In vitro antiplaque activity of octenidine dihydrochloride (WIN 41464-2) against preformed plaques of selected oral plaque-forming microorganisms

Slee, Andrew M.; O'Connor, J R

doi:10.1128/aac.23.3.379

Cited by 46 publications

(34 citation statements)

References 25 publications

(37 reference statements)

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“…In earlier studies, the MICs of OCT and CHG against a variety of test bacteria were quite similar (2,20). In this study, the bactericidal activity of OCT was superior to that of CHG, especially against Staphylococcus aureus and Streptococcus pyogenes.…”

Section: Resultsmentioning

confidence: 65%

“…Earlier studies demonstrated its activity against dental plaque microflora (16,20,21); this study shows that OCT is also effective against skin microflora.…”

Section: Resultsmentioning

confidence: 93%

“…Previous studies with this compound have shown it to be effective in inhibiting the growth of plaqueforming bacteria (16,20,21) and in reducing development of plaque in both experimental animals (6,16) and humans (13). The purpose of this study was to determine the degerming capacity of OCT on skin and to estimate its potential as a skin antiseptic by examining its microbicidal activity against common nosocomial pathogens which might be encountered as transient skin microbes.…”

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confidence: 99%

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Microbicidal activity of octenidine hydrochloride, a new alkanediylbis[pyridine] germicidal agent

Sedlock¹,

Bailey²

1985

Antimicrob Agents Chemother

101

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The potential of octenidine hydrochloride (WIN 41464-2) as a topical microbicide was measured both by in vitro death kinetics and reductions in numbers of bacteria on the skin of cynomolgus monkeys. Semilogarithmic survial curves were plotted to measure the microbicidal activity of various concentrations of octenidine against Staphylococcus aureus. The microbicidal activity of octenidine was also determined for Staphylococcus epidermidis, Proteus mirabilis, Streptococcus pyogenes, Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa, Serratia marcescens, and Candida albicans. Death rates for the same microbial strains were compared with those obtained by using chlorhexidine gluconate. Octenidine concentrations of <1.5 ,LM (0.94 ,ug/ml) caused a greater than 99% reduction of each microbial population within 15 min. Staphylococcus epidermidis was the most susceptible of the test organisms, and E. coli and C. albicans were the least susceptible. Octenidine was more active than chlorhexidine against each test strain. Skin-degerming activities of aqueous and formulated octenidine and formulated chlorhexidine were compared in single and multiple applications of these agents to the hand and foot surfaces of monkeys by using a glove-juice extraction procedure to measure the skin microflora. Aqueous octenidine, at a concentration of 0.2 to 1.6% reduced resident microflora populations from 90 to 99.98%, depending on the concentration and number of applications. Octenidine formulated at 2% in a surfactant-based vehicle exhibited significantly better skin-degerming activity than did either a nonmedicated vehicle or the Hibiclens brand of 4% chlorhexidine gluconate.

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Section: Resultsmentioning

confidence: 65%

“…Earlier studies demonstrated its activity against dental plaque microflora (16,20,21); this study shows that OCT is also effective against skin microflora.…”

Section: Resultsmentioning

confidence: 93%

mentioning

confidence: 99%

See 1 more Smart Citation

Microbicidal activity of octenidine hydrochloride, a new alkanediylbis[pyridine] germicidal agent

Sedlock¹,

Bailey²

1985

Antimicrob Agents Chemother

101

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“…7,11 Octenisept was demonstrated to have broad-spectrum antimicrobial effects against both Gram-positive and Gramnegative bacteria, fungi and several viral species, 14 and the efficacy of octenidine was reported against dental plaqueassociated bacteria when compared with CHX. 25,26 Octenisept was chosen as a test solution in this study after the publication of reports that it was used as a root canal dressing material and had antibacterial activity against E. faecalis in root canal and dentine after one minute. 13 There are a few studies that evaluate the residual antimicrobial activity of the immersion of gutta-percha into different solutions.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Residual Antimicrobial Effects and Surface Changes of Gutta-Percha disinfected with Different Solutions

Şahinkesen¹,

Oktay²,

Er³

et al. 2011

The Journal of Contemporary Dental Practice

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Aim:To determine the possible residual antibacterial effects and possible surface changes caused by 5.25% NaOCl, 2.5% NaOCl, 2% CHX and 0.05% Octenisept on in vitro gutta-percha points after different disinfection protocols. Materials and methods:A total of 121 standard # 40, 0.2% gutta-percha cones were cut 10 mm from the tip, sterilized with ethylene oxide. The samples were divided into five groups, and each group was divided into three subgroups according to immersion periods of gutta-percha cones into solutions. One gutta-percha cone from each group was selected for SEM evaluation.Results: All of the tested solutions were effective on the selected microorganisms when compared with the control solution. No surface alterations were detected on the gutta-percha cones. Conclusion:In the limits of this study, immersion of gutta-percha into 2% CHX for one minute was found the most effective method to eliminate the selected microorganisms.Clinical significance: Although gutta-percha points are aseptic in their package, once opened and used, gutta-percha cones may be contaminated. In order to eliminate bacteria and not to cause surface changes on gutta-percha cones, disinfection solution must be selected carefully.

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“…8 Octenidine hydrochloride (OCT) Octenidine (Schulke & Mayr GmbH, Norderstedt, Germany), is a bispyridine derivative, i.e., N,N-[1,10-decanediyldi-1(4H)-pyridinyl -4 pylidene] bis (1-octanamine) dihydrochloride a new bipyridine antimicrobial compound, has been developed as a potential antimicrobial/antiplaque agent for use in mouthwash formulations. 9 The existing data suggest that a mouthrinse containing 0.1% OCT may be capable of exerting beneficial clinical effects upon plaque accumulation and gingivitis. OCT used in the form of mouthrinse was reported to inhibit dental plaque and caries both in rats and humans.…”

mentioning

confidence: 99%

Untitled

2016

IJPSR

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ABSTRACT:To evaluate the antimicrobial activity of Octenidine (OCT) 0.1%, Chlorhexidine (CHX) 0.2% against bacterial strains of Enterococcus faecalis and Staphylococcus aureus. The strains were inoculated in 7ml of brain heart infusion broth and diluted to reach the concentration equivalent (0.5 McFarland standard). 1ml of organism suspension was contacted with 1ml of each mouthwash and was removed at time interval of 3,5 and 10 minute and plated on Brain Heart Infusion agar. After 72 hours of incubation, colony counts were measured using stereomicroscope. Kruskal Wallis test was conducted on mean number of CFU. Post-hoc tests were conducted by using the Mann Whitney U test and Duncan's-test of multiple comparisons. The results showed that OCT 0.1% was found to be the most effective in substantially reducing total bacterial counts after 3, 5 and 10 min time interval. OCT 0.1% was found to be the most effective in substantially reducing total bacterial counts.

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In vitro antiplaque activity of octenidine dihydrochloride (WIN 41464-2) against preformed plaques of selected oral plaque-forming microorganisms

Abstract: The antibacterial activity of octenidine dihydrochloride (WIN 41464-2)

Cited by 46 publications

References 25 publications

Microbicidal activity of octenidine hydrochloride, a new alkanediylbis[pyridine] germicidal agent

Microbicidal activity of octenidine hydrochloride, a new alkanediylbis[pyridine] germicidal agent

Evaluation of Residual Antimicrobial Effects and Surface Changes of Gutta-Percha disinfected with Different Solutions

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