In vitro antifungal activity of curcumin mediated by photodynamic therapy on Sporothrix brasiliensis

Legabão, Bárbara Cipulo; Galinari, Camila Barros; Santos, Rafaela Said dos; Bruschi, Marcos Luciano; Gremião, Isabella Dib Ferreira; Boechat, Jéssica Sepúlveda; Pereira, Sandro Antônio; Malacarne, L. C.; Caetano, Wilker; Mendonca, Patricia; Svidzinski, T. I. E.

doi:10.1016/j.pdpdt.2023.103659

Cited by 3 publications

(2 citation statements)

References 21 publications

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Section: Natural Productsmentioning

confidence: 99%

“…The pharmacokinetic, pharmacodynamic, and clinical features of curcumin have been identified and described in numerous research studies [133]. Numerous studies have shown that curcumin's wide range of pharmacological properties includes antifungal [134], anti-inflammatory [135,136], anti-bacterial [137,138], anti-viral [139,140], and anticancer [141] Curcumin possesses potent antifungal properties against pathogenic fungal strains of C. albicans, Cryptococcus neoformans, Aspergillus spp., and Paracoccidioides brasiliensis [139,140,142,143]. However, issues such as poor acid tolerance and water solubility, low bioavailability, and enzymatic degradation have prevented its development into a clinically effective antimicrobial agent [144].…”

Section: Curcuminmentioning

confidence: 99%

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Antifungal Activities of Natural Products and Their Hybrid Molecules

Khwaza,

Aderibigbe

2023

Pharmaceutics

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The increasing cases of drug resistance and high toxicity associated with the currently used antifungal agents are a worldwide public health concern. There is an urgent need to develop new antifungal drugs with unique target mechanisms. Plant-based compounds, such as carvacrol, eugenol, coumarin, cinnamaldehyde, curcumin, thymol, etc., have been explored for the development of promising antifungal agents due to their diverse biological activities, lack of toxicity, and availability. However, researchers around the world are unable to fully utilize the potential of natural products due to limitations, such as their poor bioavailability and aqueous solubility. The development of hybrid molecules containing natural products is a promising synthetic approach to overcome these limitations and control microbes’ capability to develop resistance. Based on the potential advantages of hybrid compounds containing natural products to improve antifungal activity, there have been different reported synthesized hybrid compounds. This paper reviews different literature to report the potential antifungal activities of hybrid compounds containing natural products.

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Section: Natural Productsmentioning

confidence: 99%

Section: Curcuminmentioning

confidence: 99%

Antifungal Activities of Natural Products and Their Hybrid Molecules

Khwaza,

Aderibigbe

2023

Pharmaceutics

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Photodynamic inactivation by hypericin-P123 on azole-resistant isolates of the Trichophyton rubrum complex as planktonic cells and biofilm

Fernandes,

Conrado,

Perina

et al. 2023

Photodiagnosis and Photodynamic Therapy

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Antifungal activity of indolicidin-derived peptide In-58 against Sporothrix globosa in vitro and in vivo

Li,

Tang,

Liu

et al. 2024

Front. Med.

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In-58, a peptide derived from indolicidin, shows extraordinary antibacterial activity and lower toxicity than indolicidin toward mammalian cells. Here, we investigated the antifungal activity of In-58 against the human pathogen Sporothrix globosa in vitro and in vivo. In-58 markedly inhibited the growth of Sporothrix globosa isolates in microdilution assays and showed no antagonism with any tested antifungal agent (itraconazole, terbinafine or amphotericin B). Scanning electron microscopy and propidium iodide staining indicated that In-58 alters the cell wall integrity and interacts with DNA, leading to disruption of S. globosa in a dose-dependent manner. In S. globosa, the mitochondrial membrane potential decreased and reactive oxygen species increased after treatment with In-58. In vivo experiments in the Galleria mellonella (greater wax moth) larval infection model revealed the effectiveness of In-58 against S. globosa infection with low toxicity. Our results indicate that In-58 possesses remarkable antifungal activity against S. globosa in vitro and in vivo. It has potential as a novel drug for the treatment of sporotrichosis.

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In vitro antifungal activity of curcumin mediated by photodynamic therapy on Sporothrix brasiliensis

Cited by 3 publications

References 21 publications

Antifungal Activities of Natural Products and Their Hybrid Molecules

Antifungal Activities of Natural Products and Their Hybrid Molecules

Photodynamic inactivation by hypericin-P123 on azole-resistant isolates of the Trichophyton rubrum complex as planktonic cells and biofilm

Antifungal activity of indolicidin-derived peptide In-58 against Sporothrix globosa in vitro and in vivo

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