In vitro antimicrobial activity of extracts and isolated constituents of Geum rivale

Panizzi, L.; Catalano, S.; Miarelli, C.; Cioni, P. L.; Campeol, Elisabetta

doi:10.1002/1099-1573(200011)14:7<561::aid-ptr651>3.3.co;2-8

Cited by 12 publications

(20 citation statements)

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“…The antibacterial activity of an extract of G. rivale and isolated compounds including UA was moderately active against S. aureus, P. aeruginosa and E. coli [47]. Antibacterial activity against eight bacterial species was also reported for UA and its derivatives isolated from whole plants of Rostellularia procumbens (Acientaceae).…”

Section: Staphylococcus Aureus Staphylococcus Saprophytus Streptocomentioning

confidence: 83%

“…Likewise, OA isolated from Syzygium guineense (Myrtaceae) did not inhibit the growth of E. coli, S. sonnei or B. subtilis, as estimated using bioauthography on thin-layer plates [46]. In a paper by Panizzi and coworkers it was shown that OA isolated from an extract of Geum rivale (Rosaceae) was not active against S. aureus, E. coli or P. aeruginosa [47], as determined by quantitative screening of bacterial number using the agar well diffusion assay [48]. Wächter and coworkers demonstrated poor antitubercular activity of OA-derivatives isolated from Lippia turbinata (Verbenaceae), with MIC values varying from 64 mg mL -1 to 128 mg mL -1 [49].…”

Section: Antibacterial Activity Of Oa and Its Derivativesmentioning

confidence: 99%

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Antibacterial activity of oleanolic and ursolic acids and their derivatives

et al. 2010

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Bacterial resistance to antibiotics is increasing at an alarming rate and many commonly used antibiotics are no longer effective.Thus, there is considerable interest in investigating novel antibacterial compounds, such as the plant-derived pentacyclic triterpenoids, including oleanolic acid (OA), ursolic acid (UA) and their derivatives. These compounds can be isolated from many medicinal and crop plants and their antibacterial, antiviral, antiulcer and anti-inflammatory effects are well documented. OA and UA are active against many bacterial species, particularly Gram-positive species, including mycobacteria. They inhibit bacterial growth and survival, and the spectrum of minimal inhibitory concentration (MIC) values is very broad. In addition, OA, UA and their derivatives display potent antimutagenic activity. Studies to identify the cellular targets and molecular mechanisms of OA and UA action were initiated a few years ago and it has already been demonstrated that both acids influence bacterial gene expression, the formation and maintenance of biofilms, cell autolysis and peptidoglycan turnover. Before these compounds can be used clinically as antimicrobial agents, further extensive studies are required to determine their cytotoxicity and the optimum mode of their application.

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Section: Staphylococcus Aureus Staphylococcus Saprophytus Streptocomentioning

confidence: 83%

Section: Antibacterial Activity Of Oa and Its Derivativesmentioning

confidence: 99%

Antibacterial activity of oleanolic and ursolic acids and their derivatives

et al. 2010

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“…Analyses of the chemical composition of those species have revealed the presence of some triterpenes, sterols and flavonoids, as well as small amounts of essential oil (Vollmann and Schultze, 1995;Panizzi et al, 2000). It is tannins, however, that are considered to be the main group of constituents responsible for the activity and medicinal usefulness of the plants (Blinova, 1954;Strzelecka and Kowalski, 2000).…”

Section: Introductionmentioning

confidence: 99%

“…Most of them are believed to be hydrolyzable gallo-and ellagitannins (Blinova, 1954). Free EA and GA have also been isolated from the plants (Gstirner and Widenmann, 1964;Panizzi et al, 2000). G. rivale and G. urbanum could be rich sources of EA and GA and this might be reflected in their activity.…”

Section: Introductionmentioning

confidence: 99%

Quantitative Determination of Ellagic Acid and Gallic Acid in Geum Rivale L. and G. Urbanum L.

Owczarek¹,

Olszewska²,

Gudej³

2015

Acta Biologica Cracoviensia S. Botanica

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Hydrolyzable tannins and products of their hydrolysis, ellagic acid (EA) and gallic acid (GA), are important constituents of many medicinal plants and exhibit various biological activities. Geum rivale and G. urbanum are traditional herbal remedies rich in tannin compounds. The aim of the study was to quantitate free and total EA and GA in aerial and underground parts of G. rivale and G. urbanum. After optimization of extraction, both compounds were quantitated by reversed phase HPLC (RP-HPLC). EA was more abundant than GA in the investigated material, and underground parts of G. rivale were the richest source of total EA and GA.K Ke ey y w wo or rd ds s: : Geum rivale, Geum urbanum, phenolic acid, Rosaceae.

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“…Together with closely related G. urbanum L., it has been used in traditional medicine as astringent and antiseptic agent in the treatment of diarrhoea, digestive disorders, and haemorrhoids [2]. Isolation studies concerning the species have so far been limited to the aerial parts and led to the isolation and identification of triterpenoid, flavonoid, and phenolic acid derivatives [3,4]. The plant is also known to accumulate large amounts of tannins, especially in underground organs [5].…”

Section: Introductionmentioning

confidence: 99%

Rare Ellagic Acid Sulphate Derivatives from the Rhizome of Geum rivale L.—Structure, Cytotoxicity, and Validated HPLC-PDA Assay

et al. 2017

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Abstract:Two rare sulphate ellagic acid derivatives were isolated from the rhizome of Geum rivale L. in three simple steps. Their structures were identified by comprehensive NMR studies ( 1 H NMR, 13 C NMR, 1 H-1 H COSY, HMBC, HSQC) as 3,3 -dimethoxy-4-sulphoxyellagic acid potassium salt(1) and 3,3 ,4 -trimethoxy-4-sulphoxyellagic acid potassium salt (2). Subsequently, a new precise (RSD < 2.6%), accurate (recoveries in the range of 96.5-98.7%), and sensitive (LODs in the range of 0.15-0.16 µg/mL) HPLC-PDA procedure was developed for the simultaneous quantification of compounds 1 and 2 in plant material. The rhizome of G. rivale proved to be a good source of both compounds, with the content of 2.94 ± 0.03 and 5.45 ± 0.03 mg/g dw respectively, whereas at most, trace amounts were detected in related plant materials (aerial parts of G. rivale, rhizome and aerial parts of G. urbanum). The cytotoxicity of isolated compounds tested on human leukaemia (promyelocytic HL-60 and lymphoblastic NALM-6) and melanoma (WM 115) cell lines with IC 50 values in the range of 306.4-473.8 µM was demonstrated to be lower than that of ellagic acid (IC 50 = 62.3-300.6 µM).

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In vitro antimicrobial activity of extracts and isolated constituents of Geum rivale

Abstract: The antimicrobial activity of extracts of Geum rivale (Rosaceae) and that of some isolated constituents, on bacteria and fungi, was evaluated. The activity was concentrated in the triterpenes fraction and, for gram+ and gram- bacteria, also in the flavonoids fraction.

Cited by 12 publications

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Antibacterial activity of oleanolic and ursolic acids and their derivatives

Antibacterial activity of oleanolic and ursolic acids and their derivatives

Quantitative Determination of Ellagic Acid and Gallic Acid in Geum Rivale L. and G. Urbanum L.

Rare Ellagic Acid Sulphate Derivatives from the Rhizome of Geum rivale L.—Structure, Cytotoxicity, and Validated HPLC-PDA Assay

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