In vitro Antioxidant and Antibacterial activity of Bridelia atroviridis (Arasado)

Sokefun, Oluremilekun Olabisi; Eleyowo, Oluwole Olusoji; Avungbeto, Mary Oluwatoyin

doi:10.9734/jocamr/2017/29305

Cited by 2 publications

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“…This antioxidant capacity of the extract could be assigned to its ability to scavenge free radicals or to provide a H + proton or an electron to the oxidant molecules, preventing devastating effects of diabetes in treated groups [ 64 ]. Likewise, these antioxidant properties might also due to the presence of lycophene, β -carotene, phenolics, and flavonoids which are potent antioxidant species identified in the leaf of B. atroviridis [ 65 ]. In addition, corilagin, an amorphous tannin, detected in the plant extract possesses antioxidant activity [ 66 ].…”

Section: Discussionmentioning

confidence: 99%

Hydroethanolic Extract from Bridelia atroviridis Müll. Arg. Bark Improves Haematological and Biochemical Parameters in Nicotinamide‐/Streptozotocin‐Induced Diabetic Rats

Djouwoug

Ngueguim

Gounoue

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Bridelia atroviridis Müll. Arg. (B. atroviridis) is a plant used in Cameroonian traditional medicine to manage diabetes. The effects of hydroethanolic barks extract from B. atroviridis were evaluated on diabetes disorders including hematology, inflammatory, and oxidative stress parameters. The in vitro antioxidant capacity of the hydroethanolic bark extract (70 : 30) was evaluated. Nicotinamide-/streptozotocin-induced diabetic rats were daily treated with the B. atroviridis extract for fifteen days. Glycemia were evaluated every 5 days, insulin sensibility test was performed, and haematological, inflammatory, and oxidative stress parameters were analysed. Histomorphometry of the pancreas was realized. The extract was able to scavenge free radicals in vitro and decrease significantly the blood glucose levels. The treatment resulted in a significant alleviation of insulin resistance, anemia, leukocytopenia, and thrombocytopenia observed in untreated diabetic rats. The extract significantly decreased proinflammatory cytokines TNF-α, IL-1β, and IL-10. The rate of reduced glutathione was increased in the pancreas, whereas the catalase activity and nitrite concentration were decreased. Diabetic control showed a reduced size of Langerhans islet, whereas the size of islets was large in treated groups. The hydroethanolic extract of B. atroviridis was able to improve glycemia and alleviate haematological and inflammatory parameters disorders observed in diabetic conditions, probably due to its antidiabetic, anti-inflammatory, and antioxidant capacities.

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Section: Discussionmentioning

confidence: 99%

Hydroethanolic Extract from Bridelia atroviridis Müll. Arg. Bark Improves Haematological and Biochemical Parameters in Nicotinamide‐/Streptozotocin‐Induced Diabetic Rats

Djouwoug

Ngueguim

Gounoue

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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“…Similarly, alkaloids act as DNA intercalating agents that adversely affect DNA replication [48], while flavonoids and phenol deprive hydrogen bonding, protein, and some microbial enzymes metabolism resulting in inhibition of bacteria cell replication and cytosol metabolic activities [49]. Culminated synergistic antibacterial activities of these phytochemical compounds through different mechanisms would not be circumvented by resistant bacteria.…”

Section: Figure 4: Phylogenetic Diversity Of Nigerian Aloe Vera Variants With Repository a Vera Metadata Deposited In Genbank (Colored Blmentioning

confidence: 99%

Antibacterial kinetics and phylogenetic analysis of Aloe vera plants

Akinduti

Obafemi

Isibor

et al. 2021

Open Access Maced J Med Sci

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Uncontrolled use of antibiotics has resulted in the emergence of resistant bacteria. It has necessitated the evaluation of antibacterial activities and phylo-diversity of Aloe vera (also called Aloe barbadensis) plants as antimicrobial agent in Nigeria. Biotyped enteric bacilli of 251 strains obtained from fecal samples of patients with various gastro-intestinal complications are profiled for antibiogram. Resistant biotypes were assayed for susceptibility to Aloe vera latex and further evaluated for time-kill kinetics and phylo-diversity. More than 30% of enteric bacilli, including Citrobacter freundii, Escherichia coli and Proteus mirabilis were resistant to cotrimoxazole, ciprofloxacin, and tetracycline respectively at MIC >16 µg/ml (p=0.004). Aloe vera latex significantly inhibited 39.5% resistant enteric biotypes with a significant average reduction of the viable count at 1xMIC and 2xMIC to less than 3.0 Log10CFU/mL after 24 hours. Flavonoids, alkaloids, terpenoids and anthraquinine in anti-enteric sap significantly correlated and regressed with antibacterial activity (p<0.05), while two of the antimicrobial Aloe vera plants showed phylogenetic relatedness with other homologous. Anti-bacteria efficacy of some Nigerian Aloe vera latex could provide alternative therapy, while its phylo-diversity and genomic profiling would offer a promising avenue for identification and development of antimicrobial agents as drug candidates for natural antibiotics.

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In vitro Antioxidant and Antibacterial activity of Bridelia atroviridis (Arasado)

Cited by 2 publications

References 0 publications

Hydroethanolic Extract from Bridelia atroviridis Müll. Arg. Bark Improves Haematological and Biochemical Parameters in Nicotinamide‐/Streptozotocin‐Induced Diabetic Rats

Hydroethanolic Extract from Bridelia atroviridis Müll. Arg. Bark Improves Haematological and Biochemical Parameters in Nicotinamide‐/Streptozotocin‐Induced Diabetic Rats

Antibacterial kinetics and phylogenetic analysis of Aloe vera plants

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