resultsmentioning

confidence: 99%

“…An approach for the development of novel antimicrobials is the use of ethno-botanical information in order to characterize plant substances for their antimicrobial activity. Traditional medicine based on medicinal plants in Africa is not only used in the primary health care system for people living mainly in rural areas in developing countries (Njoroge et al, 2010, Owuor et al, 2012), but also to manage a wide variety of livestock diseases (Githiori et al, 2005; Ole-Miaron, 2003). …”

Section: Introductionmentioning

confidence: 99%

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Selected ethno-medicinal plants from Kenya with in vitro activity against major African livestock pathogens belonging to the “ Mycoplasma mycoides cluster”

Kama-Kama

Midiwo

Ngángá

et al. 2016

Journal of Ethnopharmacology

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Ethnopharmocological relevanceMembers of ‘Mycoplasma mycoides cluster’ are important ruminant pathogens in Africa. Diseases caused by these Mycoplasma negatively affect the agricultural sector especially in developing countries through losses in livestock productivity, mortality and international trade restrictions. There is therefore urgent need to develop antimicrobials from alternative sources such as medicinal plants to curb these diseases. In Kenya, smallholder farmers belonging to the Maasai, Kuria and Luo rely on traditional Kenyan herbals to treat respiratory symptoms in ruminants. In the current study extracts from some of these plants were tested against the growth of members of Mycoplasma mycoides cluster.AimThis study aimed at identifying plants that exhibit antimycoplasmal activities using an ethnobotanical approach.Materials and methodsKenyan farmers of Maasai, Luo and Kuria ethnic groups were interviewed for plant remedies given to livestock with respiratory syndromes. The plant materials were thereafter collected and crude extracts prepared using a mixture of 50% of methanol (MeOH) in dichloromethane (CH2Cl2), neat methanol (MeOH), ethanol (EtOH) and water to yield four crude extracts per plant part. The extracts were tested in vitro against five strains of Mycoplasma mycoides subsp. capri, five strains of Mycoplasma mycoides subsp. mycoides and one strain of Mycoplasma capricolum subsp capricolum using broth micro-dilution assays with an initial concentration of 1 mg/ml. Minimum inhibitory concentration (MIC) of the most active extracts were determined by serial dilution.ResultsExtracts from five plants namely: Solanum aculeastrum, Albizia coriaria, Ekebergia capensis, Piliostigma thonningii and Euclea divinorum exhibited the highest activities against the Mycoplasma strains tested. Mycoplasma mycoides subsp. mycoides were more susceptible to these extracts than Mycoplasma mycoides subsp. capri and Mycoplasma capricolum susp. capricolum. The activities of the crude extracts varied with the solvent used for extraction. The MICs mean values of the active extracts varied from 0.02 to 0.6 mg/ml.ConclusionsThe results suggested that these plants could potentially contain antimicrobial compounds that might be useful for the treatment of respiratory diseases in ruminants. Future work should focus on the isolation and identification of the active compounds from the plant extracts that showed interesting activities and evaluation of their antimicrobial and cytotoxic potential.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Selected ethno-medicinal plants from Kenya with in vitro activity against major African livestock pathogens belonging to the “ Mycoplasma mycoides cluster”

Kama-Kama

Midiwo

Ngángá

et al. 2016

Journal of Ethnopharmacology

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“…Levantamentos realizados no estado de Rondônia feitos por Santos, Lima e Oliveira (2014) O P. barbatus vem sendo estudado amplamente em relação a sua atividade antibacteriana e anti-inflamatória (MATU; STADEN, 2003), além disso, estudos com atividade antiplasmódica in vitro relataram a ineficiência, segundo Owuor et al (2012), dado este que demonstra preocupação, pois esta planta foi a mais citada neste estudo para o tratamento desta patologia; sete estudos ao longo de 2005-2016 foram publicados.…”

Section: Discussionunclassified

Avaliação Etnobotânica De Plantas Utilizadas Como Potenciais Antimaláricos Na Região Da Amazônia Ocidental Brasileira

Martinez¹,

Pansini²,

Santos³

et al. 2018

ICSA

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RESUMOO planejamento satisfatório de novos alvos contra os estágios do parasito da malária esbarra nas lacunas sobre o conhecimento de plantas com potencial terapêutico, associadas à desvalorização das informações empíricas e à dispersão destas plantas medicinais arquivadas na memória da população usuária. No presente estudo, foi realizada uma avaliação etnobotânica de plantas com potencial medicinal utilizadas pelos pacientes com a infecção. Os participantes eram residentes de duas localidades da Amazônia ocidental, Porto Velho e Triunfo, entre as regiões urbana e rural. Foram entrevistadas 62 pessoas tidas como informantes, dos quais 62,9% afirmaram que utilizam a terapia natural com potencial medicinal. Foram relatadas 12 plantas pertencentes a 10 famílias: Asteraceae (2 etnoespécies), Rubiaceae (2 etnoespécies), Arecaceae, Lamiacea, Solanaceae, Fabaceae, Cucurbiaceae, Caprifoliaceae, Euphorbiaceae com 1 etnoespécie cada; as espécies mais citadas foram o Plectranthus barbatus Andrews (Boldo) e o Bidens pilosa L. (Picão), sendo as folhas as partes mais utilizadas.

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“…It is useful in cough, bronchitis, catarrh, foul ulcers and wounds, anorexia and vitiated conditions of vata [8,11]. Besides, the dichloromethane extract of leaves and twigs has been reported to be more active on chloroquine sensitive than resistant Plasmodium falciparum strains exhibiting promising antiplasmodial activity proving the claims of Luo and Kurio ethnic groups of Kenya [29]. Aqueous extract of leaves exhibited wound healing activity such as increase in granuloma breaking strength, wound contraction and decrease in epithelization period in different wound models in rats such as excision, incision and dead space wounds [30].…”

Section: Economic Potentialmentioning

confidence: 99%

Ocimum kilimandscharicum Guerke (Lamiaceae): A New Distributional Record for Peninsular India with Focus on its Economic Potential

Misra

Das

2015

Proc. Natl. Acad. Sci., India, Sect. B Biol. Sci.

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Ocimum kilimandscharicum Guerke (Lamiaceae), alien to the Indian flora, was discovered in the natural habitat from two locations of different agro-ecological zones of Odisha. After critical review of published literature on distribution, it was earlier known only from Uttarakhand. However, its natural occurrence in Odisha was found to be a new record for peninsular India. A detailed diagnostic description, photographs, ecology and potentiality of the species was provided for easy identification and further economic utilization.

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In vitro antiplasmodial activity of selected Luo and Kuria medicinal plants

Cited by 38 publications

References 16 publications

Selected ethno-medicinal plants from Kenya with in vitro activity against major African livestock pathogens belonging to the “ Mycoplasma mycoides cluster”

Selected ethno-medicinal plants from Kenya with in vitro activity against major African livestock pathogens belonging to the “ Mycoplasma mycoides cluster”

Avaliação Etnobotânica De Plantas Utilizadas Como Potenciais Antimaláricos Na Região Da Amazônia Ocidental Brasileira

Ocimum kilimandscharicum Guerke (Lamiaceae): A New Distributional Record for Peninsular India with Focus on its Economic Potential

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