In vitro anticancer properties of anthocyanins: A systematic review

Nascimento, Erika de Arruda; Coutinho, Leandro de Lima; Silva, Cleber José da; Lima, Vera Lúcia de Menezes; Aguiar, Jaciana dos Santos

doi:10.1016/j.bbcan.2022.188748

Cited by 22 publications

(14 citation statements)

References 72 publications

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“…Therefore, anthocyanins in mature purple corn have rich nutritional and disease prevention value ( Kang et al., 2012 ; Petroni et al., 2014 ; Gálvez Ranilla, 2020 ; Lee et al., 2020 ). Such as protecting cells ( Hong et al., 2013 ; Poorahong et al., 2021 ), preventing cancer ( Shi et al., 2021 ; Bars-Cortina et al., 2022 ; de Arruda Nascimento et al., 2022 ; Mottaghipisheh et al., 2022 ), preventing cardiovascular diseases ( Wongsa, 2020 ; Dong et al., 2022 ; Miladiyah and Nuryadi, 2022 ) and improving eyesight ( Ghosh and Konishi, 2007 ; Tandon, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Anthocyanins in metabolites of purple corn

2023

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Purple corn (Zea mays L.) is a special variety of corn, rich in a large amount of anthocyanins and other functional phytochemicals, and has always ranked high in the economic benefits of the corn industry. However, most studies on the stability of agronomic traits and the interaction between genotype and environment in cereal crops focus on yield. In order to further study the accumulation and stability of special anthocyanins in the growth process of purple corn, this review starts with the elucidation of anthocyanins in purple corn, the biosynthesis process and the gene regulation mechanism behind them, points out the influence of anthocyanin metabolism on anthocyanin metabolism, and introduces the influence of environmental factors on anthocyanin accumulation in detail, so as to promote the multi-field production of purple corn, encourage the development of color corn industry and provide new opportunities for corn breeders and growers.

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Section: Introductionmentioning

confidence: 99%

Anthocyanins in metabolites of purple corn

2023

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“…Flavonoids and their metabolites can improve human health by acting as phytochemicals [241], nonessential molecules consumed through food or dietary complements, that modulate signaling pathways and decrease inflammation, immune response and oxidative stress processes [43]. This review will treat this topic highlighting flavonoids' role as inter-kingdom signaling molecules also in the context of human pathologies: other works have dedicated valuable efforts to elucidate the medical and nutraceutical potential of these compounds [41,[242][243][244][245][246].…”

Section: Flavonoids As Nutraceuticals and Prebiotics For Human Healthmentioning

confidence: 99%

Flavonoids Are Intra- and Inter-Kingdom Modulator Signals

et al. 2022

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Flavonoids are a broad class of secondary metabolites with multifaceted functionalities for plant homeostasis and are involved in facing both biotic and abiotic stresses to sustain plant growth and health. Furthermore, they were discovered as mediators of plant networking with the surrounding environment, showing a surprising ability to perform as signaling compounds for a multitrophic inter-kingdom level of communication that influences the plant host at the phytobiome scale. Flavonoids orchestrate plant-neighboring plant allelopathic interactions, recruit beneficial bacteria and mycorrhizal fungi, counteract pathogen outbreak, influence soil microbiome and affect plant physiology to improve its resilience to fluctuating environmental conditions. This review focuses on the diversified spectrum of flavonoid functions in plants under a variety of stresses in the modulation of plant morphogenesis in response to environmental clues, as well as their role as inter-kingdom signaling molecules with micro- and macroorganisms. Regarding the latter, the review addresses flavonoids as key phytochemicals in the human diet, considering their abundance in fruits and edible plants. Recent evidence highlights their role as nutraceuticals, probiotics and as promising new drugs for the treatment of several pathologies.

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“…Anthocyanins demonstrated encouraging anticancer effects by targeting oxidative stress (NF-kB/Nrf2), inflammation (PI3K/Akt/mTOR), and apoptotic signaling pathways (Bax/Bcl-2/caspases) [ 39 ]. A limited number of studies highlighted the anticancer properties of anthocyanins but did not pay attention to the novel delivery systems [ 40 ].…”

Section: Plant Colored Secondary Metabolites Of Interest For Oncology...mentioning

confidence: 99%

Intracellular Pathways and Mechanisms of Colored Secondary Metabolites in Cancer Therapy

Sevastre

Manea

Popescu

et al. 2022

IJMS

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Despite the great advancements made in cancer treatment, there are still many unsatisfied aspects, such as the wide palette of side effects and the drug resistance. There is an obvious increasing scientific attention towards nature and what it can offer the human race. Natural products can be used to treat many diseases, of which some plant products are currently used to treat cancer. Plants produce secondary metabolites for their signaling mechanisms and natural defense. A variety of plant-derived products have shown promising anticancer properties in vitro and in vivo. Rather than recreating the natural production environment, ongoing studies are currently setting various strategies to significantly manipulate the quantity of anticancer molecules in plants. This review focuses on the recently studied secondary metabolite agents that have shown promising anticancer activity, outlining their potential mechanisms of action and pathways.

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In vitro anticancer properties of anthocyanins: A systematic review

Cited by 22 publications

References 72 publications

Anthocyanins in metabolites of purple corn

Anthocyanins in metabolites of purple corn

Flavonoids Are Intra- and Inter-Kingdom Modulator Signals

Intracellular Pathways and Mechanisms of Colored Secondary Metabolites in Cancer Therapy

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