In vitro antioxidant activities of Tussilago farfara, a new record species to Changbai Mountain

Li, Changtian; Yanpeng, Liu; He, Feng-Cheng; Yu, Liang

doi:10.1016/s1875-5364(12)60052-1

Cited by 2 publications

(3 citation statements)

References 11 publications

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“…Additionally, cytotoxicity was not observed in BEAS 2B cells. These results are in agreement with previous results [26,27]. In the latter paper it was shown that the methanol leaf extract of T. farfara produced no cytotoxic effect on the human liver cell line Huh7.…”

Section: Discussionsupporting

confidence: 93%

“…farfara and V. thapsus extracts prepared in different ways and with different solvents were shown to exhibit antibacterial, antiviral and antifungal properties [6,11,22,23]. Antioxidant and free radical scavenging activities of these plants were also shown using mostly biochemical assays [5,[24][25][26]. The present study was designed to examine the potential toxic and antioxidative effects of the water extracts of T. farfara and V. thapsus in two model systems, in vitro in BEAS 2B epithelial bronchial cells and in vivo in zebrafish embryos.…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of toxicity and antioxidative effects of Tussilago farfara and Verbascum thapsus water extracts in zebrafish and in bronchial epithelial cells

Dragičević

Kovačević

Rankov

et al. 2019

Arch biol sci (Beogr)

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Tussilago farfara (coltsfoot) and Verbascum thapsus (mullein) have been used as folk remedies for treating respiratory disorders. The aim of this study was to test the toxicity of the water extracts of T. farfara and V. thapsus in vivo in zebrafish and in vitro in BEAS 2B epithelial bronchial cells. To the best of our knowledge, this is the first study to investigate the antioxidative properties of T. farfara and V. thapsus extracts in cell culture. Our results show that the T. farfara leaf extract does not produce toxic effects on zebrafish embryos or BEAS 2B cells, and that it has a protective effect in BEAS 2B after induction of oxidative stress. The water extract from V. thapsus displayed pronounced toxic effects on zebrafish embryos and BEAS 2B cells and did not exhibit a significant antioxidative effect on BEAS 2B cells exposed to oxidative stress. Our results suggest that the use of T. farfara water leaf extract is potentially safe and effective in treating respiratory disorders, whereas the use of V. thapsus needs further investigation. [Project of the Serbian Ministry of Education, Science and Technological Development, Grant no. ON173008]

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Evaluation of toxicity and antioxidative effects of Tussilago farfara and Verbascum thapsus water extracts in zebrafish and in bronchial epithelial cells

Dragičević

Kovačević

Rankov

et al. 2019

Arch biol sci (Beogr)

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“…In addition, polysaccharides extracted from Taraxacum have also shown antioxidant properties of scavenging free radical 16 . Furthermore, the ethyl acetate, n-butanol and water extracts from Tussilago farfara L. were found to be high in antioxidant abilities 17 . However, there is little information about the antioxidant properties of polysaccharides from Tussilago farfara L..…”

Section: Introductionmentioning

confidence: 98%

Evaluation of Antioxidant Activity of Polysaccharides from Tussilago farfara L. by Flow Injection Analysis

Qin¹,

Liu²,

Yong-xiu³

et al. 2014

Asian J. Chem.

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In this study, water-soluble crude polysaccharides from Tussilago farfara L. and the polysaccharides, deproteinized and decolorized from the crude polysaccharides were obtained. We evaluated the antioxidant activities of crude polysaccharides and deproteinized polysaccharides in vitro by flow injection analysis chemiluminescence (FIA-CL), based on the inhibition effect of their natural antioxidants on the free radical-induced luminol chemiluminescence. Ascorbic acid was used as positive control. At the optimum operational conditions, the antioxidant activity was measured by plotting the inhibition vs. the content of samples to calculate the IC50. The results showed that deproteinized polysaccharides showed higher scavenging activities on the reactive oxygen species such as superoxide anion radical, hydroxyl radical and hydrogen peroxide than that of crude polysaccharides, but less than that of ascorbic acid. This suggests that Tussilago farfara is a good natural antioxidant and has the potential to be used in the manufacturing of foods and medicines.

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In vitro antioxidant activities of Tussilago farfara, a new record species to Changbai Mountain

Cited by 2 publications

References 11 publications

Evaluation of toxicity and antioxidative effects of Tussilago farfara and Verbascum thapsus water extracts in zebrafish and in bronchial epithelial cells

Evaluation of toxicity and antioxidative effects of Tussilago farfara and Verbascum thapsus water extracts in zebrafish and in bronchial epithelial cells

Evaluation of Antioxidant Activity of Polysaccharides from Tussilago farfara L. by Flow Injection Analysis

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