In vitro antileishmanial activity of trans-stilbene and terphenyl compounds

Castelli, Germano; Bruno, Federica; Vitale, Fabrizio; Roberti, Marinella; Colomba, Claudia; Giacomini, Elisa; Guidotti, Laura; Tolomeo, Manlio

doi:10.1016/j.exppara.2016.03.007

Cited by 13 publications

(17 citation statements)

References 43 publications

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“…The results showed that the piceatannol signi cantly increased the expression level of annexin-V compared to untreated control [25]. Another study on L. infantum promastigotes was shown that treatment of parasites with 10 µg/ml compound 3 (resveratrol derivate) for 48 h induced PS externalization suggesting that apoptosis activation is the cause of parasites death, while this compound has not shown apoptotic effects on macrophage cells [18]. Ferreira et al (2014) reported a 2.9-fold increase in the percentage of annexin Vpositive L. infantum promastigotes upon resveratrol treatment which suggests leishmanicidal activity of resveratrol [24].…”

Section: Subgroup Analysismentioning

confidence: 96%

“…Resveratrol represents Cis and Trans isomeric forms in nature that biological activity of it associated with Tran's form [17]. Despite several studies about the potential activity of resveratrol against both promastigotes and amastigotes of Leishmania parasites [18,19], associated studies with antileishmanial activity of resveratrol still is in its infancy. Moreover, resveratrol or analogues could also be a novel potential drug in leishmaniasis management and need to be further investigated in future.…”

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confidence: 99%

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Leishmanicidal effects of resveratrol and its derivatives: a systematic review and meta-Analysis

Dashatan¹,

Ashrafmansouri²,

Koushki³

et al. 2020

Preprint

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Background Leishmaniasis is one of the most important health problems worldwide. The evidence has suggested that resveratrol and its derivatives have anti-leishmanial effects; however, the results are inconsistent and inconclusive. The aim of this study was to assess the effect of resveratrol and its derivatives on the Leishmania viability through a systematic review and meta-analysis of available relevant studies. Methods The electronic databases PubMed, ScienceDirect, Embase, Web of Science and Scopus were queried between October 2000 and April 2020 using a comprehensive search strategy. The eligible articles selected and data extraction conducted by two reviewers. Mean differences of IC50 (concentration leading to reduction of 50% of Leishmania) for each outcome was calculated using random-effects models. Sensitivity analyses and prespecified subgroup were conducted to evaluate potential heterogeneity and the stability of the pooled results. Publication bias was evaluated using the Egger’s and Begg’s tests. We also followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines for this review. Results Ten studies were included in the meta-analysis. We observed that RSV and its derivatives had significant reducing effects on Leishmania viability in promastigote [24.02 µg/ml; (95% CI 17.1, 30.8); P < 0.05; I2 = 99.8%; P heterogeneity = 0.00] and amastigote [18.3 µg/ml; (95% CI 13.5, 23.2); P < 0.05; I2 = 99.6%; P heterogeneity = 0.00] stages of Leishmania. A significant publication bias was observed in the meta-analysis. Sensitivity analyses showed a similar effect size while reducing the heterogeneity. Subgroup analysis indicated that the pooled effects of leishmanicidal of resveratrol and its derivatives were affected by type of stilbenes and Leishmania species. Conclusions Our findings clearly suggest that the strategies for the treatment of leishmaniasis should be focused on natural products such as RSV and its derivatives. Further study is needed to identify the mechanisms mediating this protective effects of RSV and its derivatives in leishmaniasis.

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Section: Subgroup Analysismentioning

confidence: 96%

mentioning

confidence: 99%

Leishmanicidal effects of resveratrol and its derivatives: a systematic review and meta-Analysis

Dashatan¹,

Ashrafmansouri²,

Koushki³

et al. 2020

Preprint

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“…The following compound, pinosylvin (3,5-dihydroxy-trans-stilbene), is the natural polyphenol, trans-stilbenoid found in heartwoods and leaves of Pinus sylvestris that possess numerous biological properties [72]. It is produced by plants as a secondary metabolite to protect against insects and microbes [79]. Pinosylvin exerts various biological activities, which are shown in Table 1.…”

Section: Pinosylvin-stilbene Of Underestimated Importancementioning

confidence: 99%

More Than Resveratrol: New Insights into Stilbene-Based Compounds

et al. 2020

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The concept of a scaffold concerns many aspects at different steps on the drug development path. In medicinal chemistry, the choice of relevant “drug-likeness” scaffold is a starting point for the design of the structure dedicated to specific molecular targets. For many years, the chemical uniqueness of the stilbene structure has inspired scientists from different fields such as chemistry, biology, pharmacy, and medicine. In this review, we present the outstanding potential of the stilbene-based derivatives. Naturally occurring stilbenes, together with powerful synthetic chemistry possibilities, may offer an excellent approach for discovering new structures and identifying their therapeutic targets. With the development of scientific tools, sophisticated equipment, and a better understanding of the disease pathogenesis at the molecular level, the stilbene scaffold has moved innovation in science. This paper mainly focuses on the stilbene-based compounds beyond resveratrol, which are particularly attractive due to their biological activity. Given the “fresh outlook” about different stilbene-based compounds starting from stilbenoids with particular regard to isorhapontigenin and methoxy- and hydroxyl- analogues, the update about the combretastatins, and the very often overlooked and underestimated benzanilide analogues, we present a new story about this remarkable structure.

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“…Pinosylvin ( trans -3,5-dihydroxystilbene) is a plant secondary metabolite activated by microbes or insects that is biosynthesized through a general phenylalanine metabolic pathway in genus Pinus [ 125 , 126 ]. Although a pharmaceutically promising anti-antioxidant, anti-cancer, cardioprotective, anti-inflammatory, and chemopreventive substance, its original productivity from plants is very low [ 81 , 127 , 128 , 129 ].…”

Section: Application Of Crispr/cas9 Technology To Engineer Bacterimentioning

confidence: 99%

Applications of CRISPR/Cas System to Bacterial Metabolic Engineering

Cho

Shin

Cho

2018

IJMS

121

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The clustered regularly interspaced short palindromic repeats/CRISPR-associated (CRISPR/Cas) adaptive immune system has been extensively used for gene editing, including gene deletion, insertion, and replacement in bacterial and eukaryotic cells owing to its simple, rapid, and efficient activities in unprecedented resolution. Furthermore, the CRISPR interference (CRISPRi) system including deactivated Cas9 (dCas9) with inactivated endonuclease activity has been further investigated for regulation of the target gene transiently or constitutively, avoiding cell death by disruption of genome. This review discusses the applications of CRISPR/Cas for genome editing in various bacterial systems and their applications. In particular, CRISPR technology has been used for the production of metabolites of high industrial significance, including biochemical, biofuel, and pharmaceutical products/precursors in bacteria. Here, we focus on methods to increase the productivity and yield/titer scan by controlling metabolic flux through individual or combinatorial use of CRISPR/Cas and CRISPRi systems with introduction of synthetic pathway in industrially common bacteria including Escherichia coli. Further, we discuss additional useful applications of the CRISPR/Cas system, including its use in functional genomics.

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In vitro antileishmanial activity of trans-stilbene and terphenyl compounds

Cited by 13 publications

References 43 publications

Leishmanicidal effects of resveratrol and its derivatives: a systematic review and meta-Analysis

Leishmanicidal effects of resveratrol and its derivatives: a systematic review and meta-Analysis

More Than Resveratrol: New Insights into Stilbene-Based Compounds

Applications of CRISPR/Cas System to Bacterial Metabolic Engineering

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