In Vitro Antidiabetic Activities of Extract and Isolated Flavonoid Compounds from &lt;i&gt;Artocarpus altilis&lt;/i&gt; (Parkinson) Fosberg

Lotulung, Puspa Dewi; Mozef, Tjandrawati; Risdian, Chandra; Darmawan, Ahmad

doi:10.22146/ijc.21261

Cited by 9 publications

(6 citation statements)

References 11 publications

(14 reference statements)

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“…Meanwhile, the positive control, acarbose showed a strongest inhibitory activity with IC50 of 6.79 ppm (Rante et al, 2019). In another study, the α-glucosidase enzyme inhibition assay of A. altilis leaf extract showed that ethanol extract and ethyl acetate fraction have antidiabetic activity stronger than quercetin as positive control with IC50 values of 6.79 μg/mL, 5.98 μg/mL and 11.60 μg/mL, respectively (Lotulung et al, 2014).…”

Section: Artocarpus Altilismentioning

confidence: 98%

Antidiabetic potential of medicinal plants from the Peruvian Amazon: A review

Vargas-Arana¹,

Salgado²,

Simirgiotis³

2023

BLACPMA

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Diabetes mellitus is a metabolic disorder characterized by the presence of chronic hyper-glycemia that is accompanied, to a greater or lesser extent, by alterations in the metabolism of carbohydrates, proteins and lipids. It is the leading cause of death in developed countries. Current antidiabetic drug treatments present several adverse effects for which it has started searching for new oral hypoglycemic agents from vegetal species. This review presents the medicinal plants from the Peruvian Amazon used in the treatment of diabetes and a systematic review of their hypoglycemic properties reported in the literature in the last twenty years used in different bibliographic databases. Seventy seven medicinal plants are reported as being used for the treatment of diabetes by Amazonian indigenous people, which 46.75% of species report hypoglycemic activity, evidencing that traditional knowledge is a great source for to searching antidiabetic drugs and also an alternative for future research.

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Section: Artocarpus Altilismentioning

confidence: 98%

Antidiabetic potential of medicinal plants from the Peruvian Amazon: A review

Vargas-Arana¹,

Salgado²,

Simirgiotis³

2023

BLACPMA

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“…Flavonoids extracted from Artocarpus altilis also exhibit inhibition activity against α-glucosidase, with the inhibition type being a non-competitive one [71]. Another source of flavonoids, such as Samama plant extract, has been demonstrated to inhibit α-glucosidase activity [72].…”

Section: Interaction Of Flavonoids With Digestive Enzymesmentioning

confidence: 99%

Flavonoids as Antidiabetic Agents

Cahyana

Adiyanti

2021

Indones. J. Chem.

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Flavonoids are polyphenol compounds that exert many potential health benefits, including diabetes type-II, which is the third most common disease that causes death, right after cancer and cardiovascular diseases. The excessively high level of blood glucose has been believed to trigger type II diabetes. The aim of this review is to describe the flavonoid's ability as an alternative treatment for diabetes type-II patients. This paper addresses several aspects in which flavonoids may impart a pivotal role in starch digestion, such as the interaction of flavonoids with enzymes involved in starch hydrolysis, the role of flavonoids in inhibiting glucose absorption, as well as the interaction of flavonoids with starch to form a complex resistant to hydrolysis. Further studies, however, are suggested to extensively carry out, particularly the ones dealing with the intervention study using human volunteers to reveal the role of flavonoids in the real applications. The data on human intervention studies are still rare and can further be exploited using meta-analysis to have firmer results. Flavonoids in the food matrix are more realistic to perform to reveal the effect of interaction with other compounds, which may affect the mechanism of flavonoids interaction or their bioavailability.

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“…Artikel ini menyajikan perkembangan terkini yang lebih komprehensif dari tahun 2000 hingga 2020 meliputi aspek etnobotani di Indonesia, studi fitokimia, farmakologi, dan toksikologi. Aspek aktivitas farmakologi yang dikaji seperti aktivitas antidiabetes, antioksidan, pelindung radiasi UV, antiatherosklerosis, antihipertensi, antibakteri, antijamur, antiinflamasi, antikanker, kardioprotektif, antimalaria, serta mampu memperbaiki fungsi ginjal (Adaramoye & Akanni, 2014;Andriani, 2013;Hafid dkk., 2016;Haryoto & Widowati, 2018;Lan et al, 2013;Lotulung et al, 2014;Riasari dkk., 2017;Siddesha et al, 2011;Tiraravesit et al, 2015).…”

Section: Pendahuluanunclassified

“…Senyawa AC-31 merupakan senyawa antidiabetes yang paling poten dibandingkan dengan AC-51, AC-33 dan siklokommunol dengan nilai IC50 masing-masing sebesar 15,73; 24,41; 49,49; dan 72,20 μg/mL. Senyawa AC-31 menghambat enzim α-glukosidase secara tidak kompetitif dalam studi kinetik metode Lineweaver-Burk (Lotulung et al, 2014).…”

Section: A Antidiabetesunclassified

KAJIAN ETNOBOTANI, FITOKIMIA, FARMAKOLOGI DAN TOKSIKOLOGI SUKUN (Artocarpus altilis (Park.) Fosberg)

Yumni¹,

Widyarini²,

Fakhrudin

2021

J. Tumbuhan Obat Indonesia

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ABSTRACT Indonesia is a country with large plant biodiversity with medicinal properties, such as “sukun” (Artocarpus altilis) or known as “breadfruit”. Breadfruit is a woody evergreen plant that has been used traditionally for various purposes, including medication. The fruit is rich in carbohydrates and fibers as a food source. The leaf and cortex are the most widely used for treating various diseases and other health benefits. This article aimed to present a comprehensive review on the potency of breadfruit from the perspective of ethnobotany, phytochemistry, pharmacology, and toxicology. The data in this narrative review was obtained from the scientific journals in the databases of Google Scholar, PubMed, Scopus, and ScienceDirect. Other credible sources, such as textbooks, student thesis, and patents were also used to support the main data. Based on the literature study, breadfruit has been used empirically in Indonesia as a medicinal herb. The scientific data of breadfruit showed antiinflammatory, antiplatelet, antioxidant, antiatherosclerosis, antihyperlipidemic, antimalaria, antidiabetic, cardioprotective, and anticancer activities. Breadfruit contains terpenoids, flavonoids, alkaloids, and phenolics as bioactive compounds. However, the unique compounds are geranylated and prenylated flavonoids such as cycloartenol, artonin V, and cyclomulberin. These compounds are distributed in the leaf, cortex, wood, and fruit. Limited data is available regarding the toxicology profile of breadfruit. Breadfruit leaves ethanol extract did not show any significant toxic effects in the animal experiments. However, the toxicity of the water extract is unclear, and thus, needs to be investigated to ensure its safety. Keywords: Artocarpus communis, bioactivity, chemical constituents, ethnopharmacology ABSTRAK Indonesia dikenal sebagai negara yang kaya akan keragaman tumbuhan berpotensi obat, diantaranya sukun (Artocarpus altilis). Sukun merupakan tanaman berkayu yang secara tradisional dimanfaatkan untuk berbagai keperluan termasuk pengobatan. Buah sukun mengandung karbohidrat dan serat sebagai sumber pangan. Daun dan batang sukun merupakan bagian yang paling banyak dimanfaatkan dalam pengobatan dan kesehatan. Reviu artikel ini bertujuan untuk mengkaji secara komprehensif potensi sukun dari sudut pandang etnobotani, fitokimia, farmakologi, dan toksikologi. Artikel narrative review ini ditulis berdasarkan data yang diperoleh dari kajian literatur hasil penelitian yang ada di basis data Google Scholar, PubMed, Scopus, dan ScienceDirect. Beberapa sumber pustaka lain seperti buku, naskah tugas akhir dan paten juga digunakan untuk memperkaya penulisan. Hasil kajian literatur sukun menunjukkan bahwa tanaman ini memiliki riwayat empiris digunakan sebagai obat tradisional di Indonesia. Hasil penelitian ilmiah menunjukkan sukun memiliki aktivitas antiinflamasi, antiplatelet, antioksidan, antiatherosklerosis, antihiperlipi-demia, antimalaria, antidiabetes, kardioprotektif, dan antikanker. Sukun mengandung senyawa terpenoid, flavonoid, alkaloid, dan senyawa fenolik. Senyawa khas dari tumbuhan genus Artocarpus ini adalah flavonoid dengan gugus geranil atau prenil, misalnya sikloartenol, artonin V, dan siklomulberin. Senyawa tersebut tersebar dalam daun, kulit kayu, batang, dan buah. Data terkait profil toksikologi sukun masih terbatas. Ekstrak etanol daun sukun tidak menunjukkan efek toksik pada hewan uji. Namun, ekstrak airnya belum memiliki profil toksikologi yang jelas sehingga perlu dilakukan pengujian untuk memastikan keamanannya. Kata kunci: Artocarpus communis, bioaktivitas, kandungan kimia, etnofarmakologi

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In Vitro Antidiabetic Activities of Extract and Isolated Flavonoid Compounds from <i>Artocarpus altilis</i> (Parkinson) Fosberg

Cited by 9 publications

References 11 publications

Antidiabetic potential of medicinal plants from the Peruvian Amazon: A review

Antidiabetic potential of medicinal plants from the Peruvian Amazon: A review

Flavonoids as Antidiabetic Agents

KAJIAN ETNOBOTANI, FITOKIMIA, FARMAKOLOGI DAN TOKSIKOLOGI SUKUN (Artocarpus altilis (Park.) Fosberg)

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