In vitro antiplasmodial activity and cytotoxicity of extracts and chromatographic fractions of twigs from Pappea capensis EckI & Zeyh. (Sapindaceae)

Pappea capensis Eckl. & Zeyh. (Sapindaceae): Evaluation of traditional and future potential uses

“…Mabuza et al ( 2022) evaluated the antiplasmodial activities of dichloromethane, methanol and water mixture of P. capensis twigs using the using the [ 3 H]-hypoxanthine incorporation assay against the Plasmodium falciparum (NF54) and chloroquine as the standard drug. The extract exhibited activities with the best IC50 value of 2.59 μg/ml in comparison of 0.0035 μg/ml exhibited by the positive control (Mabuza et al 2022).…”

“…angustifolia F.White (Ebenaceae) and Grewia hexamita Burret (Malvaceae) as traditional medicines against infertility and menstrual problems (Chauke et al 2015, Maroyi 2017. Watt & Breyer-Brandwijk 1962, Gelfand et al 1985, Mabogo 1990, Mulaudzi et al 2011, Muthee et al 2011, Makule et al 2014, Makule 2015, Tshikalange et al 2016, Pendota et al 2017 Gelfand et al 1985, Mabogo 1990, Palgrave, 2002, Hankey 2004, Mulaudzi et al 2011, Pendota et al 2017 Watt & Breyer-Brandwijk 1962, Harjula 1980, Hutchings et al 1996, Kiringe 2006, Kokwaro 2009, Semenya & Maroyi 2012, Chauke et al 2015, Kimondo et al 2015, Makule 2015, Bigirimana et al 2016 Hutchings et al 1996, Hankey 2004, Karau et al 2012a,b, Semenya & Maroyi 2019a, b, c, 2020, Nicosia et al 2022 Rheumatism (arthritis and joint pains) Bark, fruits, leaves, roots and stem bark Eritrea, Kenya and Tanzania Kiringe 2006, Wambugu et al 2011, Kipkore et al 2014…”

“…The fruits of P. capensis are regarded as pleasant-tasting and widely used as a fruit snack in tropical Africa (Palmer & Pitman 1972, Schmidt et al 2017, Van Wyk & Gericke 2018. In South Africa, the sap of P. capensis fruits are collected and ground into jam, jelly, vinegar or allowed to ferment into a fairly potent alcohol and wine (Mabogo 1990, Van Wyk & Gericke 2018. The bark, leaves, seeds and stems of P. capensis are sold in informal herbal medicine markets in in Kajiado, Narok and Nairobi counties in Kenya as sources of traditional medicines (Mwaura et al 2020).…”