In vitro antifungal susceptibilities of six antifungal drugs against clinical Candida glabrata isolates according to EUCAST

Abstract

Background and Purpose: Candida glabrata is the second cause of candidiasis. The mortality rate of C. glabrata infections is about 40%; accordingly, it may be life threatening, especially in immunocompromised hosts. Regarding this, the current study was conducted to evaluate the regional patterns of the antifungal susceptibility of clinical C. glabrata isolated from the patients referring to the health centers located in Ahvaz, Iran.
 Materials and Methods: In this study, a total of 30 clinical strains of C. glabrata isolates were recovered from different body sites (i.e., vagina, mouth, and urine). Phenotypic characteristics and molecular methods were used to identify the isolates. The minimum inhibitory concentration (MIC) was determined according to the European Committee on Antimicrobial Susceptibility Testing.
 Results: Our findings demonstrated that 20%, 80%, and 6.7% of the isolates were resistant to amphotericin B, terbinafine, and posaconazole, respectively, while all the isolates were found to be fluconazole susceptible dose dependent and susceptible to voriconazole and caspofungin.
 Conclusion: Our study suggested that voriconazole had high potency against C. glabrata isolates. Consequently, this antifungal agent can be an alternative drug in the treatment of resistant patients. These results can be helpful for the successful treatment of patients in different regions.

Facile Green Synthesis of Zinc Oxide Nanoparticles with Potential Synergistic Activity with Common Antifungal Agents against Multidrug-Resistant Candidal Strains

“…Only C. glabrata was resistant to terbinafine antifungal, whereas Candida albicans and Candida tropicalis were found to be terbinafine sensitive. Fatahinia et al (2020) reported that 80% of isolated C. glabrata strains were resistant to terbinafine antifungal drugs [87]. The resistance of candidal to terbinafine has been linked to a single missense mutation in the squalene epoxidase gene, resulting in amino acid substitutions [88].…”

Telomeric and Sub-Telomeric Structure and Implications in Fungal Opportunistic Pathogens

“…C. glabrata has emerged as an important nosocomial fungal pathogen associated with a high mortality rate, around 40%, comparable to the ones associated with C. albicans [ 57 ]. A likely contributor to this is increased resistance to antifungal agents, particularly azoles [ 50 , 54 , 55 , 58 , 59 ]. In addition, the prevalence of implant infections caused by fungal pathogens has dramatically increased over the last 10 years.…”