In Vitro Antioxidant Properties of Dichloromethanolic Leaf Extract of Gnidia glauca (Fresen) as a Promising Antiobesity Drug

Abstract

The acquisition of ethnobotanical information from traditional practitioners remains an empirical aspect of understanding the ethnopharmacology research. However, integration of information on chemical composition of plant extracts and their pharmacological activities forms a key resource for synthesis of new and effective therapeutics. In traditional African medicine, Gnidia glauca has folkloric remedies against obesity and its associated oxidative stress-mediated complications. However, the upsurge in its use has not been accompanied with scientific validations to support these claims. The present study aimed to determine the antioxidant potential of G glauca as a promising antiobesity agent. The antioxidant effects of the extract were assessed against 1,1-diphenyl-2-picrylhydrazyl, hydroxyl, hydrogen peroxide, nitric oxide, and superoxide radicals as well as lipid peroxidation, iron-chelating effect, and ferric-reducing power. Phytochemical analysis was conducted using gas chromatography linked to mass spectrophotometry. The results revealed that G glauca exhibited scavenging activities against all radicals formed. Besides, the extract showed iron chelation and ferric reducing abilities. The extract indicated a lower half maximal inhibitory concentration value than the standards used. For instance, the extract inhibited 50% of the formation of 2,2-diphenyl-1-picrylhydrazine at the concentration of 1.33 ± 0.03 mg/mL relative to 1.39 ± 0.06 mg/mL of the standard, vitamin C at 1% confidence limit. Similarly, the extract scavenged 50% of hydroxyl radical at 204.34 ± 10.64 μg/mL relative to 210.05 ± 8.80 μg/mL of gallic acid. The extract also contained various phytochemicals that have been associated with antiobesity effects. The synergistic effects of these phytocompounds increase their bioavailability and action on multiple molecular targets thereby correcting obesity-induced oxidative stress.

Antioxidant Properties and In-Vitro Radical Scavenging Activities of Tannin-Rich and Flavonoid-Rich Fraction of Annona senegelensis and Vernonia amygdalina leaves

“…Medicinal plants are significant source of efficient chemotherapeutics, which are critical for human health maintenance. In terms of mechanism of action, biological properties, and chemical structures, these phyto-compounds are special (Arika et al, 2019). Antioxidants counteract the effects of free radicals by either reacting with, neutralizing, or fighting for substrates with molecular oxygen (O2) as their terminal electron acceptor (Arika et al, 2019;Lallianrawna, 2013).…”

Protective Effect of Ipomoea biloba on Myocardial Antioxidant Status in Isoproterenol Induced Myocardial Infarction Male Albino Rats

“…The primary contrast is oxidative stress, which can result in diseases like acute myocardial infarction or cancer [5]. Among other disorders, oxidative stress is a major active factor in the onset and progression of cancer, diabetes mellitus, cardiovascular diseases, neurodegenerative diseases, and inflammatory diseases [6]. Hence this present investigation was aimed to investigate the Antioxidant activity against ethanolic leaf extract of Ipomoea biloba leaves against the ISO induced myocardial infarction in rats.…”

Determination of Bioactive Chemicals and Antioxidant Capacity in Different Plant Parts of Coriander (Coriandrum Sativum L.)

“…Now humans rely on plant either as sustenance source as restorative or as a medication source because of their ability to cope with free radicals. Plants contain antioxidant compounds among which phenols and flavonoids are of great importance because of their specialized structure by which they reduce free radical by donating hydrogen and extinguish singlet oxygen (Arika et al, 2019). The phenolic content of plant and antioxidative potential is correlated to each other (Aryal et al, 2019).…”