2014
DOI: 10.3390/molecules191118317
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In Vitro Antioxidant and Antiproliferative Activities of Methanolic Plant Part Extracts of Theobroma cacao

Abstract: Abstract:The aims of this study were to determine the antioxidant and antiproliferative activity of the following Theobroma cacao plant part methanolic extracts: leaf, bark, husk, fermented and unfermented shell, pith, root, and cherelle. Antioxidant activity was determined using 2,2-diphenyl-2-picrylhydrazyl (DPPH), thiobarbituric acid-reactive substances (TBARS), and Folin-Ciocalteu assays; the 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium (MTT) assay was used to determine antiproliferative activity. … Show more

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Cited by 77 publications
(61 citation statements)
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“…In this study, the EOs displayed the strongest antiproliferative activity was found to show moderate antioxidant activity (unpublished work) suggesting that antioxidant effects have moderate effects on the antiproliferative activity. This observation has been supported statistically by Baharum and his coworkers [21], who reported that the anti-cancer activities of Theobroma cacao plant extracts showed negative moderate correlation with their antioxidant activity. Stock solution of the EO was prepared by dissolving the EO in DMSO (final conc.…”
Section: Resultssupporting
confidence: 56%
“…In this study, the EOs displayed the strongest antiproliferative activity was found to show moderate antioxidant activity (unpublished work) suggesting that antioxidant effects have moderate effects on the antiproliferative activity. This observation has been supported statistically by Baharum and his coworkers [21], who reported that the anti-cancer activities of Theobroma cacao plant extracts showed negative moderate correlation with their antioxidant activity. Stock solution of the EO was prepared by dissolving the EO in DMSO (final conc.…”
Section: Resultssupporting
confidence: 56%
“…The cytotoxicity classification was sorting based on United State National Cancer Institute (USNCI) plant screening program. IC 50 value of extract that is between 20 and 100  μ g/mL is considered moderately cytotoxic [11, 22, 23] while less than 20  μ g/mL is considered strongly cytotoxic [23, 24]. …”
Section: Discussionmentioning
confidence: 99%
“…The percentage of cell viability (%) was calculated using the formula:T3Cell viability %=mean OD of treated cellmean OD of blankmean OD of untreated cellmean OD of blank×100The cytotoxic effects against 4T1 cells after 72 hours were recorded as IC 50 compared with untreated cells [10, 11]. The percentages of cell viability values against concentration of respective extracts were plotted in order to determine the IC 50 values of each extract.…”
Section: Methodsmentioning
confidence: 99%
“…Furthermore, saponin is a natural, low-priced and renewable glycoside that occurs naturally in different plants (over 100 families) and is expected to have potent antioxidant and anticancer activity. 36 For these reasons, the stability experiments in the present study focused on the lycopene microemulsions that were prepared using saponin under optimum operational conditions.…”
Section: Droplet Size and Pdimentioning
confidence: 99%