In vitro Antioxidant Potentials of Some Herbal Plants from Southern Nigeria

Nwaehujor, Chinaka O.; Ode, Julius O.; Akande, Motunrayo Ganiyat

doi:10.3923/jms.2013.56.61

Cited by 11 publications

(8 citation statements)

References 6 publications

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“…The following activities have been reported from B. micrantha : anthelmintic [ 79 ], antibacterial [ 19 , 32 , 36 , 74 , 80 , 81 , 82 , 83 ], anticonvulsant and sedative [ 84 ], antidiabetic [ 85 ], antidiarrhoeal [ 25 ], antifungial [ 36 , 83 ], anti- Helicobacter pylori [ 70 , 81 , 82 ], antimycobacterial [ 78 , 86 ], antinociceptive [ 87 ], antioxidant [ 77 , 85 , 87 , 88 , 89 ], antiplasmodial [ 59 , 90 , 91 ], antischistosomal [ 92 ], antiviral [ 39 , 40 ], hepatoprotective [ 88 ], insecticidal [ 93 ], β-lactamase inhibitory [ 94 ], toxicity and cytotoxicity [ 87 , 95 , 96 , 97 , 98 , 99 ].…”

Section: Pharmacological Properties Of B Micranthamentioning

confidence: 99%

“…The ferric reducing antioxidant power showed a significant concentration-dependent increase in the total antioxidant power. Nwaehujor et al [ 89 ] evaluated antioxidant activities of the methanolic leaf extracts of B. micrantha using the DPPH and FRAP assay methods with ascorbic acid as reference standard. The methanol extracts of B. micrantha leaves gave 98% antioxidant activity at a maximal test concentration of 400 µg/mL while ascorbic acid produced a comparatively reduced percentage value of 79% at the same concentration [ 89 ].…”

Section: Pharmacological Properties Of B Micranthamentioning

confidence: 99%

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Ethnopharmacology and Therapeutic Value of Bridelia micrantha (Hochst.) Baill. in Tropical Africa: A Comprehensive Review

Maroyi

2017

Molecules

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Bridelia micrantha is traditionally used in tropical Africa to treat a wide range of human and animal diseases. The aim of this study was to summarise the research that has been done on the ethnomedicinal uses, phytochemistry and pharmacological properties of B. micrantha so as to understand its importance and potential value in primary healthcare systems. The literature search for information on ethnomedicinal uses and pharmacological activities of B. micrantha was undertaken using databases such as Web of Science, Scopus, Google Scholar, Science Direct, BioMed Central (BMC), PubMed and Springerlink. Other relevant literature sources included books, book chapters, websites, theses, conference papers and other scientific publications. This study showed that B. micrantha is used as herbal medicine in just over half (57.3%) of the countries in tropical Africa where it is indigenous. A total of 54 ethnomedicinal uses of B. micrantha have been recorded with a high degree of consensus on burns, wounds, conjunctivitis, painful eyes, constipation, gastric ulcers, cough, headache, rheumatism, painful joints, dysentery, ethnoveterinary medicine, malaria, sexually transmitted infections, stomach ache, tape worms and diarrhoea. Different plant parts, aqueous and organic extracts exhibited anthelmintic, antimicrobial, anticonvulsant and sedative, antidiabetic, antidiarrhoeal, antinociceptive, antioxidant, antiplasmodial, antischistosomal, hepatoprotective, insecticidal and β-lactamase inhibitory activities.

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Section: Pharmacological Properties Of B Micranthamentioning

confidence: 99%

Section: Pharmacological Properties Of B Micranthamentioning

confidence: 99%

Ethnopharmacology and Therapeutic Value of Bridelia micrantha (Hochst.) Baill. in Tropical Africa: A Comprehensive Review

Maroyi

2017

Molecules

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“…Antioxidants are known to be intermediates between chemical reactions and biological activities. They do not completely get rid of free radicals in the body but retard or minimize the damage caused and also block processes of oxidation by neutralizing free radicals thereby becoming oxidized themselves (Nwaehujor et al, 2013). Endogenous antioxidants prevent oxidation by reducing the rate of chain initiation.…”

Section: Discussionmentioning

confidence: 99%

“…There is therefore need for novel antioxidants with better pharmacological potencies and medicinal plants readily provide sources for such novel drugs discovery (Fabricant and Farnsworths, 2001). The searches for plant-derived medication have accelerated in recent years as ethnopharmacologists, botanists, microbiologists, and natural products chemists are greatly involved in exploring the universe for phytochemicals and ""leads"" which could be developed for treatment of numerous diseases (Nwaehujor et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Phytochemical and in vitro antioxidant studies on methanol extract of Vernonia calvoana leaf and its polar fractions: Preliminary study

Chinaka¹,

Edwin²

2020

Afr. J. Cell. Path

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This study aims to screen possible antioxidant potentials of methanol extract and polar fractions of Vernonia calvoana leaves and its phytochemical constituents since the leaves are used ethno medically in managing ailments like wounds, blood pressure, inflammation, arthritis, and bone diseases. Dried leaves (900 g) were ground and de-fatted with n-hexane. The dry marc was extracted using 80% methanol and water. Filtrate was concentrated using rotary evaporator at 40°C. Acute toxicity study and phytochemical analysis were performed with crude extract. Fractionation of crude extract using gradient concentrations of methanol and distilled water yielded 4 fractions-F 1 , F 2 , F 3 and F 4. Fractions with the crude were used for in vitro antioxidant studies. From the results, crude extract showed no signs of toxicity in mice at 2000 mg/kg orally. Phytochemical screening showed presence of alkaloids, flavonoids, tannins, phenols, steroids, saponins, terpenes, arthroquinones, carbohydrates and glycosides. The highest percentage antioxidant activity observed with crude extract was 72.37 at 500 µg/ml in DPPH spectrophotometric assay. DPPH results showed percentage antioxidant activity of 81.4% at 500 µg/ml of F 1 and 67.73% at 500 µg/ml of F 2. The FRAP values of the crude extract, F 1 , F 2 , F 3 and F 4 at 500 µg/ml were 1.957, 2.234, 1.731, 1.245 and 1.025 µM respectively. These results showed that the activities of methanol extract of leaves of V. calvoana may be dependent on the concentration of the extracting solvent. Vernonia species are known to contain abundant saponins and flavonoids which are polar compounds and readily soluble in methanol. This may explain the above observed antioxidant activities and thus, the use of the leaves in different traditional curative therapies in Southern Nigeria.

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“…Furthermore [35]. But H. madagascariensis exhibited moderate activity [36] while A. precatorius [37] and B. micrantha [38] have demonstrated effective inhibitions ( Table 1) [39]. However, effective inhibitions were observed on root extracts of D. tripetala (IC 50 0.631 μgmL −1 ) and M. excelsa (IC 50 0.194 μgmL −1 ) compared to 4.60 μgmL −1 ascorbic acid [40].…”

Section: Antioxidant Activities Of Crude Extractsmentioning

confidence: 99%

Antioxidants from Nigerian Medicinal Plants: What Are the Evidence?

Aliyu¹,

Achika²,

Adewuyi³

et al. 2020

Lipid Peroxidation Research

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The search for natural antioxidants from plants would continue to be a dominant research interest for many years. This is because of the increasing understanding on the role of oxidative stress in damaging cell structures such as DNA, due to over production of free radicals and reactive oxygen species (ROS) in human systems, which are linked to inflammation, cancer and diabetes. However, phenolic compounds especially from phytochemicals or vegetable foods play important roles in reducing the risk of these diseases and reinforces the importance of natural antioxidants in human health. These antioxidant molecules neutralize or quench the ROS by either hydrogen atom transfer or single electron transfer mechanisms. Thus, the capacity to scavenge ROS and free radicals or inhibits lipid peroxidation is measured quantitatively as the strength of antioxidant activity. Several chemical and biochemical protocols have been used in the evaluation of plant extracts as antioxidants. Overwhelming literature reports have indicated varying degrees of antioxidant efficacies of extracts from Nigerian medicinal plants in comparison to synthetic antioxidants. These efficacies were analyzed to provide insight into the strength of antioxidant activity. This chapter reviewed 250 Nigerian medicinal plants in search of evidence for effective antioxidants.

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In vitro Antioxidant Potentials of Some Herbal Plants from Southern Nigeria

Cited by 11 publications

References 6 publications

Ethnopharmacology and Therapeutic Value of Bridelia micrantha (Hochst.) Baill. in Tropical Africa: A Comprehensive Review

Ethnopharmacology and Therapeutic Value of Bridelia micrantha (Hochst.) Baill. in Tropical Africa: A Comprehensive Review

Phytochemical and in vitro antioxidant studies on methanol extract of Vernonia calvoana leaf and its polar fractions: Preliminary study

Antioxidants from Nigerian Medicinal Plants: What Are the Evidence?

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