2016
DOI: 10.1371/journal.pone.0165575
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In Vitro Antioxidant versus Metal Ion Chelating Properties of Flavonoids: A Structure-Activity Investigation

Abstract: Natural flavonoids such as quercetin, (+)catechin and rutin as well as four methoxylated derivatives of quercetin used as models were investigated to elucidate their impact on the oxidant and antioxidant status of human red blood cells (RBCs). The impact of these compounds against metal toxicity was studied as well as their antiradical activities with DPPH assay. Antihemolytic experiments were conducted on quercetin, (+)catechin and rutin with excess of Fe, Cu and Zn (400 μM), and the oxidant (malondialdehyde,… Show more

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Cited by 215 publications
(165 citation statements)
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References 87 publications
(89 reference statements)
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“…Previously, several studies reported that the catechol moiety played a critical role in phenolic antioxidants . However, Woodman insisted on a minor role of the catechol moiety .…”
Section: Resultsmentioning
confidence: 99%
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“…Previously, several studies reported that the catechol moiety played a critical role in phenolic antioxidants . However, Woodman insisted on a minor role of the catechol moiety .…”
Section: Resultsmentioning
confidence: 99%
“…Moreover, all subtypes are composed of a dihedral angle between the B ring and the A/C fused rings. Thus, it is difficult to predict the ET (or antioxidant) potential of flavonoids, regardless of the amount of antioxidant structure–activity relationship studies …”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…These pathways can also be found in the DPPH•‐scavenging reaction . In fact, the DPPH•‐scavenging assay has been successfully used to systematically evaluate the antioxidant capacities of flavonoids and anthocyanidins ,,…”
Section: Figurementioning
confidence: 99%
“…Prooxidant activity is thought to be directly proportional to the total number of hydroxyl groups [25], especially in the B-ring [26], and the concentration of the flavonoid [27].…”
Section: +mentioning
confidence: 99%