In vitro antioxidant activity and enzyme inhibition properties of wheat whole grain, bran and flour defatted with hexane and supercritical fluid extraction

Synthesis, crystal structure, and antidiabetic property of hydrazine functionalized Schiff base: 1,2-Di(benzylidene)hydrazine

“…The antidiabetic study of the synthetic Schiff base was carried out following a review of the literature [39]. The reaction mixture was prepared by adding 25 mL of sample solution (100-400 µg/mL), 50 μL of α-amylase (10 µ/mL) solution in phosphate buffer (pH = 6.9) and 50 µL of starch solution (0.05%).…”

Visiblelight-induced ternary electron donor–acceptor complex enabled synthesis of 2-(2-hydrazinyl) thiazole derivatives and the assessment of their antioxidant and antidiabetic therapeutic potential

“…7c) and 4g (206.64 µg ml −1 ) showed a moderate α-amylase inhibitory activity. 19 The generation of free radicals, especially reactive oxygen species (ROS) is a common mediator of apoptosis which can further turn on the programmed cell death. The production of ROS and oxidative stress can lead to chronic hyperglycemia which consequently leads to insulin resistance, β cell degeneration, and glucose intolerance.…”

Elucidation of phenolic metabolites in wheat seedlings (Triticum aestivum L.) by NMR and HPLC-Q-Orbitrap-MS/MS: Changes in isolated phenolics and antioxidant effects through diverse growth times

“…Natural metabolites have increased in popularity owing to their health functions and valuable nutrients during the past years ( Deseo et al, 2020 , Hwang et al, 2021 , Ra et al, 2020 , Sahu et al, 2021 , Zhang et al, 2015 ). In secondary metabolites, including phenolic compounds, terpenoids, anthocyanins, and alkaloids are commonly distributed in crops, fruits, vegetables, and food products ( Celli et al, 2011 , Dai et al, 2015 , del Baño et al, 2003 , Ha et al, 2021 ).…”

“…Moreover, these phytochemicals display human health-promoting properties such as antioxidant, anti-aging, antidiabetic, anticancer, antiviral, and cholesterol-lowering effects. ( Sahu et al, 2021 , Shewry and Hey, 2015 , Teixeira et al, 2020 , Xie et al, 2019 , Zhang et al, 2015 ). In addition, the profiles and concentrations of phenolic metabolites in metabolite-rich foods and their products exhibited remarkable differences according to climate, genetics, soil, farming method, processing skill, and microorganism ( Escudero-López et al, 2014 , Lee et al, 2015 , Lee et al, 2016 , Ramakrishna and Ravishankar, 2011 , Tian et al, 2021 ).…”

“…Based on these considerations, numerous researchers recently focused on the appropriate factors influencing the strong functional abilities and high phenolic contents of crops. Among diverse materials, wheat ( Triticum aestivum L.) is one of the most valuable crops due to its effects in the human diet, including the reduction of diabetes, cardiovascular disease, cancer, and obesity, in addition to a preventive effect against chronic inflammation ( Chen et al, 2019 , Gawlik-Dziki et al, 2016 , Ra et al, 2020 , Riaz et al, 2017 , Sahu et al, 2021 ). This crop is also of considerable interest in the food industry and applications concerning the human diet because of its high protein and carbohydrate concentrations ( Shewry & Hey, 2015 ).…”