In vitro antimicrobial activity of cefoperazone-sulbactam combinations against 554 clinical isolates including a review and β-lactamase studies

Jones, Ronald N.; Wilson, Harold W.; Thornsberry, Clyde; Barry, Arthur L.

doi:10.1016/s0732-8893(85)80005-5

Cited by 28 publications

(15 citation statements)

References 16 publications

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“…As a third-generation cephalosporin, cefoperazone has broad-spectrum efficacy (26,27). As a result, it is not surprising that, in the standard chow group, it had a significant impact on microbiota community structure.…”

Section: Discussionmentioning

confidence: 99%

Dietary Xanthan Gum Alters Antibiotic Efficacy against the Murine Gut Microbiota and Attenuates Clostridioides difficile Colonization

Schnizlein

Vendrov

Edwards

et al. 2020

mSphere

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Dietary fiber provides a variety of microbiota-mediated benefits ranging from anti-inflammatory metabolites to pathogen colonization resistance. A healthy gut microbiota protects against Clostridioides difficile colonization. Manipulation of these microbes through diet may increase colonization resistance to improve clinical outcomes. The primary objective of this study was to identify how the dietary fiber xanthan gum affects the microbiota and C. difficile colonization. We added 5% xanthan gum to the diet of C57BL/6 mice and examined its effect on the microbiota through 16S rRNA gene amplicon sequencing and short-chain fatty acid analysis. Following either cefoperazone or an antibiotic cocktail administration, we challenged mice with C. difficile and measured colonization by monitoring the CFU. Xanthan gum administration is associated with increases in fiber-degrading taxa and shortchain fatty acid concentrations. However, by maintaining both the diversity and absolute abundance of the microbiota during antibiotic treatment, the protective effects of xanthan gum administration on the microbiota were more prominent than the enrichment of these fiber-degrading taxa. As a result, mice that were on the xanthan gum diet experienced limited to no C. difficile colonization. Xanthan gum administration alters mouse susceptibility to C. difficile colonization by maintaining the microbiota during antibiotic treatment. While antibiotic-xanthan gum interactions are not well understood, xanthan gum has previously been used to bind drugs and alter their pharmacokinetics. Thus, xanthan gum may alter the activity of the oral antibiotics used to make the microbiota susceptible. Future research should further characterize how this and other common dietary fibers interact with drugs. IMPORTANCE A healthy gut bacterial community benefits the host by breaking down dietary nutrients and protecting against pathogens. Clostridioides difficile capitalizes on the absence of this community to cause diarrhea and inflammation. Thus, a major clinical goal is to find ways to increase resistance to C. difficile colonization by either supplementing with bacteria that promote resistance or a diet to enrich for those already present in the gut. In this study, we describe an interaction between xanthan gum, a human dietary additive, and the microbiota resulting in an altered gut environment that is protective against C. difficile colonization.

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Section: Discussionmentioning

confidence: 99%

Dietary Xanthan Gum Alters Antibiotic Efficacy against the Murine Gut Microbiota and Attenuates Clostridioides difficile Colonization

Schnizlein

Vendrov

Edwards

et al. 2020

mSphere

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“…Many studies have investigated the in vitro activity of cefoperazone-sulbactam combination and have shown it to be superior to that of cefoperazone alone against clinical isolates of many Gram-negative bacilli, but particularly against Acinetobacter species when the activity is due to sulbactam alone [17][18][19]. In vitro studies have shown that cefoperazone-sulbactam is more active than some individual ␤-lactam agents against Acinetobacter species [20].…”

Section: Discussionmentioning

confidence: 99%

In vitro activities of β-lactam antibiotics alone and in combination with sulbactam against Gram-negative bacteria

Wang

Lin

Lee

et al. 2004

International Journal of Antimicrobial Agents

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“…Cefoperazone has a broad spectrum of activity against both grampositive and gram-negative bacteria, which makes it a sititable choice for the treatment of CAPD peritonitis. Sulbactam, a beta-lactamase inhibitor, has been shown to enhance the in vitro spectrum of cefoperazone (8).…”

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confidence: 99%

Pharmacokinetics and pharmacodynamics of cefoperazone-sulbactam in patients on continuous ambulatory peritoneal dialysis

Johnson

Zimmerman

Reitberg

et al. 1988

Antimicrob Agents Chemother

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This study was conducted to determine the pharmacokinetics of the fixed combination antibiotic cefoperazone-sulbactam in patients receiving continuous ambulatory peritoneal dialysis (CAPD). In addition, the pharmacodynamic profile of this combination was determined by the use of mean bactericidal titers against selected bacterial strains. Six noninfected CAPD patients were given a fixed dose of cefoperazone (2 g) and sulbactam (1 g) either intravenously or intraperitoneally over 10 min in a randomized, two-way crossover fashion. The mean peak cefoperazone concentration in serum after intravenous administration was 280.9 ,ug/ml. The mean peak concentration in serum after intraperitoneal cefoperazone administration was 38.9 ,ug/ml and occurred 2 to 4 h postdose. The mean peak sulbactam concentration in serum after intravenous administration was 82.2 ,ug/ml. The mean peak concentration in serum after intraperitoneal sulbactam administration was 24.4 ,ug/ml and occurred at 6 h. The absolute bioavailability of the intraperitoneal dose was 61% for cefoperazone and 70% for sulbactam. Cefoperazone total body and renal clearances were unaffected by renal failure and dialysis. However, both clearance values for sulbactam were reduced markedly. Only intraperitoneal dosing provided peak inhibitory and bactericidal titers in dialysate for all organisms tested.

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In vitro antimicrobial activity of cefoperazone-sulbactam combinations against 554 clinical isolates including a review and β-lactamase studies

Cited by 28 publications

References 16 publications

Dietary Xanthan Gum Alters Antibiotic Efficacy against the Murine Gut Microbiota and Attenuates Clostridioides difficile Colonization

Dietary Xanthan Gum Alters Antibiotic Efficacy against the Murine Gut Microbiota and Attenuates Clostridioides difficile Colonization

In vitro activities of β-lactam antibiotics alone and in combination with sulbactam against Gram-negative bacteria

Pharmacokinetics and pharmacodynamics of cefoperazone-sulbactam in patients on continuous ambulatory peritoneal dialysis

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