In vitro antidiabetic, antioxidant activities and GC–MS analysis of Rhynchostylis Retusa and Euphorbia Neriifolia leaf extracts

Kumar, Abinash; Mahanty, Biswanath; Goswami, Rajiv Chandra Dev; Barooah, Prajjalendra; Choudhury, Bula

doi:10.1007/s13205-021-02869-7

Cited by 11 publications

(6 citation statements)

References 48 publications

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“…Different extracts of E. neriifolia, such as ethanolic and methanolic extract, were found to be effective in the control of blood glucose levels in the experimental model rat. Different parameters, such as suppressed serum lipid levels; suppressed oral glucose tolerance; inhibition of pro-inflammatory chemicals (iNOS and COX-2); expression of chemokines (CCL8 and CCL4); transformation of T-lymphocytes to T-helper cells; expression of cytokines such as TNF-α, IL-6, 8, and INF-γ; stimulation of signaling molecules (ERK, p38, JNK, NF-kB); activation of immune cells; and suppressed levels of fasting blood glucose were found to be observed in response to E. neriifolia extracts [102][103][104].…”

Section: Anti-diabetic Potentialmentioning

confidence: 94%

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Euphorbia neriifolia (Indian Spurge Tree): A Plant of Multiple Biological and Pharmacological Activities

et al. 2023

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Although India has a well-established and growing economy surrounding synthetic drug chemistry with an antibiotic base, a large part of the population, especially in forested villages and tribal belts, is relying solely on plant-derived drugs. This is due to a lower number of side effects, low chances of resistance development against pathogenic microorganisms, as well as the diversity and affordability of such drugs. In the Indian subcontinents, Euphorbia neriifolia Linn. (EN) is one of the valuable plants from the big family of Euphorbiaceae, which is usually found in rocky and hilly areas. E. neriifolia was found to be useful in curing tumors, abdominal swelling, bronchial infection, hydrophobia, earache, cough and cold, asthma, leprosy, gonorrhea, spleen enlargement, leucoderma, snake bites, scorpion stings, and causing appetite improvement, etc. Different in vitro and in vivo experimental studies were performed to determine the antioxidant, anti-diabetic, immunomodulatory, anti-inflammatory, anti-arthritic, wound healing, anti-atherosclerosis, radioprotective, anti-anxiety, anti-convulsant, anti-psychotic, anti-thrombotic, dermal irritation, hemolytic, analgesic, anti-fertility, diuretic, anti-microbial, anti-diarrheal, and anti-carcinogenic activities of the various parts of EN. Several bioactive compounds, such as euphol, nerifoliol, taraxerol, euphonerins A–G, lectin, etc., were isolated from E. neriifolia and need to be investigated further for various biological activities (cardiovascular and neuronal diseases). In the pharmaceutical sector, E. neriifolia was selected for the development of new drugs due to its broad pharmacological activities. Therefore, in the present review, distribution, classification, morphological and microscopical description, phytochemical investigation, pharmacological activities, medicinal uses, harmful effects, and their treatment were evaluated, especially against different lifestyle-related diseases.

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Section: Anti-diabetic Potentialmentioning

confidence: 94%

“…Sustainability 2022, 14, x FOR PEER REVIEW 38 of 70 immune cells; and suppressed levels of fasting blood glucose were found to be observed in response to E. neriifolia extracts. [102][103][104].…”

Section: Anti-diabetic Potentialmentioning

confidence: 99%

Euphorbia neriifolia (Indian Spurge Tree): A Plant of Multiple Biological and Pharmacological Activities

et al. 2023

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“…The results of these researchers indicated that the aboveground part of the plant exhibited higher antioxidant activity due to low MDA and lipofuscin pigment accumulation, higher scavenging activity, and antioxidant capacity (Stajner et al, 2010). In vitro antidiabetic, antioxidant activities, and GC-MS analysis of Rhynchostylis retusa (L.) Blume and Euphorbia neriifolia L. leaf extracts were revealed by Kumar et al (2021). This study revealed significant inhibition of α-amylase activity and retardation in glucose diffusion with E. neriifolia and R. retusa extract in a dose-dependent manner, depending on the extraction solvent.…”

Section: %)mentioning

confidence: 99%

“…This study revealed significant inhibition of α-amylase activity and retardation in glucose diffusion with E. neriifolia and R. retusa extract in a dose-dependent manner, depending on the extraction solvent. In addition, GC-MS analysis of methanolic, aqueous, and petroleum ether extracts suggested the presence of diverse phytochemical entities with known anti-inflammatory, and antioxidant properties, possibly implicated for use in diabetic conditions (Kumar et al, 2021).…”

Section: %)mentioning

confidence: 99%

Biomarkers of Oxidative Stress in the Equine Erythrocytes after in vitro Treatment with Extracts Derived from Leaves and Pseudobulbs of Coelogyne pandurata Lindl. (Orchidaceae) Plants

Buyun

2023

Agrobiodivers Improv Nutr health life Qual

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The current study was conducted to investigate the antioxidant properties of extracts derived from leaves and pseudobulbs of Coelogyne pandurata Lindl. using biomarkers of oxidative stress (2-thiobarbituric acid reactive substances (TBARS) as biomarkers of lipid peroxidation, aldehydic and ketonic derivatives of oxidative modification of proteins (OMP), total antioxidant capacity TAC)) in the equine erythrocytes after in vitro treatment with the extracts. The obtained results demonstrated the prooxidative activity of C. pandurata extract used in the studied dose (5 mg.mL -1 ) on the equine erythrocytes. Our results also showed that extract derived from the leaves and pseudobulbs of C. pandurata after incubation with erythrocyte samples caused to remaining the TAC level at a high level as compared to the group treated by phosphate buffer (controls), while levels of aldehydic and ketonic derivatives of OMP were unchanged. Our results also revealed that extracts derived from the leaves and pseudobulbs of C. pandurata after incubation with equine erythrocyte samples caused to increase in the TBARS level compared to untreated samples. Future studies will be conducted to evaluate dose-dependent changes in the levels of oxidative stress biomarkers after incubation with extracts derived from C. pandurata using various cell models. Moreover, the plant compound profile characteristics and antioxidant activity of different Coelogyne plants may encourage the wider use of these orchids in the development of new medicinal substances in medicine and veterinary.

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“…(Euphorbiaceae): This plant is found in pantropic and sub-tropic areas worldwide, and was used as a traditional medicine in the treatment of diabetes long time ago. Different extracts and many compounds have been isolated from this plant, but the remarkable antidiabetic action was mostly attributed to polyphenolic compounds that were reported to have an inhibitory action against a-amylase and a-glucosidase activities [117][118][119][120][121] Many carboxylic acids were identi ed in this plant, including 5-O-caffeoyl quinic acid, 3,4-di-o-galloyl quinic acid, syringic, gallic, ellagic, and shikimic acids [18,122,123].…”

Section: Fatty Acids Interact With Fabps By Their Carboxylic Groupsmentioning

confidence: 99%

Naturally-occurring carboxylic acids from traditional antidiabetic plants as potential pancreatic islet FABP3 inhibitors. A molecular docking–aided study

Hyder

2023

Chemico-Biological Interactions

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In vitro antidiabetic, antioxidant activities and GC–MS analysis of Rhynchostylis Retusa and Euphorbia Neriifolia leaf extracts

Cited by 11 publications

References 48 publications

Euphorbia neriifolia (Indian Spurge Tree): A Plant of Multiple Biological and Pharmacological Activities

Euphorbia neriifolia (Indian Spurge Tree): A Plant of Multiple Biological and Pharmacological Activities

Biomarkers of Oxidative Stress in the Equine Erythrocytes after in vitro Treatment with Extracts Derived from Leaves and Pseudobulbs of Coelogyne pandurata Lindl. (Orchidaceae) Plants

Naturally-occurring carboxylic acids from traditional antidiabetic plants as potential pancreatic islet FABP3 inhibitors. A molecular docking–aided study

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