In vitro antiplasmodial activity and cytotoxicity of 33 West African plants used for treatment of malaria

Zirihi, Guédé Noël; Mambu, Lengo; Guédé-Guina, F.; Bodo, Bernard; Grellier, Philippe

doi:10.1016/j.jep.2005.01.004

Cited by 246 publications

(160 citation statements)

References 20 publications

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“…Strychnos icaja and the cytotoxicity of Physalis angulata extract were previously described and showed, in this last case, a SI between 4 and 5 (Frederich et al, 2000;Frederich et al, 2001;Zirihi et al, 2005). Anisopappus chinensis showed the higher SI for its methanolic and dichloromethane extracts, with values superior to 10.…”

Section: Resultssupporting

confidence: 52%

“…Physalis angulata showed the stronger activity (with S. icaja) against the two strains of Plasmodium falciparum (< 5µg/ml for all extracts), a SI between 4 and 5, and its aqueous extract was also active in vivo. The in vitro antimalarial activity and the cytotxicity of this plant were previously reported (Hsieh et al, 2006;Kvist et al, 2006;Zirihi et al, 2005) but we obtained a better activity in the present study. The plant is also part of a four-plants decoction used in Ghana to treat malaria and active on rats (Ankrah et al, 2003).…”

Section: Melia Azedarach L (Meliaceae)supporting

confidence: 55%

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In vitro and in vivo antimalarial and cytotoxic activity of five plants used in congolese traditional medicine

Lusakibanza

Mesia

Tona

et al. 2010

Journal of Ethnopharmacology

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Aim of the studyThe in vitro antiplasmodial activity and cytotoxicity of methanolic and dichloromethane extracts from five Congolese plants were evaluated. The plants were selected following an ethnobotanical survey conducted in D.R. Congo and focusing on plants used traditionally to treat malaria. The in vivo antimalarial activity of aqueous and methanolic extracts active in vitro was also determined in mice infected by Plasmodium berghei berghei. Materials and methodsThe growth inhibition of Plasmodium falciparum strains was evaluated using the measurement of lactate dehydrogenase activity. The extracts (aqueous, CH 3 OH, EtOH and CH 2 Cl 2 ) were prepared by maceration and tested in vitro against the 3D7 (chloroquine sensitive) and W2 (chloroquine resistant) strains of Plasmodium falciparum and against the human normal fetal lung fibroblasts WI-38 to determine the selectivity index. Some extracts were also used at the dose of 300mg/kg to evaluate their activity in mice infected since 4 days by Plasmodium berghei. ResultsTwo plants presented a very high activity (IC 50 < 3µg/ml). These plants were Strychnos icaja roots bark (MeOH and CH 2 Cl 2 ) and Physalis angulata leaves (MeOH and CH 2 Cl 2 ). One plant (Anisopappus chinensis whole plant, MeOH and CH 2 Cl 2 ) presented a high activity (IC50 < 15µg/ml).The extracts of Anisopappus chinensis and Physalis angulata showed also a good inhibition of parasitemia in vivo. Flavonoids, phenolic acids and terpenes were identified in these plants by a general phytochemical screening method. ConclusionThree plants showed a very interesting antiplasmodial activity (Anisopappus chinensis, Physalis angulata, Strychnos icaja) and one of them showed a good selectivity index ( >10, Anisopappus chinensis). Anisopappus chinensis and Physalis angulata were also active in vivo.

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Section: Resultssupporting

confidence: 52%

Section: Melia Azedarach L (Meliaceae)supporting

confidence: 55%

In vitro and in vivo antimalarial and cytotoxic activity of five plants used in congolese traditional medicine

Lusakibanza

Mesia

Tona

et al. 2010

Journal of Ethnopharmacology

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“…Morinda morindoïdes (Baker) Milne-Redhead (Rubiaceae) is well known in traditional medicine practice in some African countries (Nigeria, Democratic Republic of Congo and Congo-Brazzaville) where its leaves are frequently used for treating malaria, diarrhoea, amoebiasis, haemorrhoids, gonorrheoa and rheumatic pains [1][2][3][4]. In Ivory Coast, the leaf of the plant is traditionally used by people in the west central region against diarrhoea [4].…”

Section: Introductionmentioning

confidence: 99%

A Study of the Hepatic Tolerance of the Ethyl Acetate Fraction of <i>Morinda morindoides</i> (Baker) <i>Milne- Redhead</i> (Rubiaceae) Extract in Rabbit

BI¹,

Djyh²,

Calixte³

et al. 2011

Trop. J. Pharm Res

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“…Its high IC 50 values against normal vero and macrophage cell lines indicate that it is a safe anticancer medicinal plant and is selectively inhibitory on cancer cells. According to Zirich et al [26] plants with IC 50 ≥ 20 µg/ ml are recognized as safe. Inhibitory selectivity of medicinal plants with antiproliferative activity has been also demonstrated in previous studies.…”

Section: Discussionmentioning

confidence: 99%

In Vitro Antiproliferative Activity of Aqueous Root Bark Extract of Cassia abbreviata (Holmes) Brenan

SM¹,

RC²

2016

J Cancer Sci Ther

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Cancer is referred to as uncontrolled abnormal proliferation of body cells. Currently cancer treatment and management is a challenge due to complexity of the disease, toxicity of chemotherapy, unaffordability of treatment and severe side effects. Therefore, it is imperative to investigate complementary and alternative medicine for leads and development of anticancer drugs. Cassia abbreviate (C. abbreviata) has been traditionally used for its ethnotherapeutic properties and pharmacological activities. It has been reported to possess antiproliferative activity, though there is no scientific evidence to validate this claim. The main objective of this study was to determine the antiproliferative activity of aqueous root bark extract of C. abbreviata on hepatocellular carcinoma (HCC), vero, and macrophage cell lines in vitro. The antiproliferative activity of aqueous root bark extract of C. abbreviata was determined using MTT assay. The results showed that aqueous root bark extract of C. abbreviata has antiproliferative activity against HCC, vero and macrophage cell lines. The extract had the highest antiproliferative activity against HCC cell line with an IC 50 of 1.49 µg/ml as compared to 81.08 µg/ml and 128.38 µg/ml in macrophages and vero cells respectively. The IC 50 observed on non-cancerous normal cells (macrophages and vero cells) indicated that the plant extract had little antiproliferative effects on normal cells hence regarded as safe. The extract contained flavonoids, phenols, tannins and saponins. In conclusion the antiproliferative activity of aqueous root bark extract of Cassia abbreviata observed could be attributed to the phytochemicals present in this plant extract. The results of this study, validates the claim that aqueous root bark extract of C. abbreviata has antiproliferative activity and justifies its use in herbal medicine.

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In vitro antiplasmodial activity and cytotoxicity of 33 West African plants used for treatment of malaria

Cited by 246 publications

References 20 publications

In vitro and in vivo antimalarial and cytotoxic activity of five plants used in congolese traditional medicine

In vitro and in vivo antimalarial and cytotoxic activity of five plants used in congolese traditional medicine

A Study of the Hepatic Tolerance of the Ethyl Acetate Fraction of <i>Morinda morindoides</i> (Baker) <i>Milne- Redhead</i> (Rubiaceae) Extract in Rabbit

In Vitro Antiproliferative Activity of Aqueous Root Bark Extract of Cassia abbreviata (Holmes) Brenan

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