In vitro Antifungal Susceptibility Testing of Clinical and Environmental Fusarium Isolates in Iran

Abstract

Background: Members of the genus Fusarium are common soil saprophytes and important plant pathogens which also cause a wide spectrum of diseases ranging from onychomycosis to the life -threatening systemic infections. The antifungal susceptibility patterns of Fusarium isolates varies in different species. Objectives: This study was undertaken to investigate the antifungal susceptibility pattern of environmental and clinical Fusarium isolates to conventionally -used azole antifungal drugs in Iran. Methods: A total of 36 Fusarium isolates (16 clinical and 20 environmental) were included in this study. All environmental isolates were obtained from the culture collection of medical mycology laboratory

Prevalence, genetic diversity and antifungal susceptibility profiles of F. fujikuroi, F. solani and Fusarium incarnatum‐equiseti species complexes from onychomycosis in north of Iran

“…Based on the obtained results, although F. proliferatum was sensitive to two new imidazole and amphotericin B, all F. proliferatum samples were resistant to other antifungal agents. Eventually, the obtained results approved the reports of other researches on low activity of itraconazole and voriconazole against F. proliferatum 17,28,43 …”

“…Eventually, the obtained results approved the reports of other researches on low activity of itraconazole and voriconazole against F. proliferatum. 17,28,43…”

Fusarium keratitis in a Brazilian tropical semi‐arid area: Clinical–epidemiological features, molecular identification and antifungal susceptibility

“…1,26,37 Available data on fungal keratitis in Brazil are scarce and have mainly been collected from regions with humid subtropical climate. [14][15][16][17][18][19][20][21][22] Given the vast territorial dimension of Brazil, with diverse biomes, climates, as well as social and populational singularities, understanding the clinical and etiological characteristics of fungal keratitis at a regional level A study conducted by Ibrahim et al, 38 analysing the prescription and sale of topical ocular natamycin and amphotericin over 6 years in Brazil, revealed that the periods with the highest commercialization of these drugs coincided with months of lower relative humidity.…”

“…51 However, previous studies have shown variations in antifungal susceptibility among isolates of Fusarium within the same species complex. 14,19 Although breakpoints have not been described for Fusarium, associated with better outcomes as reepithelialization occurs more rapidly in these cases. 28 According to Oechsler et al, 19 isolates with higher MIC values are more challenging to treat and take longer to respond to therapy.…”

“…In Brazil, almost all studies have been conducted in temperate or subtropical regions, located in the South and Southeast areas of the country, respectively. [14][15][16][17][18][19][20][21][22] The characteristics of FK in Brazilian tropical areas-where high temperatures and large numbers of unprotected farm workers may favour the occurrence of the disease-are unknown. Thus, this research aimed to describe the main clinical and epidemiological characteristics of FK cases occurring in a Brazilian tropical semi-arid area during the period from October 2019 to March 2022.…”