In Vitro Antioxidant Capacity of Crude Extracts and Acetogenin Fraction of Soursop Fruit Pulp

Ae, León-Fernández; Sg, Sáyago-Ayerdi; Rm, Velázquez-Estrada; Lg, Zepeda-Vallejo; Yahia, Elhadi M.; Montalvo‐González, Efigenia

doi:10.4172/2153-2435.1000550

Cited by 5 publications

(3 citation statements)

References 36 publications

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“…In contrast to peel and seeds, the highest SP values for columella (143.35 mg/g DM) and pulp (23.62 mg/g DM) were observed when the lowest values for the experimental conditions were applied (X ET = 10 min, X PC = 0.4 s, X SA = 40% and X ET = 5 min, X PC = 0.7 s, X SA = 40%, respectively). León-Fernández et al [22] reported an SP content of 35.6 mg/g (DM) in soursop pulp extract after applying extraction with an ultrasonic bath (3 h, 42 kHz at 25 °C) and using methanol as solvent. In this work, a 11-fold reduction in extraction time was achieved compared with the report of León-Fernández et al [22].…”

Section: Resultsmentioning

confidence: 99%

“…León-Fernández et al [22] reported an SP content of 35.6 mg/g (DM) in soursop pulp extract after applying extraction with an ultrasonic bath (3 h, 42 kHz at 25 °C) and using methanol as solvent. In this work, a 11-fold reduction in extraction time was achieved compared with the report of León-Fernández et al [22]. Several studies have shown that UAE could be used as an efficient method for the extraction of polyphenolic compounds from plant material [13,16].…”

Section: Resultsmentioning

confidence: 99%

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Optimization of Ultrasound-Assisted Extraction of Phenolic Compounds from Annona muricata By-Products and Pulp

et al. 2019

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Ultrasound-assisted extraction (UAE) is widely used; however, the efficiency of extraction depends on the raw materials. Therefore, optimization of UAE must be investigated for each type of plant material. By-products from soursop fruit have not been studied as a source of bioactive compounds. In this work, the optimization of UAE conditions (extraction time (5, 10, and 15 min), pulse cycle (0.4, 0.7, and 1 s), and sonication amplitude (40%, 70%, and 100%)) for the extraction of phenolic compounds (soluble, hydrolyzable, condensed tannins, and total polyphenols) from soursop by-products (seed, peel, and columella) and pulp was evaluated using response surface methodology. The optimal conditions for UAE to obtain the highest total polyphenol content from by-products and pulp was dependent on the raw material. Peel resulted in the highest content of total polyphenols (187.32 mg/g dry matter [DM]) followed by columella (164.14 mg/g DM), seed (36.15 mg/g DM), and pulp (33.24 mg/g DM). The yield of polyphenolic content from peel and columella obtained with UAE was higher (32–37%) than conventional extraction for 2 h under stirring (14–16%). The contents of gallic acid (0.36–15.86 µg/g DM), coumaric acid (0.07–1.37 µg/g DM), and chlorogenic acid (9.18–32.67 µg/g DM) in the different parts of the fruit were higher in the extracts obtained by UAE compared with a conventional extraction method (0.08–0.61, 0.05–0.08, 3.15–13.08 µg/g DM, respectively), although it was dependent on the raw materials. Soursop by-products can be functionally important if they are used to extract bioactive compounds by UAE; a technology with high potential for commercial extraction on a large scale.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Optimization of Ultrasound-Assisted Extraction of Phenolic Compounds from Annona muricata By-Products and Pulp

et al. 2019

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“…At 50-150 µg/mL, the activity of the standard was significantly (p=0.05) higher than that of all the fractions. In a study by Leon-Fernandez et al (2017), ethanol extract, chloroform fraction and isolated acetogenins were found to have high DPPH activity which was attributed to acetogenin concentration and phenolic compounds in the extract.…”

Section: The Dpph Radical Scavenging Activitymentioning

confidence: 98%

Antioxidant and anti-inflammatory potential, and chemical composition of fractions of ethanol extract of Annona muricata leaf

et al. 2020

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Serious health challenges have been associated with inflammation which is a major cause of mortality in the world. This study evaluated the antioxidant, anti-inflammatory potential, and chemical compositions of fractions of ethanol extract of Annona muricata leaf. The leaves were dried at room temperature, blended and extracted in sequential with solvents of varying degree of polarities, i.e., n-hexane, ethyl acetate and ethanol. Ethanol extract was fractionated via solvent-solvent partitioning into five fractions, i.e., n-hexane fraction (F1), dichloromethane fraction (F2), dichloromethane/ methanol (1:1) fraction (F3), methanol fraction (F4), and ethanol fraction (F5). These fractions were examined for their in-vitro antioxidant activities on DPPH, ABTS and H2O2 while the antiinflammatory activities were investigated using lipoxygenase inhibition, proteinase inhibition and membrane stabilization assays. The F4 being the most active fraction was further analyzed with GCMS to determine its chemical compositions. The results showed that F4 had the highest H2O2 scavenging activity at 10-100 µg/mL. The activity of F4 at 50 µg/mL was significantly higher (P<0.05) than that of other treatments including the standard (Vitamin C). Activity of F4 also showed significantly higher (P<0.05) membrane stabilization than other fractions at 50-100 µg/mL. F4 exhibited higher antioxidant and anti-inflammatory activities than the other fractions. The activity of this fraction could be attributed to the synergetic effect of various antioxidant compounds present in the fraction. Some of the bioactive compounds identified in the GC-MS of F4 were coumaran, tyrosol, phytol, tetracosanol, elaidic acid methyl ester and β-sitosterol.

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A New Series of Salicylic Acid Derivatives as Non-saccharide α-Glucosidase Inhibitors and Antioxidants

Jian-gang

Chen

et al. 2019

Biological & Pharmaceutical Bulletin

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In this study, a series of salicylic acid derivatives were designed and synthesized as novel non-saccharide α-glucosidase inhibitors. Biological evaluation indicated that when compared to acarbose, compounds T9, T10, and T32 exhibited a higher potency of α-glucosidase inhibitory activity with IC 50 values of 0.15 0.01, 0.086 0.01 and 0.32 0.02 mM, respectively. Evaluation of the inhibition kinetics indicated that T9, T10, T32, and acarbose interacted with α-glucosidase in a mixed non-competitive inhibitory manner. Moreover, T9, T10, and T32 statically quenched the fluorescence of α-glucosidase by formation of an inhibitor-αglucosidase complex. The docking results showed that hydrogen bonds were generated between the test compounds and α-glucosidase. The antioxidant study revealed that compound T10 exhibited a higher antioxidant activity via scavenging 1,1-diphenyl-2-picrylhydrazyl free radical (DPPH), thereby inhibiting lipid peroxidation and the total reduction capacity. In brief, the salicylic acid derivatives identified in this study were promising candidates for development as novel non-saccharide α-glucosidase inhibitors.

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In Vitro Antioxidant Capacity of Crude Extracts and Acetogenin Fraction of Soursop Fruit Pulp

Cited by 5 publications

References 36 publications

Optimization of Ultrasound-Assisted Extraction of Phenolic Compounds from Annona muricata By-Products and Pulp

Optimization of Ultrasound-Assisted Extraction of Phenolic Compounds from Annona muricata By-Products and Pulp

Antioxidant and anti-inflammatory potential, and chemical composition of fractions of ethanol extract of Annona muricata leaf

A New Series of Salicylic Acid Derivatives as Non-saccharide α-Glucosidase Inhibitors and Antioxidants

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