In vitro antifungal evaluation and structure–activity relationships of a new series of chalcone derivatives and synthetic analogues, with inhibitory properties against polymers of the fungal cell wall

López, Silvia N.; Castelli, María Victoria; Zacchino, Susana; Domínguez, José N.; Lobo, Gricela; Charris-Charris, Jaime; Cortés, Juan Carlos G.; Ribas, Juan Carlos; Devia, Cristina; Rodrı́guez, Ana; Enriz, Ricardo D.

doi:10.1016/s0968-0896(01)00116-x

Cited by 290 publications

(148 citation statements)

References 33 publications

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“…As far as the constituents that are probably responsible for the antifungal effects are concerned, they are comparable with propolis samples originating from other countries reported in the literature [20][21][22][23][24][25][26][27][28][29][30][31][32]. Future research of propolis is needed, particularly in the field of isolation and detailed description of its biologically active compounds.…”

Section: Discussionsupporting

confidence: 62%

“…phenolic acids and their esters, especially hydroxy and methoxy substituted derivates of cinnamic acid (E-3-phenylprop-2-enoic), further benzoic acid, chalcones (E-1,3-diphenylprop-2-en-1-ones) may participate in the antifungal properties of propolis [20,[28][29][30][31]. The mechanism of antifungal action of flavonoids and other α, β-unsaturated oxocompounds probably results from the reaction of the vinylenic double bond with sulfanyl groups in enzymes, which finally interferes with the synthesis of fungal cell wall [32].…”

Section: Discussionmentioning

confidence: 99%

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In vitro antifungal activity of propolis samples of Czech and Slovak origin

Buchta¹,

Černý

Opletalová

2011

Open Life Sciences

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Propolis has been used in traditional folk medicine for ages owing to a number of biological effects. Four propolis samples of Czech and one of Slovak origin were extracted using Soxhlet apparatus and analysed by thin-layer chromatography. Raw propolis samples and their extracts were tested by microdilution broth method to determine minimal inhibitory concentration (MIC) in eight strains of human pathogenic fungi. Raw propolis samples showed a lower in vitro antifungal activity than their extracts. In general, the petroleum ether extracts exhibited the highest in vitro antifungal activity (MIC range of 16-64 µg/ml). The content of flavonoids in the samples varied according to region. The highest amount of flavonoids was found in sample A that originated from Broumov (4%). The most susceptible to the propolis extracts were Trichophyton mentagrophytes and Candida albicans. The propolis samples of Czech and Slovak origin and their extracts showed a considerable in vitro antifungal effect which was associated especially with nonpolar petroleum ether and toluene extracts. There was only a partial correlation between flavonoids content and in vitro antifungal activity.

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Section: Discussionsupporting

confidence: 62%

Section: Discussionmentioning

confidence: 99%

In vitro antifungal activity of propolis samples of Czech and Slovak origin

Buchta¹,

Černý

Opletalová

2011

Open Life Sciences

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“…López et al [16] suggested that electron-donating substituents (e.g.,´OCH 3 ) in ring B of chalcones decrease their antifungal activity towards human dermatophytes, while electron acceptor groups (e.g.,´NO 2 ) at the para position have the opposite effect and augment this activity.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Activity of Xanthohumol and Its Selected Structural Analogues

Stompor

Żarowska

2016

Molecules

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Abstract:The objective of this study was to evaluate the antimicrobial activity of structural analogues of xanthohumol 1, a flavonoid compound found in hops (Humulus lupulus). The agar-diffusion method using filter paper disks was applied. Biological tests performed for selected strains of Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) bacteria, fungi (Alternaria sp.), and yeasts (Rhodotorula rubra, Candida albicans) revealed that compounds with at least one hydroxyl group-all of them have it at the C-4 position-demonstrated good activity. Our research showed that the strain S. aureus was more sensitive to chalcones than to the isomers in which the heterocyclic ring C is closed (flavanones). The strain R. rubra was moderately sensitive to only one compound: 4-hydroxy-4'-methoxychalcone 8. Loss of the hydroxyl group in the B-ring of 4'-methoxychalcones or its replacement by a halogen atom (´Cl,´Br), nitro group (´NO 2 ), ethoxy group (´OCH 2 CH 3 ), or aliphatic substituent (´CH 3 ,´CH 2 CH 3 ) resulted in the loss of antimicrobial activity towards both R. rubra yeast and S. aureus bacteria. Xanthohumol 1, naringenin 5, and chalconaringenin 7 inhibited growth of S. aureus, whereas 4-hydroxy-4 1 -methoxychalcone 8 was active towards two strains: S. aureus and R. rubra.

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“…synthesied to study their enhanced biological activity 5,6,7 . The newly synthesized chalcone diols and polyesters are further screened for their anticancer activity.…”

mentioning

confidence: 99%

Untitled

2018

IJPSR

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Breast cancer is one of the most common causes of death in women. Chalcone exhibit chemopreventive and antitumor effects. As a part of proactive approach in the fight against breast cancer, two copolyesters using varying chalcone diols as monomer and varying aliphatic and aromatic acid chlorides were synthesised by solution polycondensation method. The two copolyesters were characterized by solubility and viscosity measurements. The structure of the copolyesters was established by FT-IR, 1 H NMR, 13 C NMR and MALDI. The monomer and copolyesters were studied for their anticancer activity using MCF-7 Cell Line and their cytotoxic effect were studied on VERO Cell Line by MTT assay. The IC 50 values were calculated using the Software Graph Pad Prism Version 7 and ED 50 plus v 1.0. The Selectivity index indicates that the chalcone HHEP and the two copolyesters are good anticancer agents and the chalcone MHEP is cytotoxic. The Selectivity index were found to be more than two, these copolyesters can be targeted individually or in combination with cancer drug in chemotherapy.

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In vitro antifungal evaluation and structure–activity relationships of a new series of chalcone derivatives and synthetic analogues, with inhibitory properties against polymers of the fungal cell wall

Cited by 290 publications

References 33 publications

In vitro antifungal activity of propolis samples of Czech and Slovak origin

In vitro antifungal activity of propolis samples of Czech and Slovak origin

Antimicrobial Activity of Xanthohumol and Its Selected Structural Analogues

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