In Vitro Antimicrobial Activity of New Substituted Phenylthiazole Derivatives

Souldozi, Ali; Talebi, Reza

doi:10.29252/arakmu.12.1.33

Cited by 2 publications

(2 citation statements)

References 14 publications

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“…Therefore, it can be concluded that in this molecule and generally similar molecules with this structure, the presence of the naphthol moiety adjacent to the thiadiazole ring significantly increases the antimicrobial power and exerts a synergistic effect. The result obtained in this research can play a key role in the synthesis of 16) 200 ( 16) 200 (12) 4b 400 ( 13) 800 ( 16) 400 ( 13) 400 (12) 4c 800 ( 17) 400 ( 25) 400 ( 13) 400 (15) 4d 100 ( 25) 100 ( 25) 50 ( 25) 100 (17) 4e 400 ( 15) 200 ( 25) 200 ( 16) 200 (16) 4f 400 ( 25) 400 ( 18) 200 ( 16) 200 (18) 4g 400 ( 15) 800 ( 25) 200 ( 16) 800 (12) Fluconazole 200 ( 15) 100 ( 17) 200 ( 16) 200 ( 14)…”

Section: Discussionmentioning

confidence: 66%

“…Since the synthesis and evaluation of antimicrobial activity is an important part of our research program (14)(15)(16), in this study, we aimed to evaluate the antibacterial and antifungal activity of these derivatives against some microorganisms that cause the largest number of infections and, in some cases, have exhibited resistance to currently available antibiotics such as Methicillin-resistant Staphylococcus, Staphylococcus aureus, Streptococcus pyogenes, Pseudomonas aeruginosa, Escherichia coli, Candida albicans, Candida tropicalis, Candida krusei, and Candida glabrata.…”

Section: Introductionmentioning

confidence: 99%

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Antimicrobial and Anti-pathogenic Activity of New Naphtho [1,2,4] Triazol-Thiadiazin Derivatives

Kouhkan,

Mahmoody,

Khalafy

et al. 2023

Avicenna J Clin Microbiol Infect

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Background: Antimicrobials are one of the extremely important categories of drugs for the treatment, control, and prevention of microbial diseases, but the development of drug resistance against clinically used antibacterial agents has increased the demand for the design and synthesis of new drugs. We have previously synthesized new series of 10-substituted-5H-naphtho[1,2-e][1,2,4]triazolo[3,4-b] [1,3,4]thiadiazin derivatives (4a-4f). In this study, we evaluated the antimicrobial activity of these derivatives against some pathogenic microorganisms. Methods: The reaction of 2-bromo-1,4-naphthoquinone with 4-amino-5-aryl-4H-1,2,4-triazole-3- thiols in ethanol at 50 ̊C gave the corresponding 2-[(4-amino-5-aryl-4H-1,2,4-triazol-3 yl)thio] naphthalene-1,4- diones. Moreover, their treatment with EtOH/HCl under reflux conditions produced 10-substituted-5H-naphtho[1,2-e][1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-5- ones through intramolecular cyclization. The well agar diffusion and agar dilution methods were used during the preliminary evaluation of antimicrobial activity for the determination of inhibition zone (IZ) and minimum inhibitory concentration (MIC). Results: Seven tetracyclic heterocyclic ring systems were produced under reflux conditions. The structures of all the products were identified by their FT-IR, 1H, and 13C NMR spectral data and by elemental analysis. The results revealed that the antibacterial activity of compounds 4a, 4b, 4c, and 4d are higher than that of the others, and compounds 4d, 4a, 4e, and 4f exerted the greatest effect on fungal samples. Conclusion: All synthesized compounds exhibited promising antibacterial and antifungal activity. In this study, compounds 4a-4g exhibited highly potent antimicrobial activity and acceptable selectivity index against Staphylococcal and Candida infections.

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Section: Discussionmentioning

confidence: 66%

Section: Introductionmentioning

confidence: 99%

Antimicrobial and Anti-pathogenic Activity of New Naphtho [1,2,4] Triazol-Thiadiazin Derivatives

Kouhkan,

Mahmoody,

Khalafy

et al. 2023

Avicenna J Clin Microbiol Infect

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Thiazole Ring: A Pharmacological Active Scaffold

Singh,

Kaur,

Lata

2023

RJPT

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The most important five-membered hetrocyclic molecules with a wide range of biological action are thiazoles. Sulphur atoms are found at position 1 while nitrogen atoms are found at position 3. The goal of this research is to compile a list of activities and innovative methodologies for the synthesis of thiazole derivatives. The entire review discusses thiazole's numerous properties, including antibiotics, antimalarials, antidiabetics, anticancer, anti-inflammatory, diuretics, antimycobactreial, and methods for thiazole synthesis.

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In Vitro Antimicrobial Activity of New Substituted Phenylthiazole Derivatives

Abstract: Background: In this study, we evaluated antibacterial and antifungle activity of these derivatives against gram positive (Staphylococcus aureus, Bacillus subtilis, B. cereus), gram negative (Proteus vulgaris) bacteria and fungale (Candida albicans, C. tropicalis and C. glabrata).

Cited by 2 publications

References 14 publications

Antimicrobial and Anti-pathogenic Activity of New Naphtho [1,2,4] Triazol-Thiadiazin Derivatives

Antimicrobial and Anti-pathogenic Activity of New Naphtho [1,2,4] Triazol-Thiadiazin Derivatives

Thiazole Ring: A Pharmacological Active Scaffold

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