In-vitro antioxidant, the antimicrobial and anticarcinogenic activity of environment friendly nano formulation using Mangifera indica

Abstract

The green synthesis of nanoparticles (NPs) from plant extracts is an innovative and considered as an effective method, which has many biological and therapeutic benefits. In this regard, silver nanoparticles were synthesized from leaves of Mangifera indica (Mango) and their properties were characterized. Morphological characterizations such as UV-Visible Spectroscopy (UV-Vis), Fourier-Transform Infra-red Spectroscopy (FTIR), and X-ray diffraction (XRD) confirm the physical characteristics of silver nano-particles. In addition, Mangifera indica phytochemicals possesses DPPH radical scavenging activity, antioxidant, and antibacterial properties. The nano formulation (phytochemicals + NPs) is also tested against the Hep G2 human cell line for anticarcinogenic properties. Nano formulation concentrations at 300μg/ml shown anticarcinogenic effect to Hep G2 human cell lines up to 53.29768%. The Bio pesticidal activity of the paddy pest Cicadella viridis (green leaf hopper) was checked through an antifeedant assay and the activity of the pest was decreased with the introduction of nano formulation. These results show better antioxidant, antibacterial and anticarcinogenic properties. Thus, they can be used to replace chemical therapeutic drugs.