In vitro antioxidant activity and in vivo antidepressant-like effect of α-(phenylselanyl) acetophenone in mice

Gerzson, Mariana Freire Barbieri; Victoria, Francine Novack; Radatz, Cátia S.; Gomes, Marcelo Gomes de; Boeira, Silvana Peterini; Jacob, Raquel G.; Alves, Diego; Jessé, Cristiano Ricardo; Savegnago, Lucielli

doi:10.1016/j.pbb.2012.03.016

Cited by 44 publications

(19 citation statements)

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“…In the last two decades, the interest in organoselenium biochemistry and pharmacology has increased due to a variety of compounds that show biological activity (May, 1999;Nogueira et al, 2004, Nogueira & Rocha, 2011. In fact, its compounds show antioxidant (Gerzson et al, 2012;Luchese et al, 2009;Nogueira et al, 2004;Prigol et al, 2009), neuroprotective (Porciúncula et al, 2003), antidepressant-like (Gerzson et al, 2012;Oliveira et al, 2012;Savegnago et al, 2008), antihypertensive, anticancer, antiviral, immunosuppressive, and antimicrobial properties (May, 1999;Nogueira et al, 2004;Schewe, 1995). Recently, our group of research showed hepatoprotective effect of bis(4-methylbenzoyl) diselenide (BMD), an disubstituted diaryl diselenide, against carbon tetrachloride (CCl 4 )-induced oxidative damage in mice possibly by modulating the antioxidant status (Filho et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Antinociceptive and anti-hyperalgesic effects of bis(4-methylbenzoyl) diselenide in mice: Evidence for the mechanism of action

Donato

Pavin

Goes

et al. 2014

Pharmaceutical Biology

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(2015) Antinociceptive and anti-hyperalgesic effects of bis(4-methylbenzoyl) diselenide in mice: Evidence for the mechanism of action, Pharmaceutical Biology, 53:3, 395-403, DOI: 10.3109/13880209.2014 -nitro-L-arginine ( L-NOARG), but the effect of BMD was not abolished by naloxone. Mechanical hyperalgesia induced by Cg and CFA was attenuated by BMD, 70 ± 4% and 65 ± 4%, respectively. Furthermore, a single oral dose of BMD did not change plasma aspartate (AST) and alanine aminotransferase (ALT) activities or urea and creatinine levels. Conclusion: BMD demonstrated as a promising compound because of the antinociceptive and anti-hyperalgesic properties in mice.

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Section: Introductionmentioning

confidence: 99%

Antinociceptive and anti-hyperalgesic effects of bis(4-methylbenzoyl) diselenide in mice: Evidence for the mechanism of action

Donato

Pavin

Goes

et al. 2014

Pharmaceutical Biology

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“…Furthermore, in the search for new molecules useful for the treatment of neurological disorders, organoselenium compounds have demonstrated pharmacological potential (Brüning et al, 2011;Gerzson et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

“…The redox activity of selenium-containing molecules has been suggested that they could provide antioxidants of considerable potency (Nogueira et al, 2004;Parnham et al, 1991). Furthermore, these compounds have neuroprotective properties (Brunning et al, 2012;Moussaoui et al, 2000;Nogueira and Rocha, 2010;Pinton et al, 2013), antidepressant and antioxidant activities (Gai et al, 2012;Hassan et al, 2011;Jesse et al, 2011;Gerzson et al, 2012;Martinez et al, 2013;Savegnago et al, 2013;Victoria et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and antidepressant-like activities of semi-synthetic α-phenylseleno citronellal

Victoria

Anversa

Penteado

et al. 2014

European Journal of Pharmacology

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In this study, the antioxidant and antidepressant-like activities of the semi-synthetic compound α-phenylseleno citronellal (PhSeCIT) and the natural terpenoid R-citronellal (CIT) were evaluated. The biological potential of PhSeCIT and CIT was evaluated by antioxidant in vitro assays, such as 1,1-diphenyl-2-picryl-hydrazyl (DPPH), 2,2-azinobis(3-ethylbenzothiazoline-6-sulfonate) (ABTS), ferric ion reducing antioxidant power (FRAP) and linoleic acid oxidation. The compounds were also assessed by ex vivo tests to determine the acute toxicity, levels of thiobarbituric acid reactive species (TBARS), δ-aminolevulinate dehydratase (δ-Ala-D) and Na(+)/K(+) ATPase activities. The antidepressant-like activity of compounds in the tail suspension test (TST) and forced swimming test (FST) was also investigated. The results demonstrated that the addition of an organoselenium group to (R)-citronellal increased its antioxidant properties, since PhSeCIT showed better activity than CIT. The treatment of mice with both compounds did not cause death of any animals. The levels of TBARS were significantly reduced by PhSeCIT in liver and cortex of animals, whereas CIT did not alter these parameters. In the TST and FST, PhSeCIT showed promising antidepressant-like activity, while CIT was not active in this test. Taken together, these data demonstrate the role of selenium in the antioxidant and antidepressant-like activities of (R)-citronellal.

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“…Such tests included the forced swim test (FST) [18,48,56] and tail suspension test (TST) [13,18,56]. In such work, the pretreatment of mice with dopamine D 1 , D 2 and D 3 receptor antagonists (haloperidol, SCH23390 (R-(þ)-8-chloro-2,3,4,5-tetrahydro-3-methyl-5-phe-nyl-1H-3-benzazepine-7-ol) and sulpiride) prevented the anti-immobility effect of methyl phenyl selenide in the FST [47].…”

Section: Preclinical Studiesmentioning

confidence: 99%

Selenium and manganese in depression – preclinical and clinical studies

Sławińska

Bielecka

Iwaniak

et al. 2017

Current Issues in Pharmacy and Medical Sciences

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According to the World Health Organization estimates, approximately 10% of the world's population is affected by depressive disorders. Furthermore, even in high-income countries, many people with depression are not treated, which can lead to serious health consequences and a global economic loss. Unfortunately, the current pharmacotherapy of depressive disorders is characterized by unsatisfactory efficacy and the therapeutic effect is accompanied by many side effects. For this reason, there is still ongoing worldwide research to find new antidepressant therapies. In recent years, many data have been shown that essential elements demonstrate the antidepressant action and increase the effect of antidepressants. In this paper we present the results from the preclinical and clinical studies published over the years which show the involvement of selenium and manganese in depressive disorders. In this article, the relationship between the amount of these microelements in a diet and depression is reviewed and what's more, the association among these elements in different biomaterial and their relations to depressive symptoms is presented. Additionally, we discuss the possible influence of selenium and manganese on modulating neurotransmitter system involved in depression.

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In vitro antioxidant activity and in vivo antidepressant-like effect of α-(phenylselanyl) acetophenone in mice

Cited by 44 publications

References 71 publications

Antinociceptive and anti-hyperalgesic effects of bis(4-methylbenzoyl) diselenide in mice: Evidence for the mechanism of action

Antinociceptive and anti-hyperalgesic effects of bis(4-methylbenzoyl) diselenide in mice: Evidence for the mechanism of action

Antioxidant and antidepressant-like activities of semi-synthetic α-phenylseleno citronellal

Selenium and manganese in depression – preclinical and clinical studies

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