In vitro antibacterial effect of carbamide peroxide on oral biofilm

Abstract

This study compared the effects of carbamide peroxide (CP) and chlorhexidine (CHX) on oral biofilm in vitro. Collagen-coated hydroxyapatite discs were inoculated with subgingival plaque. After 3 weeks, the emergent biofilms were subjected to 1-, 3-, and 10-min exposures of a 1% CHX gel, a 5% CP gel and rinse, and a 10% CP gel and rinse. Subsequently, the biofilms were stained using a two-colour fluorescent dye kit for confocal laser scanning microscopy, and the volume ratio of dead bacteria to all bacteria was analysed. Compared to a non-treated gel control, the active agents killed bacteria on all the discs, with higher concentration and longer exposure times killing more bacteria. The rinse form disrupted the biofilm quicker than the gel form. Overall, 10% CP showed more disruption of biofilm and a greater proportion of killed bacteria than 1% CHX (p<0.05).

On the Possibility of Urea Peroxide Formation in ɤ- Irradiated Urea Aqueous Solution : A Spectroscopic Study

“…This similarity was attributed to the weak interaction between urea and hydrogen peroxide. UHP, as an oxidizing agent, has been found to be extremely useful in several applications such as bleaching [8], sterilization [9], and the removal of metal impurities from silicon-containing substrates (e.g. solar cell substrates) [10].…”