In vitro antifungal activity of cassia fistula extracts against fluconazole resistant strains of Candida species from HIV patients

Sony, P.; Kalyani, M; Jeyakumari, D; Kannan, Iyanar; Sukumar, R.G.

doi:10.1016/j.mycmed.2017.07.010

Cited by 17 publications

(9 citation statements)

References 16 publications

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“…Similarly, the antifungal activity against fluconazole resistant Candida isolates was reported in Cassia fistula (Sony et al 2018 ). Cassia fistula seed extract reportedly disrupts the cell membrane in C. albicans , resulting in damage to yeast cells (Sitarek et al 2020a , b ).…”

Section: Discussionmentioning

confidence: 77%

In vitro antidermatophytic activity of bioactive compounds from selected medicinal plants

2021

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Fungal infections are among the most difficult diseases to manage in humans. Eukaryotic fungal pathogens share many similarities with their host cells, which impairs the development of antifungal compounds. Therefore, it is desirable to harness the pharmaceutical potential of medicinal plants for antifungal drug discovery. In this study, the antifungal activity of sixteen plant extracts was investigated against selected dermatophytic fungi. Of the sixteen plants, the cladode (leaf) of Asparagus racemosus, and seed extract of Cassia occidentalis showed antifungal activity against Microsporum gypseum, Microsporum nanum, Trichophyton mentagrophytes and Trichophyton terrestre. The plant antifungal compounds were located by direct bioassay against Cladosporium herbarum. IR and NMR spectrometry analyses of these compounds identified the presence of saponin (in A. racemosus) and hydroxy anthraquinone (in C. occidentalis) in these antifungal compounds. The antidermatophytic activity of plant anthraquinone and saponins with reports of little or no hemolytic activity, makes these compounds ideal for alternative antifungal therapy and warrants further in-depth investigation in vivo.

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Section: Discussionmentioning

confidence: 77%

In vitro antidermatophytic activity of bioactive compounds from selected medicinal plants

2021

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“…Therefore, search of anti-Candida molecules from natural sources such as plants has been undertaken. In recent years, different herbal products and molecules exhibiting anti-Candida activities, have been reported [43][44][45]. Candida albicans is responsible of severe invasive infections characterized by high mortality rates achieving more than 65% even with antifungal drugs [46].…”

Section: Antifungal Activitymentioning

confidence: 99%

Phytochemical analysis, antioxidant and anti-Candida albicans activities of Annona cherimola Mill. fruit pulp

Benarba

Mendas

2018

Nor. Afr. J. Food Nutr. Res.

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Aims: The main objectives of the present study were to characterize the phytochemical profile of Annona cherimola Mill, to assess its antioxidant characteristics and its antifungal activity against Candida albicans. Methods and Material: Aqueous decoction, aqueous infusion, aqueous maceration, and methanolic maceration were screened for the presence of phytochemicals and to quantify content of phenolics, tannins, and flavonoids. Furthermore, antioxidant activity was assessed using DPPH and FRAP assays, as well the assessment of antifungal activity for the different extracts. Results: Results showed that phenols, tannins, flavonoids, and saponins were present in the four extracts. The aqueous maceration extract presented the highest total phenolic content (3.687 mg GAE/g of extract). Decoction extract showed the lowest phenolic content 2.504 mg GAE/g. Besides, infusion showed the most important total flavonoids content (2.567mg CE/g). The most relevant total antioxidant activity was found for decoction (lowest IC50 12.61 mg/ml AAE). The aqueous maceration exhibited the less antioxidant activity (IC50= 21.98 mg/ml AAE). The best scavenging activity was observed for decoction (IC50=7.27 mg/mL). All the extracts showed a reducing capacity. Infusion exhibited the best reducing power (EC50 = 11.29 mg/mL), compared to decoction (EC50 = 39.32 mg/mL). Regarding antifungal activity, at 100 and 200 µg/mL, decoction and methanolic maceration resulted in 6 and 9 mm inhibition zone, respectively. In addition, at higher doses (800 and 2000 µg/mL), inhibition zone increased in a dose dependent manner for all the extracts. Conclusions: Annona cherimola Mill. could be an important source of bioactive molecules with antioxidant and antifungal activities. Keywords: Annona cherimola Mill., phytochemical screening, flavonoids, antioxidant, Candida albicans.

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“…However, based on safety evaluations, these drugs cause adverse side effects and there have been many cases of resistance [4][5][6]. One of the efforts made to overcome these detrimental effects is to develop drugs from natural ingredients.…”

Section: Introductionmentioning

confidence: 99%

Development of Feminine Area Cleansers with Anti-fungal Properties Using Apple Rose Leaves as an Active Ingredient

Suwendar

Wachidah

Krisnamurti

et al. 2022

KLS

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Fungal infection has a high prevalence rate in the feminine area. The use of natural anti-fungal, natural feminine cleansers can be a solution to this problem. Apple rose leaves are thought to be an alternative active ingredient to be developed into a natural feminine area cleanser. In this study, in vitro antifungal activity of guava leaves was observed on Candidia albicans and their development into a feminine area cleanser. The results based on the ethanol extract, n-hexane fraction, ethyl acetate fraction and water fraction showed that there were high anti-fungal properties. The highest anti-fungal effect was shown by the n-hexane fraction. A feminine area cleanser was developed with the n-hexane fraction of apple rose leaves as the active ingredient. Pharmaceutic evaluation showed that the formulation obtained was milky white, odorless, homogeneous, produced foam with a height of 0.5 cm and had a pH of 4.5. Based on the results of the study, it can be concluded that apple rose leaves have the potential to be developed into a feminine area cleanser. Keywords: apple rose leaves, leukorrhea, natural anti-leukorrhea, feminine area cleansing preparation

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In vitro antifungal activity of cassia fistula extracts against fluconazole resistant strains of Candida species from HIV patients

Cited by 17 publications

References 16 publications

In vitro antidermatophytic activity of bioactive compounds from selected medicinal plants

In vitro antidermatophytic activity of bioactive compounds from selected medicinal plants

Phytochemical analysis, antioxidant and anti-Candida albicans activities of Annona cherimola Mill. fruit pulp

Development of Feminine Area Cleansers with Anti-fungal Properties Using Apple Rose Leaves as an Active Ingredient

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