In vitro antioxidant activity and in vivo hepatoprotective activity of aqueous extract of Allium cepa bulb in ethanol induced liver damage in Wistar rats

Kilari, Eswar Kumar; Harsha, K.N.; Sudheer, V.; Babu, N. Chitti

doi:10.1016/j.fshw.2013.10.001

Cited by 22 publications

(2 citation statements)

References 29 publications

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“…The hydroxyl radical scavenging activity of P. niruri leaf extract was measured according to a modified method by Eswar Kumar et al [20]. The reaction mixture contained 60 μ L of 1.0 mM FeCl 2 , 90 μ L of 1 mM 1,10-phenanthroline, 2.4 mL of 0.2 M phosphate buffer (pH 7.8), 150 μ L of 0.17 M hydrogen peroxide (H 2 O 2 ), and 1.5 mL of different concentrations of the extract (20–300 μ g/mL).…”

Section: Methodsmentioning

confidence: 99%

Aqueous Extract of Phyllanthus niruri Leaves Displays In Vitro Antioxidant Activity and Prevents the Elevation of Oxidative Stress in the Kidney of Streptozotocin‐Induced Diabetic Male Rats

Giribabu

Rao

Kumar

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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P. niruri has been reported to possess antidiabetic and kidney protective effects. In the present study, the phytochemical constituents and in vitro antioxidant activity of P. niruri leaf aqueous extract were investigated together with its effect on oxidative stress and antioxidant enzymes levels in diabetic rat kidney. Results. Treatment of diabetic male rats with P. niruri leaf aqueous extract (200 and 400 mg/kg) for 28 consecutive days prevents the increase in the amount of lipid peroxidation (LPO) product, malondialdehyde (MDA), and the diminution of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) activity levels in the kidney of diabetic rats. The amount of LPO showed strong negative correlation with SOD, CAT, and GPx activity levels. P. niruri leaf aqueous extract exhibits in vitro antioxidant activity with IC50 slightly lower than ascorbic acid. Phytochemical screening of plant extract indicates the presence of polyphenols. Conclusion. P. niruri leaf extract protects the kidney from oxidative stress induced by diabetes.

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Section: Methodsmentioning

confidence: 99%

Aqueous Extract of Phyllanthus niruri Leaves Displays In Vitro Antioxidant Activity and Prevents the Elevation of Oxidative Stress in the Kidney of Streptozotocin‐Induced Diabetic Male Rats

Giribabu

Rao

Kumar

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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“…Hepatoprotective action of an aqueous extract of Allium cepa bulb was found against ethanolinduced hepatotoxicity. 96…”

Section: Hepatoprotective Activitymentioning

confidence: 99%

Green synthesis of silver nitrate (AgNO) mediated herbal antimicrobial aqueous extracts of Ocimum basilicum (Basil Leaves)

Rani

2023

IJCAAP

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Green antimicrobial herbal preparations have emerged as cost effective, non-toxic and sustainable approach that involves the use of eco-friendly and non-toxic plant herbs and spices extracts. Green synthesis of silver-treated herbal extracts of Ocimum basilicum (basil leaves extracts) is well known for its safe and cost-effective approach due to having antimicrobial activity to treat various influenza like symptoms, antistress and antidepressant properties. Herbal plant leaf extracts have also been reported to contain an active reducing agent that can reduce metal ions to synthesize biogenic metal nanoparticles. Silver itself, is well reported for their bactericidal properties and also enhance antimicrobial properties when used to prepare biogenic silver nanoparticles from herbal and other biological sources. Hence, we prepared silver nitrate (AgNO) mediated herbal formulations of (basil extracts) that showed significant antibacterial activity against gram-negative bacteria, Escherichia coli BL21 strain. Moreover, this green approach can be more promising to prepare antimicrobial of silver-treated formulations using Ocimum basilicum extracts. It might be safe and cost effective herbal based preparations including nanosuspensions that can further proposed for clinical practices to treat various microbial pathogenesis.

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Plants of Indian Traditional Medicine with Antioxidant Activity

Das

Chaudhuri

Sarkar

et al. 2017

Nutritional Antioxidant Therapies: Treatments and Perspectives

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In vitro antioxidant activity and in vivo hepatoprotective activity of aqueous extract of Allium cepa bulb in ethanol induced liver damage in Wistar rats

Cited by 22 publications

References 29 publications

Aqueous Extract of Phyllanthus niruri Leaves Displays In Vitro Antioxidant Activity and Prevents the Elevation of Oxidative Stress in the Kidney of Streptozotocin‐Induced Diabetic Male Rats

Aqueous Extract of Phyllanthus niruri Leaves Displays In Vitro Antioxidant Activity and Prevents the Elevation of Oxidative Stress in the Kidney of Streptozotocin‐Induced Diabetic Male Rats

Green synthesis of silver nitrate (AgNO) mediated herbal antimicrobial aqueous extracts of Ocimum basilicum (Basil Leaves)

Plants of Indian Traditional Medicine with Antioxidant Activity

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