In vitro Antimicrobial Activity of Agents from Spilanthes filicaulis and Laportea ovalifolia against Some Drug Resistant Bacteria

Akoachere, Jane-Francis Tatah Kihla; Yvonne, Suylika; Mbah, Ajeck; Ayimele, Aponglen; Assob, Jules Clément Nguedia; Fodouop, Siméon Pierre Chegaing; Kodjio, Norbert; Gatsing, Donatien

doi:10.9734/bjpr/2015/15582

Cited by 6 publications

(5 citation statements)

References 15 publications

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“…However these plants were previously reported for their antifungal activities [ 29 – 32 ]. The antibacterial activities of extracts from Zehneria scobra and Nauclea latifolia [ 33 , 34 ] were reported on some bacteria: The present study therefore provides additional information on the activity of these plants against MDR Gram-negative phenotypes.…”

Section: Discussionmentioning

confidence: 65%

Antibacterial and antibiotic-modulation activity of six Cameroonian medicinal plants against Gram-negative multi-drug resistant phenotypes

Djeussi

Noumedem

Ngadjui

et al. 2016

BMC Complement Altern Med

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BackgroundBacterial Infections involving multi-drug resistant (MDR) phenotypes constitute a worldwide health concern. The present work was designed to assess the antibacterial properties of the methanol extracts of six medicinal plants (Anthocleista schweinfurthii, Nauclea latifolia, Boehmeria platyphylla, Caucalis melanantha, Erigeron floribundus and Zehneria scobra) and the effects of their associations with antibiotics on MDR Gram-negative bacteria over-expressing active efflux pumps.MethodsThe antibacterial activities and the ability to potentiate antibiotic effects of the methanol extracts the tested plants were evaluated in vitro against twenty eight Gram-negative bacteria expressing MDR phenotypes, using broth microdilution method. The phytochemical screening of these extracts was also performed using standard methods.ResultsAll tested extracts displayed moderate to low antibacterial activity on at least 14.3 % of the 28 tested bacteria, with MIC values ranged from 128 to 1024 μg/mL. The best antibacterial spectrum was observed with Naulcea latifolia bark extract. Extracts from A. schweinfurthii fruits, N. latifolia stem bark, Z. scobra and N. latifolia leaves showed synergistic effects with many antibiotics against MDR bacteria.ConclusionThe overall results of the present study provide information for the possible use of the studied plants, especially Nauclea latifolia in the control of Gram-negative bacterial infections including MDR species as antibacterials as well as resistance modulators.Electronic supplementary materialThe online version of this article (doi:10.1186/s12906-016-1105-1) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 65%

Antibacterial and antibiotic-modulation activity of six Cameroonian medicinal plants against Gram-negative multi-drug resistant phenotypes

Djeussi

Noumedem

Ngadjui

et al. 2016

BMC Complement Altern Med

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“…β-stigmasterol ( 179 ) is a sterol with moderate activity against M. aurum and M. smegmatis . β-stigmasterol was isolated from the stem bark of Tetracera potatoria (Dilleniaceae) and shows potential for tuberculosis, urinary tract infection, and typhoid fever treatments . Stigmast-22-ene-3,6-dione ( 180 ) is a steroid that was isolated from Salvinia auriculata Aubl.…”

Section: Plant-derived Compounds With Antibacterial Propertiesmentioning

confidence: 99%

“…β-stigmasterol was isolated from the stem bark of Tetracera potatoria (Dilleniaceae) and shows potential for tuberculosis, 93 urinary tract infection, and typhoid fever treatments. 467 Stigmast-22-ene-3,6-dione 148 (180) is a steroid that was isolated from Salvinia auriculata Aubl. (Salviniaceae) that is moderately active against S. aureus.…”

Section: Other Metabolitesmentioning

confidence: 99%

Ethnobotany and the Role of Plant Natural Products in Antibiotic Drug Discovery

et al. 2020

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The crisis of antibiotic resistance necessitates creative and innovative approaches, from chemical identification and analysis to the assessment of bioactivity. Plant natural products (NPs) represent a promising source of antibacterial lead compounds that could help fill the drug discovery pipeline in response to the growing antibiotic resistance crisis. The major strength of plant NPs lies in their rich and unique chemodiversity, their worldwide distribution and ease of access, their various antibacterial modes of action, and the proven clinical effectiveness of plant extracts from which they are isolated. While many studies have tried to summarize NPs with antibacterial activities, a comprehensive review with rigorous selection criteria has never been performed. In this work, the literature from 2012 to 2019 was systematically reviewed to highlight plant-derived compounds with antibacterial activity by focusing on their growth inhibitory activity. A total of 459 compounds are included in this Review, of which 50.8% are phenolic derivatives, 26.6% are terpenoids, 5.7% are alkaloids, and 17% are classified as other metabolites. A selection of 183 compounds is further discussed regarding their antibacterial activity, biosynthesis, structure−activity relationship, mechanism of action, and potential as antibiotics. Emerging trends in the field of antibacterial drug discovery from plants are also discussed. This Review brings to the forefront key findings on the antibacterial potential of plant NPs for consideration in future antibiotic discovery and development efforts.

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“…The antibacterial activity of S. dulcis [ 32 ], S. filicaulis [ 33 ] and K. crenata [ 20 ] was earlier reported on Gram negative and Gram positive bacteria including S. aureus . Except K. crenata extract which revealed similar weak activity on S. aureus [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

Anti-Staphylococcus aureus activity of methanol extracts of 12 plants used in Cameroonian folk medicine

et al. 2015

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BackgroundThe emergence of bacterial infections including those associated with Staphylococcus aureus causes a benefit of interest to medicinal plants as an effective means of control. The present study was designed to investigate the activities of 12 selected Cameroonian medicinal plants against S. aureus isolates.MethodsThe plant extracts were prepared by maceration in methanol at laboratory temperature. Qualitative phytochemical analysis was performed by chemical reaction methods. The broth microdilution method was used to evaluate the activities of plant extracts against 11 S. aureus clinical isolates.ResultsDacryodes edulis was found to have significant antibacterial activity on all the S. aureus isolates (MIC = 64–256 µg/ml). Occimum gratissimum revealed significant inhibitory activity on 9 of the 11 isolates while Commelina erecta and Spilanthes filicaulis revealed similar results on 6 of the 11 clinical isolates.ConclusionThe present findings showed that D. eduli, O. gratissimum,C. erecta and S. filicaulis possess interesting inhibitory properties against S. aureus species. These plants could therefore be good candidates to overcome infectious diseases associated with these microorganisms.

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In vitro Antimicrobial Activity of Agents from Spilanthes filicaulis and Laportea ovalifolia against Some Drug Resistant Bacteria

Abstract: Aims:In a search for natural substances with potential for the treatment of typhoid fevers and urinary tract infections (UTI), extracts and compounds obtained from S. filicaulis and L. ovalifolia were tested for antibacterial activity.

Cited by 6 publications

References 15 publications

Antibacterial and antibiotic-modulation activity of six Cameroonian medicinal plants against Gram-negative multi-drug resistant phenotypes

Antibacterial and antibiotic-modulation activity of six Cameroonian medicinal plants against Gram-negative multi-drug resistant phenotypes

Ethnobotany and the Role of Plant Natural Products in Antibiotic Drug Discovery

Anti-Staphylococcus aureus activity of methanol extracts of 12 plants used in Cameroonian folk medicine

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