In vitro antimicrobial susceptibility of Mycoplasma hominis genital isolates

Pignanelli, Salvatore; Pulcrano, Giovanna; Schiavone, Pasqua; Iula, Vita Dora; Catania, Maria Rosaria

doi:10.4103/0378-6323.153520

Cited by 6 publications

(3 citation statements)

References 11 publications

(59 reference statements)

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“…Josamycin was not included in our study since it has not been used in Romania yet. Other studies reported that, for Ureaplasma species, josamycin, minocycline and doxycycline were highly and equally effective (for josamycin S = 90%, I = 8% and R = 1%) [19]. Moreover, new quinolones should also be considered (trovafloxacin, sparfloxacin, moxifloxacin, gemifloxacin and gatifloxacin) since studies have shown that mollicutes were more susceptible to them than to the classic quinolones [12,20,21].…”

Section: Figure 3 Antimicrobial Susceptibility Of U Urealyticum Genit...mentioning

confidence: 99%

Antimicrobial Resistance of Ureaplasma Urealyticum and Mycoplasma Hominis in the Romanian Population

CUTOIU¹

2023

FARMACIA

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The present study aimed to assess the antimicrobial susceptibility and resistance to antibiotics available in Romania against Ureaplasma urealyticum and Mycoplasma hominis genital isolates at this time. We collected urethral swabs and vaginal samples from patients who presented at "Ponderas" Academic Hospital (Bucharest, Romania) in the Dermato-venereology Department from January 2021 until December 2021. Fifty-two samples were obtained from two groups of patients: symptomatic subjects complaining of several urogenital symptoms (i.e. burning sensation or pain during urination, vaginal/cervical discharge etc.) and completely asymptomatic subjects who came for sexually transmitted diseases (STDs) microbiological screening. We used a Mycoplasma kit to assess the presence of U. urealyticum and M. hominis and their susceptibility to antibiotics. 82% of men (n = 28) were diagnosed with U. urealyticum genital infection. 50% of females (n = 9) were positive for both U. urealyticum and M. hominis (p = 0.01914). All isolates (100%, n = 52) were susceptible to doxycycline and tetracycline. Most mollicutes showed significant resistance to quinolones. Mollicutes showed a better susceptibility to macrolides when only one isolate was present (76%, 73% and 84% for erythromycin, azithromycin and clarithromycin, respectively) compared to mixed isolates (7%) (p < 0.001). Multiple antibiotic resistance (MAR) index was calculated, and the result was 0.33 for U. urealyticum isolates, 0.64 for genital coinfection with mixed isolates, and 0.42 for M. hominis isolate (p = 0.0003614). In conclusion, our study analysed the antibiotic susceptibility of U. urealyticum and M. hominis in urethral and vaginal samples in the Romanian population, for a better understanding of the rational use of antibiotics, which may be helpful to avoid both treatment failure and the abuse of antimicrobial agents. RezumatAcest studiu și-a propus să evalueze susceptibilitatea și rezistența la antibioticele disponibile în România la momentul actual a izolatelor genitale de Ureaplasma urealyticum și Mycoplasma hominis. S-au recoltat probe uretrale și vaginale de la pacienti care s-au prezentat la Spitalul Academic "Ponderas" (București, România) în Secția de Dermato-venerologie în perioada ianuarie -decembrie 2021. Au fost obținute 52 de probe de la două grupuri diferite de pacienți: subiecți simptomatici cu unul sau mai multe simptome uro-genitale (senzație de arsură sau durere în timpul micțiunii, secreții uretrale/vaginale/cervicale etc.) și subiecți complet asimptomatici care au venit pentru screening pentru boli cu transmitere sexuală (BTS). S-a folosit un kit special pentru a evalua prezența U. urealyticum și M. hominis și susceptibilitatea acestora la antibiotice. 82% dintre bărbați (n = 28) au fost diagnosticați cu infecție genitală cu U. urealyticum. 50% dintre femei (n = 9) au fost pozitive atât pentru U. urealyticum, cât și pentru M. hominis (p = 0,01914). Toate izolatele (100%, n = 52) au fost susceptibile la doxiciclină și tetraciclină. Majoritatea mol...

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Section: Figure 3 Antimicrobial Susceptibility Of U Urealyticum Genit...mentioning

confidence: 99%

Antimicrobial Resistance of Ureaplasma Urealyticum and Mycoplasma Hominis in the Romanian Population

CUTOIU¹

2023

FARMACIA

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“…As can be seen from Table 1, then prevalence varies considerably from study to study [1][2][3][4][5]. Prevalence of M. genitalium has been found to be between 0.3-1.2% [6,7].…”

Section: Epidemiologymentioning

confidence: 99%

“…Resistance to erythromycin has been reported additionally by Ponyai et al [31] and Krausse et al [33] who determined that the resistance of ureaplasmas to erythromycin is 81% and 21%, respectively. Pignanelly et al [5] studied M. hominis and found that the isolates were sensitive to tetracycline and doxycycline but resistant to fluoroquinolones and macrolides except jocamycin. Krausse et al [33] found that doxycycline was the most active tetracycline against ureaplasmas and M. hominis.…”

Section: General Treatmentmentioning

confidence: 99%

Urogenital Mycoplasmosis and Pregnancy

Põder¹,

Haldre²

2016

J Antimicrob Agents

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Urogenital mycoplasmas Ureaplasma urealyticum, Ureaplasma parvum and Mycoplasma hominis have long been considered commensals of human urogenital microflora. Several studies have recently clarified whether these bacteria could cause or be associated with various obstetric complications. Epidemiologic studies have found high prevalence of Ureaplasma spp. and M. hominis among otherwise healthy population. On the other hand, U. urealyticum, U. parvum and M. hominis have increasingly been linked to adverse pregnancy outcomes such as spontaneous pre-term labor, pre-term premature rupture of fetal membranes, miscarriage, stillbirth and low birth weight. However, no convincing causal relationship has been shown. Studies have shown that antibiotics resistance is on the rise and differs considerably by regions. Screening of asymptomatic patients for M. hominis, U. urealyticum and U. parvum is currently still not indicated.

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