In vitro Antioxidant Activity of Itrifal Kishneezi: A Unani Formulation

Koneru, Anupama; Satyanaray, S.; Mukkanti, K.; Khan, K. Abedulla

doi:10.3923/ajdd.2011.121.128

Cited by 14 publications

(4 citation statements)

References 14 publications

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“…The medicinal properties of plants have been the centre of attraction for researchers in recent scientific developments throughout the world, due to their potent antioxidant properties and economic viability [20]. …”

Section: Discussionmentioning

confidence: 99%

Evaluation of Antioxidant and Wound Healing Potentials ofSphaeranthus amaranthoidesBurm.f.

Geethalakshmi

Sakravarthi

Kritika

et al. 2013

BioMed Research International

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Background. Sphaeranthus amaranthoides commonly known as sivakaranthai is used in folklore medicine for the treatment of skin diseases. Methods. The antioxidant activity of the extract and its fraction was evaluated by using 2, 2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging activity, total antioxidant capacity, and total phenolic content. The tested plant extracts showed variable degrees of antioxidant activity. In the present study, methanolic extract of the whole plant of S. amaranthoides and a flavonoid fraction obtained from column chromatography were studied for wound healing activity by incorporating the sample in simple ointment base. Wound healing activity was studied in excision wound model in rats, following which, wound contraction, period of epithelization, hydroxyproline content, and collagen levels in the scab were studied. Results. Methanolic extract showed the highest antioxidant effect (72.05%) and diethyl ether extract has the least (29.34%) compared to the standard (74.53%). Treatment of wound with ointment containing 5% (w/w) methanolic extract and 5% (w/w) flavonoid fraction exhibited better wound healing activity than positive control (silver sulfadiazine). Finally, histopathology studies conformed wound healing activity in Sphaeranthus amaranthoides. The methanolic extract and flavonoid fraction exhibited good wound healing activity probably due to the presence of phenolic and flavonoid constituents. The methanolic extract and flavonoid fraction significantly enhanced the rate of wound contraction and the period of epithelialization comparable to silver sulfadiazine.

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Section: Discussionmentioning

confidence: 99%

Evaluation of Antioxidant and Wound Healing Potentials ofSphaeranthus amaranthoidesBurm.f.

Geethalakshmi

Sakravarthi

Kritika

et al. 2013

BioMed Research International

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“…Reactive oxygen species (ROS) are highly reactive and can damage lipids, proteins and DNA (Arteel, 2003). The ROS, the main culprit, the other one being reactive nitrile species (RNS) are capable of damaging several cellular components such as proteins, lipids and DNA (Koneru et al, 2011). Liver is the primary organ for the metabolism of ingested alcohol (Shanmugam et al, 2010).The liver is the largest, important organ and the site for essential biochemical reactions in the human body.…”

Section: Introductionmentioning

confidence: 99%

Ameliorative effect of pumpkin oil (Cucurbita pepo L.) against alcohol-induced hepatotoxicity and oxidative stress in albino rats

Seif

2014

Beni-Suef University Journal of Basic and Applied Sciences

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Oxidative stress a b s t r a c tObjective: The aim of the present study was to evaluate the protective role of pumpkin oil on experimental alcohol e induced hepatotoxicity. Materials and methods: Rats are divided into three groups of 10 animals each. Group one (G1) was the control group is orally given distilled water for 4 weeks. Group two (G2) is given absolute ethyl alcohol (10%) in drinking water for 4 weeks. Group three (G3) alcohole administered rats were pretreated with pumpkin oil (50 mg/kg body weight) three times per week for three weeks and alcohol (10%) three times per week (at the first two weeks of the experiment). Results: Alcohol caused a marked rise in serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and gamma glutamyl transferase (gGT) activities. Concerning oxidative stress and antioxidant defense system, the depleted hepatic glutathione content, glutathione-S-transferase and catalase activities of alcoholadministered rats were potentially increased above normal levels as a result of pretreatment with pumpkin oil. However, while elevated lipid peroxidation was noticed in alcohol treated rats, pretreatment with pumpkin oil produced a detectable decrease in lipid peroxidation level. Conclusion: The natural plant components found in pumpkin could improve the liver against alcohol-induced liver toxicity and oxidative stress. However, further clinical studies are required to assess the safety and benefits of pumpkin oil in human beings.

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“…[45] Study of diabetic peripheral neuropathy and therapeutic evaluation of Unani formulation Habbe Azaraqi in its management exhibited significant improvement in pain (P < 0.05), numbness (P < 0.001), burning sensation (P < 0.001), and paresthesia (P < 0.05) in subjective parameters in intragroup comparison. [46] Itrifal Kishneezi showed considerable in vitro antioxidant activity in a dosedependent manner [47] [48][49][50][51][52] 4-Hydroxyleucine (amino acid) mainly distributed in fenugreek increased glucose-stimulated insulin release by isolated islet cells in rats, mice, and humans. [53][54][55][56] Babool (Aqaqia/Samaghe Arabi)…”

Section: Capsule Gurmarmentioning

confidence: 99%

Unani Formulations for Management of Diabetes: An Overview

Hamiduddin¹

2018

IJGP

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Diabetes is a leading cause of death. In India, total number of diabetic patients is expected to be 79.4 million in 2030. It is a multifactorial disease leading to several complications. Traditional medicines are being looked up once again for its treatment; the WHO also recommended its further investigation. In this review, these drug its pharmacological activity and its formulation in Greco-Arab or Unani Medicine in India is explored. Singledrug used in formulation with reported anti-diabetic and related beneficial property are Gymnema sylvestre, Azadirachta indica, Aloe vera, Momordica charantia, Acacia arabica, Eugenia jambolana, Trigonella foenum graecum, Punica granatum, etc. Phytomedicine used in Unani medicine presents an exciting opportunity for the development of new types of therapeutics for diabetes mellitus with a holistic approach, which includes various photochemical groups such as alkaloids, terpenes, and phenolics. Beside hypoglycemic activity, these drugs also have antioxidants, bitter and other activity related to disturbance in carbohydrate metabolism. They are used in the form of decoctions, infusions, tablets, pills, and powder such as Qurse Dhayabitus, Qurse Tabasheer, Safoof Gilo, Qurse Marwareed, Qurse Gulnar, Dawaul Misk Talkh, Sharbate Afsanteen, Roghane Qusht, and Ma-Usshaeer and common marketed formulation is Dolabi tablets, Qurs Kushta baiza murgh, Qurs Kushta Zamarrud, Qurs Ziabetus, Safoof Ziabtes, Diab-eaze, etc. There is the tremendous scope of Unani single and compound formulations in the comprehensive management of diabetes particularly Type-2 diabetes; it can also be utilized as an adjuvant with the conventional drug due to its diverse and related beneficial pharmacological activity in diabetes.

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In vitro Antioxidant Activity of Itrifal Kishneezi: A Unani Formulation

Cited by 14 publications

References 14 publications

Evaluation of Antioxidant and Wound Healing Potentials ofSphaeranthus amaranthoidesBurm.f.

Evaluation of Antioxidant and Wound Healing Potentials ofSphaeranthus amaranthoidesBurm.f.

Ameliorative effect of pumpkin oil (Cucurbita pepo L.) against alcohol-induced hepatotoxicity and oxidative stress in albino rats

Unani Formulations for Management of Diabetes: An Overview

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